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New study suggests cause of debilitating skin condition
Date:9/24/2007

rocedures using gadolinium. The researchers tested for the presence of TG2 in the skin samples.

Compared to the healthy subjects, there was a marked increase in TG2 in the subjects with NSF, said Sane. This suggests that activation of TG2 can produce the syndrome. TG2 is expressed in virtually all tissues and may explain why the fibrosis can occur in the heart and lungs, as well as the skin.

Sane said the results also suggest a strategy for preventing or treating NSF drugs such as cysteamine that inhibit the activation of TG-2.

Our research is a pilot study, but we believe the results warrant further research into the use of TG-2 inhibitors in the treatment and prevention of NSF, said Gil Yosipovitch, M.D., co-senior researcher, and a dermatologist. Solving this puzzle might allow dialysis patients to take full advantage of the diagnostic capabilities of MRI.

This could be a general mechanism for a broad range of disorders that involve fibrosis, or tissue thickening, said Sane.


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Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

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