Navigation Links
New study suggests why vaccines directed against cancer, HIV don't work
Date:12/13/2007

COLUMBIA, Mo. Researchers from the University of Missouri and Imperial College London have found evidence suggesting why vaccines directed against the virus that causes AIDS and many cancers do not work. This research is being published in the Dec. 14 edition of The Journal of Biological Chemistry.

In research spanning more than a decade, Gary Clark, associate professor of Obstetrics, Gynecology and Womens Health in the MU School of Medicine, and Anne Dell, an investigator at Imperial College London, found that HIV, aggressive cancer cells, H. pylori, and parasitic worms known as schistosomes carry the same carbohydrate sequences as many proteins produced in human sperm.

Its our major Achilles heel, Clark said. Reproduction is required for the survival of our species. Therefore we are hard-wired to protect our sperm and eggs as well as our unborn babies from any type of immune response. Unfortunately, our results suggest that many pathogens and tumor cells also have integrated themselves into this protective system, thus enabling them to resist the human immune response.

During the initial stages of life, the body goes through a process where it self-identifies, determining which cells and proteins belong in the body, so it can detect those that do not. After this time, anything foreign is deemed as dangerous, unless the immune system is specifically told to ignore those cells and proteins. This situation arises primarily during reproduction.

When sperm are made, they specifically label their glycoproteins with Lewis carbohydrate sequences, a specific chain of carbohydrates. When these foreign sperm enter the female body, the females immune system does not recognize them as foreign probably because of these Lewis sequences. Similarly, the unborn baby also could be seen as foreign by the mothers immune system, but she produces other types of glycoproteins that likely block any type of immune response in the womb. These events are required for successful human reproduction.

H. pylori is a bacteria known for causing stomach ulcers. Schistosomes live inside our bodies, resisting many types of immune responses. Aggressive tumor cells also can defeat the immune system; this killed more than half a million people in the United States last year. HIV-infected immune cells cause AIDS. The common thread is that each carries Lewis sequences. Clark said this evidence suggests that vaccines are likely ineffective against these diseases because Lewis sequences shut down the specific immune response that enables vaccines to work.

If aggressive cancers and pathogens are using the same system of universally recognizable markers to trick the immune system into thinking theyre harmless, we need to determine exactly how this interaction works, Dell said. This is where were planning to take this research next. Understanding how these markers work at a basic biological and chemical level could lead to new ways to treat or prevent cancers and these other diseases in the future.

This work is creating an entirely new way of thinking about how we must combat viruses like HIV and aggressive tumor cells, Clark said. We have literally spent billions of dollars developing vaccines for AIDS and cancer. However, the latest high profile HIV and tumor vaccine trials have been spectacularly unsuccessful, perhaps for some very good reasons. We must become more clever if we are ever going to solve the problems of cancer and AIDS.


'/>"/>

Contact: Christian Basi
BasiC@missouri.edu
573-882-4430
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... ... The Global Wellness Summit (GWS), an annual conference for international ... travel, spa and beauty in Europe. The organization asked its partner experts in Europe ... researchers - to forecast where wellness is headed in Europe. Predictions range from European ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... The Orthopaedic ... executive committee members: , David G. Lewallen, MD, began his term as president ... president. Michael L. Parks, MD, is OREF’s new president-elect. Richard F. Kyle, MD, will ...
(Date:5/31/2016)... , ... May 31, 2016 , ... In a recent ... Feiner and broadcast on New Rochelle, NY-based WVOX (1460 AM), leading medical ... what she calls the country’s “modern medical money maelstrom.” , During the interview ...
(Date:5/31/2016)... ... May 31, 2016 , ... To meet a growing demand ... industry, The University of Scranton is adding a Certificate in Health Informatics to ... in rapidly growing field of healthcare information. , Healthcare organizations are under ...
(Date:5/30/2016)... , ... May 30, 2016 , ... ... use inside of FCPX," said Christina Austin - CEO of Pixel Film Studios. ... use within Final Cut Pro X. Choose from abstract transitions to more simple ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... 2016 RnRMarketResearch.com adds "Asthma - ... analysis of Asthma therapy at various stages, therapeutics assessment ... administration (RoA) and molecule type, along with latest updates, ... key players involved in the therapeutic development for Asthma ... Complete report on H1 2016 pipeline review of ...
(Date:5/30/2016)... 2016 According to a ... Market by Type (Stability, Raw Materials, Method Validation, ... (Pharmaceutical Companies, Medical Device Companies) - Global Forecast ... healthy growth during the last decade and is ... between 2016 and 2021 to reach USD 4.13 ...
(Date:5/30/2016)... - DCGI grants limited approval to market Stempeucel® product for ... Stempeucel® becomes 5th off-the-shelf Stem cell product to be approved by ... Disease (also known as Thromboangiitis Obliterans) is a major unmet medical ... - Prevalence of Buerger,s Disease is estimated to be 1,000,000 in ... the European Community & USA ...
Breaking Medicine Technology: