Navigation Links
New study suggests stem cells sabotage their own DNA to produce new tissues
Date:2/15/2010

A new study from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa suggests that stem cells intentionally break their own DNA as a way of regulating tissue development. The study, published in Proceedings of the National Academy of Science (PNAS), could dramatically change how researchers think about tissue development, stem cells and cancer.

Human cells contain 46 strands of DNA that code for all our genes. Certain chemicals and UV light can break these strands into pieces, a process that has traditionally been considered a bad thing, leading to cell death or diseases such as cancer if the damage is not repaired quickly. The new research, led by Dr. Lynn Megeney, shows for the first time that stem cells will intentionally cut and then repair their own DNA as a mechanism of activating genes that promote the development of new tissues.

The project started as an attempt to understand how stem cells give rise to new muscle fibres. In 2002, Dr. Megeney and his team discovered that this process of producing new muscle was somehow connected to another important process called programmed cell death, which the body uses to get rid of unwanted cells. When they blocked or removed a key death-promoting protein called caspase 3, they found that stem cells stopped producing new muscle fibres.

"This discovery was very controversial at the time, but dozens of research groups have now reported that cell death proteins control the maturation process of most stem cell types," says Dr. Megeney. "In the last few years, the big mystery has been how cell death proteins manage this complex process."

Now in the 2010 study Dr. Megeney and his team believe they have solved the mystery. They have discovered that the novel effect of caspase 3 in stem cells is related to its ability to activate another protein that cuts up the cell's DNA (called caspase-activated DNase) and has also traditionally been associated with pr
'/>"/>

Contact: Jennifer Paterson
jpaterson@ohri.ca
613-798-5555 x73325
Ottawa Hospital Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... been shown to be a driving force behind ... develops due to chronic inflammation caused by conditions ... relatively few effective treatment options. Now, scientists at ... for the first time in preclinical studies that ... astrocyte elevated gene-1 (AEG-1) halts the development and ...
(Date:9/23/2014)... Becker's Hospital Review has published the 2014 edition ... Systems With Great Orthopedic Programs." , The hospitals ... orthopedic surgery departments, programs or dedicated centers that ... orthopedic departments include physicians who provide outstanding care ... athletes. , This is the fifth year Becker's ...
(Date:9/23/2014)... The "area under the curve of oxygen desaturation" (AUC ... monitoring blood oxygen levels during procedures using sedation, according ... . , The AUC Desat provides information not ... on the depth, duration, and rate of episodes of ... PhD, of University of Cincinnati and colleagues reports on ...
(Date:9/23/2014)... often assumed about single parents, particularly single parents of ... has found that single parents of children younger than ... singles without children -- and more so than single ... Sexual Behavior Among Single Parents of Young Children in ... Journal of Sex Research prior to appearing in ...
(Date:9/23/2014)... 23, 2014 Kenall Manufacturing, a ... its MedMaster™ M4 product line with a new ... M4 product line – currently available with 2'×2' ... providing more flexibility when designing lighting for the ... M4 Series include:, •Three sizes available to ...
Breaking Medicine News(10 mins):Health News:Study uncovers genetic driver of inflammation, uses it to prevent and treat liver cancer 2Health News:125 Hospitals With Great Orthopedic Programs 2Health News:125 Hospitals With Great Orthopedic Programs 3Health News:125 Hospitals With Great Orthopedic Programs 4Health News:125 Hospitals With Great Orthopedic Programs 5Health News:New measure provides more data on oxygen levels during sedation 2Health News:Kinsey study of single parents' dating, sexual activity contradicts assumptions 2Health News:Kenall Expands MedMaster™ M4 Surgical Suite Product Portfolio with New 1'×4' Option 2Health News:Kenall Expands MedMaster™ M4 Surgical Suite Product Portfolio with New 1'×4' Option 3
... URBANA Could preventing colon cancer be as simple as ... University of Illinois study, scientists showed that human colon cancer ... of bioactive compounds present in one cup of this brew, ... medicinal properties. "The caffeine derivatives in mate tea not ...
... of Nebraska-Lincoln will lead a $25 million project to reduce ... coli strains that pose a major threat to public ... Food and Agriculture announced the grant at UNL on Monday, ... coli , or STEC, which cause more than 265,000 illnesses ...
... -- A Kansas State University professor is turning to nutrition ... human nutrition, is helping men make more informed diet decisions ... risk of prostate cancer. Prostate cancer is one of the ... States. "I,m interested in researching ways to prevent prostate ...
... regions of the genome associated with the timing of menopause. ... reproductive lifespan and will provide insights into conditions connected to ... Menopause is a major hormonal change that affects most ... of menopause can have a huge impact on fertility, as ...
... , FRIDAY, Jan. 20 (HealthDay News) -- The number of ... definition of the disorder is adopted by mental health experts ... of the changes will be, but they agree there will ... and the professionals who treat them. The changes could affect ...
... in younger patients treated for breast cancer is seriously ... infertility, premature menopause, a decrease in physical activity and ... UCLA,s Jonsson Comprehensive Cancer Center. , The study, published ... Institute , found that the mental issues faced by ...
Cached Medicine News:Health News:Compounds in mate tea induce death in colon cancer cells 2Health News:U. of Nebraska to lead $25 million project targeting E. coli threat 2Health News:U. of Nebraska to lead $25 million project targeting E. coli threat 3Health News:Eating smart: Researcher studies foods, dietary supplements that may reduce risk of prostate cancer 2Health News:Genes and timing of menopause 2Health News:Experts Weigh Changes to Definition of Autism 2Health News:Experts Weigh Changes to Definition of Autism 3Health News:Quality of life for younger breast cancer patients more adversely affected than older women 2Health News:Quality of life for younger breast cancer patients more adversely affected than older women 3
(Date:9/23/2014)... , September 23, 2014 ... oncology biopharmaceutical company, today announces it has been ... Drug Discovery Award from the UK,s Wellcome Trust ... its proprietary, novel cancer target. The ... identify and fund especially promising, innovative new therapeutic ...
(Date:9/23/2014)... 23, 2014  As physicians seek information about ... channels to learn about new therapies or ask ... a new report by global sales and marketing ... communicating via a customized mix of digital media ... opportunity to engage with physicians. And, productive engagement ...
(Date:9/23/2014)... 2014   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade hypothermic storage and ... shipping products for cells and tissues  ("BioLife" or ... Scientific Advisory Board.  The new members are Jason ... Dr. Acker is a Senior Development Scientist ...
Breaking Medicine Technology:BerGenBio Granted a Prestigious Wellcome Trust Seeding Drug Discovery Award 2BerGenBio Granted a Prestigious Wellcome Trust Seeding Drug Discovery Award 3As sales reps see doors close for in-person visits with physicians, digital doors open communication 2As sales reps see doors close for in-person visits with physicians, digital doors open communication 3As sales reps see doors close for in-person visits with physicians, digital doors open communication 4As sales reps see doors close for in-person visits with physicians, digital doors open communication 5BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 2BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 3BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 4BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 5BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 6BioLife Solutions Announces the Addition of Jason Acker, MBA, PhD and Anthony Davies, PhD to its Scientific Advisory Board 7
... Perceptive Informatics ® , a leading eClinical ... (NASDAQ: PRXL ), today announced that its ... highest among EDC solutions for overall satisfaction in ISR,s ... independent study conducted by Industry Standard Research (ISR).  The ...
... 2011 Next Generation Pharmaceutical Manufacturing Europe ... Barcelona, Spain and will provide leading executives with an ... The summit has elected more than 50 of ... industry. Speakers will include Bo Hilligsøe, VP Finished Goods ...
Cached Medicine Technology:Perceptive Informatics® DataLabs® EDC Solution Ranks Highest in Overall Satisfaction 2Perceptive Informatics® DataLabs® EDC Solution Ranks Highest in Overall Satisfaction 3Perceptive Informatics® DataLabs® EDC Solution Ranks Highest in Overall Satisfaction 4Perceptive Informatics® DataLabs® EDC Solution Ranks Highest in Overall Satisfaction 5The Next Generation Pharmaceutical Manufacturing Summit 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: