Navigation Links
New study shows vitamin D-related 'molecular switches' predict childhood bone mass
Date:8/15/2013

Researchers at the MRC Lifecourse Epidemiology Unit, University of Southampton, have demonstrated that the degree to which a gene related to vitamin D action is switched on or off, when measured at birth, predicts bone density of the child at four years of age.

In the study, 230 boys and girls were assessed at 4 years as part of the Southampton Women's Survey (SWS), a large ongoing mother-offspring cohort. The children visited the Osteoporosis Centre at Southampton General Hospital for measurement of their bone size and density using a DXA scanner. The researchers were able to measure the extent to which a particular gene, RXRA, is switched on or off by measuring epigenetic marks on the DNA sequence of the gene in cells taken from umbilical cord tissue which had been collected at birth. They found that the less marking (which usually means greater gene activity), at birth, the greater the bone density of the child at four years old. Furthermore, one of the epigenetic marks was related to the mother's blood vitamin D concentrations in late pregnancy.

Dr Nicholas Harvey, Senior Lecturer at the MRC Lifecourse Epidemiology Unit, University of Southampton, who led this project said, "RXRA is essential for the action of vitamin D and several other hormones; taken together with the relationship we found between mothers' vitamin D levels and RXRA marking, this study provides further support for the potential importance of vitamin D in pregnancy. We are now testing whether mothers should be supplemented with vitamin D in pregnancy in a randomised controlled trial, the MAVIDOS Maternal Vitamin D Osteoporosis Study, which will report early next year."

Professor Cooper, Professor of Rheumatology and Director of the MRC Lifecourse Epidemiology Unit, University of Southampton and who oversaw this work, added "This study forms part of a larger programme of research at the MRC Lifecourse Epidemiology Unit and University of Southampton in which we ar
'/>"/>

Contact: L. Misteli
info@iofbonehealth.org
41-229-940-100
International Osteoporosis Foundation
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researcher awarded $1.8 million grant to study gender differences in antidepressant effects
2. Birmingham Maple Clinic Releases Study on CTFD Phenomenon
3. Study examines risk of severe blood sugar swings among diabetics taking fluoroquinolones
4. International Probiotics Association Objects to Media Depiction of AAD/CDD Study, Provides Further Insight to Study Results
5. UCLA Dentistry receives $5 million to study extracellular RNA in saliva
6. Pilot study finds ER patients drinking high-octane beer
7. Pradaxa Lawsuit Lawyers at Wright & Schulte LLC Disturbed by New Study Finding that Pradaxa Users Face Significantly Higher Risk of Bleeding Side-Effects
8. Study challenges popular perception of new hookup culture on college campuses
9. Study examines how truck drivers react to marketplace demands for speed and flexibility
10. Study finds that some depressed adolescents are at higher risk for developing anxiety
11. Onsite colposcopy clinic improves cancer screening rates: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... treat children with uncomplicated acute appendicitis is a reasonable ... fewer missed school days, according to a pilot study. ... Hospital and published online April 12 in the ... the first prospective study on nonoperative management of acute ... , Researchers enrolled 77 patients age 7 to 17 ...
(Date:4/14/2014)... 2014, Perth, Australia. Drug discovery company Proteomics International ... of a companion diagnostic (CDx) test with the ... The research team authenticated the panel of biomarkers ... samples. Seven biomarkers were validated at high stringency ... The mass spectrometry data was then cross-validated using ...
(Date:4/14/2014)... 2014) When it comes to the cost and ... Patients get the best care when they are treated ... extensive experience in their current job, according to a ... and Columbia Business School. The study was published in ... Applied Economics . , The review of more ...
(Date:4/13/2014)... STANFORD, Calif. A low-cost empowerment program for ... and sexual harassment of these girls, who live ... and are frequently attacked, a large new study ... Stanford University School of Medicine, Lucile Packard Children,s ... No Worldwide, validated the program,s effectiveness in combating ...
(Date:4/11/2014)... the processes that control brain cell production could pave ... brain-related disorders. , Scientists have gained new understanding of ... how and when nerve and brain cells are formed ... and keeps it healthy. Their findings could help explain ... which is a fundamental characteristic of many diseases including ...
Breaking Medicine News(10 mins):Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 2Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 3Health News:Longer nurse tenure on hospital units leads to higher quality care 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 3Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 4
... Retina, it has been found that a drug, which ... effective// in treating cystoid macular edema (CME), a common ... two patients with severe retinal swelling who were not ... Avastin, works in colorectal cancer by inhibiting the blood ...
... found that intake of foods during pregnancy plays a vital ... intake of diet// and behavior of child are interrelated, and ... less nutritious food at the time of pregnancy. ,Dr. ... study, which found that children born to iron-deficient teenage mothers ...
... Hospitals Trust has been fined ?100,000 after pleading guilty ... 31 following a routine operation//. The trust has pleaded ... ,Sitting at Winchester Crown Court, Mr Justice ... costs following the health and safety prosecution prompted by ...
... of the NHS, Sir Ian Carruthers, has proposed cost cutting ... ,He proposes to unveil his plan at a No ... believes the ?10.3 billion spent every year on drugs and ... Fears that patients would not be given expensive treatments from ...
... the William Harvey Research Institute has ... dark chocolate on heart patients//. He ... trial once he gets the regulatory ... with cardiovascular disease will be tested ...
... & Lomb Inc's brand cleansing solution has been linked to ... cause blindness//. Optometry doctors in the U.S have urged contact ... , Bausch & Lomb Inc. has ... since Monday following warnings from the U.S. Food and Drug ...
Cached Medicine News:Health News:Hospital Trust Fined ?100,000 after Patient Deat 2
(Date:1/15/2014)... , Jan. 15, 2014  Research and Markets ... the "Dental Consumables Market - Global Industry ... - 2018" report to their offering. ... ) Dental consumables are products which are ... impairments, for tooth restoration and in treatment of ...
(Date:1/15/2014)... , Jan. 15, 2014  Novation, the leading ... company, awarded several new IT value-added reseller (VAR) ... hospital organizations with IT goods and services at ... agreements, as well as value-added services such as ... New Novation agreements were awarded to ...
(Date:1/15/2014)... DUBLIN , January 15, 2014 ... that it has waived the Office of Fair Trading (OFT) ... the outstanding shares of ViroPharma Incorporated (NASDAQ: VPHM).   ... no longer conditional on OFT approval, and Shire expects to ... currently scheduled expiration time, subject to the satisfaction of all ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
... CINCINNATI, July 7 Procter & Gamble Pharmaceuticals (P&GP) ... tablets, which are indicated for the treatment of moderately ... disease. UC involves inflammation of the lining of the ... followed by periods of remission. Moderately active UC is ...
... Tenn., July 6 /PRNewswire/ -- A Pebble Beach ... cure for multiple sclerosis. The researchers took home the top ... and the non-profit Band Against MS (BAMS) organization. The money ... at the University of Texas Health Science Center at ...
Cached Medicine Technology:Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets 2Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets 3Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets 4Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets 5Clay Walker's Band Against MS Foundation Donates $150,000 To Support Multiple Sclerosis Research 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: