Navigation Links
New study supports view that Lewy bodies are not the primary cause of cell death in PD
Date:1/9/2012

Amsterdam, NL, January 9, 2011 The pathology of Parkinson's disease is characterized by a loss of dopamine-producing neurons in the pars compacta of the substantia nigra (SN), an area of the brain associated with motor control, along with the development of α-synuclein (αS) protein in the form of Lewy bodies (LB) in the neurons that survive. The spread of LB pathology is thought to progress along with the clinical course of Parkinson's disease, although recent studies suggest that they are not the toxic cause of cell death. A new study published in The Journal of Parkinson's Disease finds no support for a primary pathogenic role of LBs, as neither their distribution nor density was associated with the severity of nigral cell loss.

"We investigated the relationship between nigral dopaminergic cell loss, distribution and density of α-synuclein immunoreactive LBs, and the duration of motor symptoms in 97 patients with Parkinson's disease," explains lead investigator Andrew J. Lees, MD, of Queen Square Brain Bank for Neurological Disorders and the Reta Lila Weston Institute for Neurological Studies, UCL Institute of Neurology, London, UK. "Despite the reasonably close correlation between neuronal density in SN and severity of bradykinesia and rigidity in Parkinson's disease, our results suggest that nigral cell loss is gradual and there is considerable variability, which may explain the clinical heterogeneity."

Researchers confirmed that both neuronal number and density in SN in Parkinson's disease decrease over time. The density of nigral neurons was estimated to decrease by 2% each year after confirmation of the clinical diagnosis of Parkinson's disease, but showed marked heterogeneity across patients. Some patients with longer duration of illness still had a significant number of preserved nigral neurons at the time of death. An average of 15% of surviving nigral neurons contained LBs and the age-adjusted proportion of LB-bearing neurons appeared relatively stable through the disease duration. "This could be explained by a passive 'one-pass' phenomenon where the LBs appear at the beginning of the disease and then decrease at the same rate as nigral neurons are lost, or alternatively that a dynamic 'turnover' occurs with some LBs continuously produced and destroyed at the same rate," explains Dr. Lees.

Nigral neuron density was unrelated to the Braak PD stage of the disease (i.e. distribution of LBs in the brain) or to cortical LB densities. "In our view, the fact that neither the widespread regional distribution of LBs nor increased cortical LB densities were found directly linked with pars compacta nigral cell loss lends support to the view that they are not the primary cause of the pathological process leading to cell death in vulnerable regions in the brain in Parkinson's disease," concludes Dr. Lees.


'/>"/>

Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. PSA Test for Prostate Cancer Doesnt Save Lives: Study
2. Study shows no evidence of a mortality benefit to PSA screening
3. Study Offers Clues to Why Some Dont Benefit From Asthma Drugs
4. Mice Exposed to Smoke Helped by Blood Pressure Drug: Study
5. Global Study Finds Drug Abuse Highest in Richer Nations
6. Diabetes Care Thwarted by Unstable Health Insurance: Study
7. Moderate red wine drinking may help cut womens breast cancer risk, Cedars-Sinai study shows
8. Mental Decline Can Start at 45, Study Finds
9. Study finds statin costs 400 percent higher in US compared to UK
10. Drug Eases Gout Flare-ups in Some Patients: Study
11. Study Reveals Whos More Prone to Be a Mean Drunk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... NJ (PRWEB) , ... May 03, 2016 , ... ... BCBSNJ) today announced that it has been honored as one of the nation’s ... the 2016 InformationWeek Elite 100. Horizon received the recognition for technology achievements that ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... pharmacies, will be represented at the 2016 Asembia Specialty Pharmacy Summit held May ... is the largest U.S. health care conference for the specialty pharmacy industry, with ...
(Date:5/3/2016)... Texas (PRWEB) , ... May 03, 2016 , ... ... today announced that it is launching a new client service center in La ... Houston, Texas, and will provide the full range of Empyrean client services. , ...
(Date:5/3/2016)... ... ... Park Cities Pet Sitter has openings for both full-time and part-time ... 75219, 75220, 75225, 75229, 75230, 75231 and 75235 zip codes. These zip codes ... and Park Cities areas of the Metroplex. Candidates must love animals, have attention ...
(Date:5/3/2016)... ... 2016 , ... For the sixth consecutive year, Crawford Technologies ... companies in the annual Branham300 listing. For 23 years, the Branhan300 has highlighted ... revenue. , “We are honored to be on the Branham300 list once ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... Leading Economies with Fastest Real GDP Annual Percentage Change, ... 8 Ireland 7.8 India 7.3, , Source: IMF and TechSci ... comprises of Brazil , Russia , ... Africa , registered the fastest GDP growth during the first decade of ... , recession in Brazil and Russia ...
(Date:4/29/2016)... COUNTY, Calif. , April 29, 2016 /PRNewswire/ ... industry is projected to shift from systems dependent ... replace all types of modality CRT Medical monitors ... Although there are a host of foreseeable benefits ... serious concern; will existing modalities have to be ...
(Date:4/29/2016)... 29, 2016 Automation is one ... due to the growing demands for productivity in speed, ... automated systems are already adept of a wide range ... and manual labor. Instrumentation continues to evolve, and is ... just a few years ago. Originally used mostly by ...
Breaking Medicine Technology: