Navigation Links
New target discovered for food allergy treatment
Date:11/1/2012

Researchers at National Jewish Health have discovered a novel target for the treatment of food allergies. Erwin Gelfand, MD, and his colleagues report in the October 2012 issue of the Journal of Allergy and Clinical Immunology that levels of the enzyme Pim 1 kinase rise in the small intestines of peanut-allergic mice. Inhibiting activity of Pim 1 markedly reduced the allergic response to peanuts.

"Pim 1, and its associated transcription factor, Runx3, play a crucial role in allergic reactions to peanuts," said Dr. Gelfand, senior author and chair of pediatrics at National Jewish Health. "As such, they offer promising new targets for the treatment of allergic reactions to peanuts, and possibly other foods." Pim1 kinase is involved in many signaling pathways and is expressed in T cells and eosinophils, cell types linked to allergic diseases. Runx3 is a transcription factor associated with the regulation of T cells.

In a mouse model of food allergy, the researchers found that Pim1 kinase levels increased in the intestines of allergic mice that had been fed peanuts, as did various inflammatory cells and levels of cytokine molecules associated with allergies. Levels of Runx3 mRNA, however, dropped significantly in the allergic mice. When researchers administered a small molecule that inhibits the activity of Pim 1 kinase, mice no longer experienced diarrhea and other symptoms associated with their peanut allergy.

Plasma levels of histamine, a potent cause of allergy symptoms, dropped to almost baseline levels after administration of AR460770, which is produced by Array Biopharma. Inflammatory mast cells, eosinophils, and CD4 and CD8 T cells all increased only slightly in response to peanuts. Levels of several cytokine signaling molecules associated with allergies, IL-4, IL-6 and IL-13, also dropped after treatment with the Pim 1 inhibitor. Runx3 mRNA, rose back to near baseline levels.

"Our data identified for the first time that Pim1 kinase contributes in important ways to the development of peanut-induced allergic responses, " said Dr. Gelfand. "Targeting this novel regulatory axis involving Pim 1 kinase and Runx3 offers new therapeutic opportunities for the control of food-induced allergic reactions."


'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Related medicine news :

1. New study finds a common bond between school bullies and their targets: alcohol abuse
2. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
3. Yeast model offers clues to possible drug targets for Lou Gehrigs disease, study shows
4. Mouse model exposes a new type of T cell to target melanoma
5. Moving targets
6. UGA researchers boost efficacy of drugs by using nanoparticles to target powerhouse of cells
7. Cardiovascular disease community calls for tougher targets to curb global risk
8. Discovery of essential genes for drug-resistant bacteria reveals new, high-value drug targets
9. Large lung cancer study shows potential for more targeted therapies
10. Novel therapeutic targets identified for small cell lung cancer
11. Deadly witch hunts targeted by grassroots womens groups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... Falls Church, VA (PRWEB) , ... January 19, 2017 , ... ... Know to Thrive in 2017, **An FDAnews Webinar**, Jan. 26, 2016 — 1:30 p.m. ... to know about the 21st Century Cures Act in order to thrive this year? ...
(Date:1/19/2017)... Atlanta, Georgia (PRWEB) , ... January 19, 2017 ... ... Reconstructive Surgeons hosts the Atlanta Breast Surgery Symposium, a conference where hundreds of ... latest advancements in breast surgery. Covering topics from cosmetic breast augmentation ...
(Date:1/18/2017)... , ... January 18, 2017 , ... Delaware farmer Rick ... St. Louis, Missouri. , Dickerson, of Laurel, farms about a thousand acres of soybeans, ... yellow squash on contract and pumpkins and other vegetables for the fresh market. He ...
(Date:1/18/2017)... USA; and SHANGHAI, China – , ... ... -- Global public health organization NSF International has certified the ... to NSF/ANSI 53: Drinking Water Treatment Units – Health Effects, ... certification verifies that MicroCeramics’ NanoNose Pitcher Filter System filters the ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... their Vice President of Franchise Development, Paula Turner Pizarro, was recently featured on ... which features the insights of top business leaders from across the globe, provides ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... 18, 2017  Kratom leaves, from a South ... often used to prepare tea-like beverages and commercially ... Americans annually to increase alertness, enhance well-being and ... minor aches and pains. PinneyAssociates, review of the ... assist FDA and DEA in determining the most ...
(Date:1/18/2017)... Colo. , Jan. 18, 2017 Safe ... chain of pharmacies based in Loveland, Colorado ... Prescription Vials (LPVs) in selected Good Day locations.     ... have a cost-effective alternative for secure storage," said ... "For less than the price of a cup of ...
(Date:1/18/2017)... 2017 Invetech, the leading developer of ... therapies , has announced a collaboration agreement with ... starvation" treatments for acute leukemia and other oncology ... Invetech will develop systems to enable the commercial-scale ... technology platform, which uses a novel technology to ...
Breaking Medicine Technology: