Navigation Links
New target discovered for food allergy treatment
Date:11/1/2012

Researchers at National Jewish Health have discovered a novel target for the treatment of food allergies. Erwin Gelfand, MD, and his colleagues report in the October 2012 issue of the Journal of Allergy and Clinical Immunology that levels of the enzyme Pim 1 kinase rise in the small intestines of peanut-allergic mice. Inhibiting activity of Pim 1 markedly reduced the allergic response to peanuts.

"Pim 1, and its associated transcription factor, Runx3, play a crucial role in allergic reactions to peanuts," said Dr. Gelfand, senior author and chair of pediatrics at National Jewish Health. "As such, they offer promising new targets for the treatment of allergic reactions to peanuts, and possibly other foods." Pim1 kinase is involved in many signaling pathways and is expressed in T cells and eosinophils, cell types linked to allergic diseases. Runx3 is a transcription factor associated with the regulation of T cells.

In a mouse model of food allergy, the researchers found that Pim1 kinase levels increased in the intestines of allergic mice that had been fed peanuts, as did various inflammatory cells and levels of cytokine molecules associated with allergies. Levels of Runx3 mRNA, however, dropped significantly in the allergic mice. When researchers administered a small molecule that inhibits the activity of Pim 1 kinase, mice no longer experienced diarrhea and other symptoms associated with their peanut allergy.

Plasma levels of histamine, a potent cause of allergy symptoms, dropped to almost baseline levels after administration of AR460770, which is produced by Array Biopharma. Inflammatory mast cells, eosinophils, and CD4 and CD8 T cells all increased only slightly in response to peanuts. Levels of several cytokine signaling molecules associated with allergies, IL-4, IL-6 and IL-13, also dropped after treatment with the Pim 1 inhibitor. Runx3 mRNA, rose back to near baseline levels.

"Our data identified for the first time that Pim1 kinase
'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New study finds a common bond between school bullies and their targets: alcohol abuse
2. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
3. Yeast model offers clues to possible drug targets for Lou Gehrigs disease, study shows
4. Mouse model exposes a new type of T cell to target melanoma
5. Moving targets
6. UGA researchers boost efficacy of drugs by using nanoparticles to target powerhouse of cells
7. Cardiovascular disease community calls for tougher targets to curb global risk
8. Discovery of essential genes for drug-resistant bacteria reveals new, high-value drug targets
9. Large lung cancer study shows potential for more targeted therapies
10. Novel therapeutic targets identified for small cell lung cancer
11. Deadly witch hunts targeted by grassroots womens groups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Steven Reinberg HealthDay ... A potential vaccine to protect children from the worldwide scourge ... Asian children. While the vaccine only prevented dengue fever ... full series of three shots, it protected more than 88 ... dengue fever can lead to hospitalization, and sometimes death. ...
(Date:7/11/2014)... Ticket Down is a reliable source for cheap ... in Wheatland, CA. In the Sacramento California area there ... Train Amphitheatre can do for music fans. The venue has ... of its existence and can seat 18,500 fans each night. ... metro area) will host the “That’s My Kind of Night” ...
(Date:7/11/2014)... 11, 2014 Europe is one of ... large cultivated-and hence, irrigated land area. The agricultural sector ... accounting for around 30.0% of the total water use. ... in the southern region, but far from negligible in ... accounts for over 60.0% of the water use in ...
(Date:7/11/2014)... have been trying to unravel mechanisms that guide function ... generate all blood cells including our immune system. The ... they can only be found in the bone marrow ... culture dish. Now a group of scientists from Dresden ... Universitt Dresden) was able to generate a mouse model ...
(Date:7/11/2014)... Experience Mayan heritage and enjoy the spirit ... the luxury all-inclusive AAA Five Diamond Grand Velas Riviera ... ecological family tour where guests learn about local flora ... Tour at the Mayan archeological site of Coba. Guests ... the Yucatan and the only pyramid people are still ...
Breaking Medicine News(10 mins):Health News:Dengue Fever Vaccine Shows Some Promise in Trial 2Health News:Dengue Fever Vaccine Shows Some Promise in Trial 3Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 3Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 3Health News:Opening-up the stem cell niche 2Health News:Explore the Aura and Mystery of the Yucatan’s Mayan Culture with New Hotel Package at AAA Five Diamond Grand Velas Riviera Maya 2Health News:Explore the Aura and Mystery of the Yucatan’s Mayan Culture with New Hotel Package at AAA Five Diamond Grand Velas Riviera Maya 3
... (Aug. 25, 2009) The Henry M. Jackson Foundation ... three promising Uniformed Services University of the Health Sciences ... year. The program, established in 1988, is comprised of ... Hemming Fellowship. Each fellow receives a stipend and travel ...
... The University of Nottingham and Health Protection Agency East Midlands ... after being commissioned as part of the government,s response to ... long someone is contagious for and advise on a ,safe ... by Professor Jonathan Nguyen Van Tam of the University of ...
... YORK, August 25, 2009 -- Charleen T. Chu, MD, ... David M. Sabatini, MD, PhD, associate professor, Massachusetts Institute ... in Aging Research. Sponsored by The Ellison Medical ... scientists whose research has great potential in advancing understanding ...
... , , SAN ... of Bone and Joint Surgery demonstrates that use of ... effective than both DuraPrep and povidone-iodine at eliminating overall bacteria ... chlorhexidine gluconate and 70 percent isopropyl alcohol), only seven percent ...
... , , , , ... Judd is speaking up for those struggling with chronic pain -- a ... combined. Judd is lending her voice to the national education program ... instpain.com ) to raise awareness about the urgent need to ...
... SAN RAFAEL, Calif., Aug. 25 TBI/Tissue Banks International, one of ... Services (NWTS), a Puget Sound Blood Center program, have entered into ... surgeons and hospitals that rely on them for transplantable tissue. ... immediately, allows TBI to distribute tissue recovered and processed by NWTS ...
Cached Medicine News:Health News:Henry M. Jackson Foundation names fellowship award winners 2Health News:Nottingham scientists commissioned for urgent swine flu research 2Health News:Ellison Medical Foundation awards more than $1 million to mid-career scientists 2Health News:New Data Show ChloraPrep(R) Significantly More Effective Than DuraPrep(TM) and Povidone-Iodine in Eliminating Bacteria From Skin Prior to Shoulder Surgery 2Health News:New Data Show ChloraPrep(R) Significantly More Effective Than DuraPrep(TM) and Povidone-Iodine in Eliminating Bacteria From Skin Prior to Shoulder Surgery 3Health News:New Data Show ChloraPrep(R) Significantly More Effective Than DuraPrep(TM) and Povidone-Iodine in Eliminating Bacteria From Skin Prior to Shoulder Surgery 4Health News:New Data Show ChloraPrep(R) Significantly More Effective Than DuraPrep(TM) and Povidone-Iodine in Eliminating Bacteria From Skin Prior to Shoulder Surgery 5Health News:Country Legend Naomi Judd Joins 'Partners Against Pain' 2Health News:Country Legend Naomi Judd Joins 'Partners Against Pain' 3Health News:TBI/Tissue Banks International and Northwest Tissue Services Announce Collaborative Distribution Agreement 2
(Date:7/11/2014)... July 11, 2014 According to ... "Endoscopy Devices Market (Endoscopes, Endoscopic Operative Devices, and Visualization ... and Forecast, 2013-2019" the global endoscopy devices market was ... expected to grow at a CAGR of 6.8% from ... USD 36.9 billion in 2019. Browse the ...
(Date:7/11/2014)... 2014 Neurelis, Inc. ("Neurelis") today announced an ... option held by Biotie to purchase Neurelis, clearing the ... (intranasal diazepam) for pediatric and adult epilepsy patients who ... year, Biotie has advanced the development program for NRL-1 ... clinical work required for NDA submission to the FDA.  ...
(Date:7/10/2014)... 2014  Breg, Inc., a premier provider of ... FreeRunner™ knee brace with new innovations to help ... return to active lifestyles.  FreeRunner,s patent-pending design acts ... support when patients need it most, and the ... Patellofemoral issues are the most common cause ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2
... study results also demonstrate the longest duration of consistently ... levels shown by a cervical cancer vaccine, TAMPA, ... GSK ) cervical cancer candidate vaccine,CERVARIX(R) provides significant ... human papillomavirus types for nearly six and a half,years, ...
... SOUTH SAN FRANCISCO, Calif., March 10 ... clinical-stage biopharmaceutical,company focused on the discovery, development ... positive interim data,from the company,s ongoing Phase ... SNS-595, in platinum-resistant ovarian cancer patients., ...
Cached Medicine Technology:GSK Cervical Cancer Candidate Vaccine CERVARIX (R) Demonstrates Long-Term Protection for More Than Six Years 2GSK Cervical Cancer Candidate Vaccine CERVARIX (R) Demonstrates Long-Term Protection for More Than Six Years 3GSK Cervical Cancer Candidate Vaccine CERVARIX (R) Demonstrates Long-Term Protection for More Than Six Years 4GSK Cervical Cancer Candidate Vaccine CERVARIX (R) Demonstrates Long-Term Protection for More Than Six Years 5GSK Cervical Cancer Candidate Vaccine CERVARIX (R) Demonstrates Long-Term Protection for More Than Six Years 6Sunesis Pharmaceuticals Reports Positive Interim Data for SNS-595 Single-Agent Activity in Platinum-Resistant Ovarian Cancer 2Sunesis Pharmaceuticals Reports Positive Interim Data for SNS-595 Single-Agent Activity in Platinum-Resistant Ovarian Cancer 3Sunesis Pharmaceuticals Reports Positive Interim Data for SNS-595 Single-Agent Activity in Platinum-Resistant Ovarian Cancer 4Sunesis Pharmaceuticals Reports Positive Interim Data for SNS-595 Single-Agent Activity in Platinum-Resistant Ovarian Cancer 5
... is an effective angina relief ... poor targets. Because it is ... the CO2 Heart Laser 2 ... timely operative decisions to revascularize ...
Ultrasensitive TSH EIA Thyroid Function 025-BC-1003...
TG (Ab) RIA Thyroid Function 014-HD 27.1 Thyroglobulin...
... The anti-TG test kit is a solid ... format. It is designed for the quantitative ... (TG) in serum or plasma. The microplate ... Calibrators, controls and patient samples are pipetted ...
Medicine Products: