Navigation Links
New target discovered for food allergy treatment
Date:11/1/2012

Researchers at National Jewish Health have discovered a novel target for the treatment of food allergies. Erwin Gelfand, MD, and his colleagues report in the October 2012 issue of the Journal of Allergy and Clinical Immunology that levels of the enzyme Pim 1 kinase rise in the small intestines of peanut-allergic mice. Inhibiting activity of Pim 1 markedly reduced the allergic response to peanuts.

"Pim 1, and its associated transcription factor, Runx3, play a crucial role in allergic reactions to peanuts," said Dr. Gelfand, senior author and chair of pediatrics at National Jewish Health. "As such, they offer promising new targets for the treatment of allergic reactions to peanuts, and possibly other foods." Pim1 kinase is involved in many signaling pathways and is expressed in T cells and eosinophils, cell types linked to allergic diseases. Runx3 is a transcription factor associated with the regulation of T cells.

In a mouse model of food allergy, the researchers found that Pim1 kinase levels increased in the intestines of allergic mice that had been fed peanuts, as did various inflammatory cells and levels of cytokine molecules associated with allergies. Levels of Runx3 mRNA, however, dropped significantly in the allergic mice. When researchers administered a small molecule that inhibits the activity of Pim 1 kinase, mice no longer experienced diarrhea and other symptoms associated with their peanut allergy.

Plasma levels of histamine, a potent cause of allergy symptoms, dropped to almost baseline levels after administration of AR460770, which is produced by Array Biopharma. Inflammatory mast cells, eosinophils, and CD4 and CD8 T cells all increased only slightly in response to peanuts. Levels of several cytokine signaling molecules associated with allergies, IL-4, IL-6 and IL-13, also dropped after treatment with the Pim 1 inhibitor. Runx3 mRNA, rose back to near baseline levels.

"Our data identified for the first time that Pim1 kinase contributes in important ways to the development of peanut-induced allergic responses, " said Dr. Gelfand. "Targeting this novel regulatory axis involving Pim 1 kinase and Runx3 offers new therapeutic opportunities for the control of food-induced allergic reactions."


'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Related medicine news :

1. New study finds a common bond between school bullies and their targets: alcohol abuse
2. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
3. Yeast model offers clues to possible drug targets for Lou Gehrigs disease, study shows
4. Mouse model exposes a new type of T cell to target melanoma
5. Moving targets
6. UGA researchers boost efficacy of drugs by using nanoparticles to target powerhouse of cells
7. Cardiovascular disease community calls for tougher targets to curb global risk
8. Discovery of essential genes for drug-resistant bacteria reveals new, high-value drug targets
9. Large lung cancer study shows potential for more targeted therapies
10. Novel therapeutic targets identified for small cell lung cancer
11. Deadly witch hunts targeted by grassroots womens groups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... ... 10 Best Water is excited to announce a new monthly ... topped the list as a result of their commitment to offering clients creative, customized, ... 5100, a top notch water company that specializes in providing the public with refreshing ...
(Date:2/10/2016)... ... February 10, 2016 , ... United Benefit Advisors (UBA), ... latest addition to its growing list of Partner Firms. S.S. Nesbitt is ... Orlando to Huntsville and in between. , Harnessing the experience and insights of ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... change in their patients. Research shows that the Goal Attainment Scale (GAS) captures ... overcome this challenge and learn more about the Goal Attainment Scale, Education Resources ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... revolutionary, biocompatible columns and accessories. These PEEK-lined stainless steel (PLS) columns combine the ... a solution that ensures the integrity of biological samples while operating at ultra-high ...
(Date:2/10/2016)... DC (PRWEB) , ... February 10, 2016 , ... Anxiety ... level since the start of Medicare Part D a decade ago, according to ... comments from older adults on how they are coping with rapidly rising costs. ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)...  Visage Imaging Inc. ("Visage"), a wholly owned ... that the American College of Radiology (ACR) and ... Visage 7 Enterprise Imaging Platform as the new ... SIMulation (SIM). SIM is the assessment component of ... multi-faceted and fully-integrated online assessment, education and remediation ...
(Date:2/10/2016)... Mast Therapeutics, Inc. (NYSE MKT: ... sickle cell disease and heart failure, today announced the ... at a price to the public of $0.275 per ... Company,s common stock and one warrant to purchase one ... price of $0.42 per share. The warrants are exercisable ...
(Date:2/10/2016)... New York , February 10, 2016 ... Growth, Trends and Forecast 2015 - 2023 ", reveals that ... rather slow growth from 2015 to 2023 owing to patent ... a meager CAGR of 1.30% during the forecast period, the ... to US$38.9 bn in 2023. --> Antibacterial Drugs ...
Breaking Medicine Technology: