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New sugar-test to reduce false-positive cancer diagnoses
Date:3/10/2014

The world's most widespread test for ovarian cancer reports false-positives in 94 of 100 diagnosed cases. Now, chemists at the University of Copenhagen working with clinical researchers at University College London have developed a method able to halve the number of false-positives. When fully developed, the new test will spare a significant number of women from unnecessary worry and further testing. Furthermore, global health care providers stand to save substantial sums just by including a test on a certain sugar molecule in tandem with the currently prevailing diagnostic test.

Ola Blixt is a chemical glycobiology professor at the Department of Chemistry, University of Copenhagen. He and Professor Usha Menon have led the research efforts of the teams at the Gynaecological Cancer Research Centre, University College London and the Copenhagen Center for Glycomics, who have succeeded in developing this new method that tests for ovarian cancer. The method helps distinguish between cancer and otherwise benign conditions and is called glycoprofiling. It has been published in the esteemed Journal of Proteome Research, under the title "Microarray Glycoprofiling of CA125 Improves Differential Diagnosis of Ovarian Cancer".

Vital to clear misdiagnosed women

Ola Blixt hopes that glycoprofiling will be incorporated in prevailing ovarian cancer diagnostics "kits" because there is simply so much distress that follows in the wake of a false diagnosis. "When a woman is informed that she might have cancer, she will always be terrified. She will also require further testing and this can be uncomfortable. Furthermore, there is the risk that she will encounter a considerable wait time before being provided with an accurate answer. I think that it is vital to clear those women who are misdiagnosed with cancer in a quick and safe manner. Our researches suggests that the new method, glycoprofiling, could improve differential diagnosis and sign
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Contact: Jes Andersen
jean@science.ku.dk
45-23-60-11-40
University of Copenhagen
Source:Eurekalert  

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New sugar-test to reduce false-positive cancer diagnoses
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