Navigation Links
New study suggests link between estrogen exposure, high blood pressure
Date:5/26/2011

EAST LANSING, Mich. While recent studies have shown long-term exposure to estrogen can be a danger to women overturning physicians' long-held beliefs that the hormone was good for their patients' hearts the process by which estrogen induces high blood pressure was unclear.

In a new study, Michigan State University researchers found long-term estrogen exposure generates excessive levels of the compound superoxide, which causes stress in the body. The buildup of this compound occurs in an area of the brain that is crucial to regulating blood pressure, suggesting that the estrogen-induced buildup causes increased blood pressure.

Findings indicated that the anti-oxidant resveratrol reverses the increase in both superoxide and blood pressure.

The study, led by P.S. MohanKumar, an associate professor of pathobiology and diagnostic investigation in the College of Veterinary Medicine, appears in the American Journal of Physiology Regulatory, Integrative, and Comparative Physiology. The journal is published by the American Physiological Society.

"This is an important study on at least two levels," MohanKumar said. "First, it continues to confirm the negative effect that long-term estrogen exposure has for females. Second, it provides a new rationale for how and why this relationship occurs."

Researchers looked to the rostral ventrolateral medulla, a critical region in the brain stem involved with the maintenance of blood pressure and thought to be associated with hypertension and heart failure.

Believing that chronic exposure of estrogen could influence this area of the brain, they conducted a two-phase experiment using rats, injecting them first with estrogen and then also feeding them the anti-oxidant resveratrol. MohanKumar and his team found chronic exposure caused a significant increase in superoxide in the rostral ventrolateral medulla and in blood pressure. The team also found resveratrol reversed those increases.

"Because so many women use estrogen-only HRT to combat the effects of menopause, it is imperative that we better understand the risks that chronic exposure has for females and why these effects occur," he said. "In studies such as this, we come one step closer to clarifying the relationship and have established a launch pad for identifying how the process might be interrupted in the future."


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New study suggests link between estrogen exposure, high blood pressure
(Date:2/12/2016)... ... February 12, 2016 , ... According to an ... beginning to account for a significant portion of hernia repairs throughout the United States. ... Beverly Hills Hernia Center notes that this trend has not only been expected, but ...
(Date:2/12/2016)... ... 12, 2016 , ... CDRH Enforcement Trends: , Back to the Future , Feb. 25, 2016 ... Winston Churchill said, “Those who don’t learn from history are doomed to repeat it.” , ... come knocking this year. But that takes time. , Take a close look at ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a technology and ... the ISE Southeast Awards 2016. Finalists and winners of the ISE® Awards for ... Forum and Awards Gala on March 15, 2016 at the Westin Peachtree Plaza, ...
(Date:2/12/2016)... NC (PRWEB) , ... February 12, 2016 , ... AssureVest ... surrounding areas, is initiating a charity drive that will raise funds earmarked to purchase ... John C. Tayloe Elementary School. , “My school is in a low-income area and ...
(Date:2/12/2016)... ... February 12, 2016 , ... Donor Network West, the organ procurement organization ... a partnership with San Ramon Regional Medical Center. Under the collaboration, the first of ... way to accommodate a more certain time frame for donor families for the recovery ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... DPLO ) is pleased to announce the promotion of Paul Urick to Senior Vice ... To learn more about our Diplomat executive team, click ... ... ... In his redefined role at Diplomat, Urick ...
(Date:2/12/2016)... , Feb. 12, 2016   HeartWare International, ... conference call and webcast to discuss its financial results ... 2015, on Thursday, February 25, 2016 at 8:00 a.m. ... prior to the conference call and webcast.  On the ... financial results, highlights from the fourth quarter and business ...
(Date:2/12/2016)... , Feb. 12, 2016  Sequent Medical, Inc. ... a study to evaluate the safety and effectiveness of ... treatment of ruptured intracranial aneurysms.  Prof Laurent Spelle ... in Paris, France and Principal ... France and Germany.  Although ...
Breaking Medicine Technology: