Navigation Links
New study shows promise for preventing therapy resistance in tumor cells
Date:1/9/2014

LEXINGTON, Ky. (Jan. 9, 2013) A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par-4, another potent tumor suppressor protein that induces cell death in cancer cells. This finding may help researchers decipher how to inhibit the growth of tumors that have become resistant to other treatments.

Loss of the tumor suppressor p53 often contributes to therapy resistance in tumors. In the study, published in Cell Reports, the University of Kentucky's Vivek Rangnekar and his colleagues activated wild type p53 in normal cells to trigger cell death in the p53-deficient cancer cells. Because p53 is intact and functional in normal cells, the researchers harnessed its potential to inhibit the growth of p53-deficient cancer cells.

This paracrine effect was brought about by the tumor suppressor Par-4, which specifically kills cancer cells. Although other tumor suppressors exist, what makes Par-4 so special is that it is not mutated as frequently as other known suppressors, and it's "selective" in its actions in that Par-4 will only kill cancer cells and not normal cells. Importantly, it's secretion from normal cells can be induced by activating p53 so that Par-4 enters circulation, thereby potentially targeting tumor cells at distant sites.

"As normal cells far outnumber the cancer cells in patients, we sought to empower the normal cells to trigger cell death in p53-deficient cancer cells," said Rangnekar, associate director of transdisciplinary collaborations for the UK Markey Cancer Center. "Our findings have potential for targeting local, as well as metastatic tumors, and future studies will use FDA-approved drugs to induce Par-4 secretion."


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Page: 1

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... 2014 Written and narrated by award winning ... releases the “The Happiest Man In the World: Life ... of how and why Project C.U.R.E. came to be. , ... Josie and the Reverend Richard W. Jackson, Dr. Jackson exceeded ... 30, but realized that he wasn’t happy. Prompted by this ...
(Date:11/28/2014)... Austin, Texas (PRWEB) November 28, 2014 ... of prediabetes testing and treatment, helped employees learn ... complimentary on-site diabetes blood screening at a local ... Stop Diabetes @ Work initiative. , As ... @ Work program , PreDiabetes Centers is co-hosting ...
(Date:11/28/2014)... Everett, WA (PRWEB) November 28, 2014 ... Snohomish County provides an overview of the influenza virus that ... annual flu season. , The article begins with a ... it manifests its symptoms. It reminds families that children under ... and those suffering from chronic diseases, such as heart and ...
(Date:11/28/2014)... 28, 2014 An inventor from Flint, Mich., ... day. "I got this idea while lying in a hospital ... he said. , The Bed Buddy provides a more ergonomic ... the bathroom. It eliminates the need to leave the bed, ... and dignity. Easy to use and producible in design variations, ...
(Date:11/28/2014)... Most of the people attending a presentation by Ken ... Prince Woods retirement community found out the “prized” possessions ... wouldn’t have made the cut to be on an “Antiques ... decorative and folk art and his appearances on the PBS ... buying and selling antiques. Broadly speaking the antiques market ...
Breaking Medicine News(10 mins):Health News:Thanksgiving Weekend Audiobook Treat! “The Happiest Man In the World: Life Lessons From a Cultural Economist” by Dr. James W. Jackson 2Health News:PreDiabetes Centers Offers Workplace Diabetes Screening at Local School 2Health News:How Flu Vaccines Can Impact Families Is Discussed in New Article from Community Health Center of Snohomish County 2Health News:Antiques Appraiser Sheds Light on "Treasures" 2
... AlertSite(R), a leading,provider of web site performance ... for their customers, announced today that,iHerb.com has chosen ... a major online retailer of brand name nutritional ... ConsumerLab.com as the #1 Online,Supplement Retailer, based on ...
... NEW YORK, Feb. 26 "It is not ... water outweigh risks of,neurodevelopment or other effects such ... Environmental Health report.(1), Fluoride chemicals are added ... reduce tooth decay. Fluoride is found in dental ...
... Feb. 26 With over five million Americans,suffering from ... cases,diagnosed every year, it is the number one cause ... a yearly direct cost of care,estimated at $100 billion, ... Device Markets., Improvements in the care of other ...
... About Medicare, Health Insurance Options, KANSAS CITY, ... boomers turn 62 this year and begin claiming ... the National Association of Insurance,Commissioners (NAIC), many are ... Medicare eligibility., The NAIC,s national survey of ...
... offers a breakthrough in advancing, apoptosis-related research ... medicine, ST. LOUIS, Feb. 26 Sigma-Aldrich(TM) ... that they,have signed a licensing agreement for a ... apoptosis in vitro and in vivo in animals. ...
... Income from Operations, LOVELAND, Colo., Feb. 26 Heska ... fourth quarter, the,three months ended December 31, 2007, and year ... ), Heska Corporation ("Heska" or the "Company") highlights for ... - the highest total revenue in Heska ...
Cached Medicine News:Health News:Top Nutritional Supplement Online Retailer, iHerb.com, Selects AlertSite for Web Site Performance Monitoring 2Health News:Fluoride May Damage the Brain, New Report Says 2Health News:'Hidden Epidemic' of Congestive Heart Failure Driving Hospitalization, Costs 2Health News:Baby Boomers Confused About Medicare, According to Recent NAIC Survey 2Health News:Baby Boomers Confused About Medicare, According to Recent NAIC Survey 3Health News:Baby Boomers Confused About Medicare, According to Recent NAIC Survey 4Health News:Baby Boomers Confused About Medicare, According to Recent NAIC Survey 5Health News:Baby Boomers Confused About Medicare, According to Recent NAIC Survey 6Health News:Sigma-Aldrich Licenses From NeuroSurvival Technologies a Leading Marker for Molecular Imaging of Apoptosis in Vivo 2Health News:Sigma-Aldrich Licenses From NeuroSurvival Technologies a Leading Marker for Molecular Imaging of Apoptosis in Vivo 3Health News:Heska Announces Q4 and Annual 2007 Results 2Health News:Heska Announces Q4 and Annual 2007 Results 3Health News:Heska Announces Q4 and Annual 2007 Results 4Health News:Heska Announces Q4 and Annual 2007 Results 5Health News:Heska Announces Q4 and Annual 2007 Results 6Health News:Heska Announces Q4 and Annual 2007 Results 7Health News:Heska Announces Q4 and Annual 2007 Results 8Health News:Heska Announces Q4 and Annual 2007 Results 9Health News:Heska Announces Q4 and Annual 2007 Results 10
(Date:11/26/2014)... , November 26, 2014 A ... of the organ protrudes through the wall of a weak ... area at birth are some of the causes of hernias. ... hiatal, femoral, and incisional. An inguinal hernia is when part ... umbilical hernia is found in the area of the umbilicus. ...
(Date:11/26/2014)... , Nov. 26, 2014  Aridis Pharmaceuticals, ... produce novel therapies for infectious diseases, announced today ... an internationally recognized key opinion leader in the ... scientific advisory board. Founder and Chief ... "We believe Dr. Opal,s extensive experience investigating bacterial ...
(Date:11/26/2014)... 25, 2014 According to ... Power Source (Electric, Battery, Pneumatic), by Product (Drill, ... Cart), by Application (Orthopedic, ENT, Oral, Thoracic, Neurology) ... global Powered Surgical Instruments Market is estimated to ... 2014 and is expected to grow at a ...
Breaking Medicine Technology:Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 2Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 3Global Hernia Repair Devices Market Size, Share, Trends and Forecast 2014 to 2018 - Big Market Research 4Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4
... Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ) announced ... the Citi 2012 Global Health Care Conference on Wednesday, February ... Time) at the Waldorf=Astoria in New York City. Jack Lief, ... a corporate overview. A live audio webcast of ...
... Switzerland, Feb. 23, 2012  Auxilium Pharmaceuticals, Inc. ... Pharmaceuticals Ltd. (SWX: ATLN.S) announced today that ... for the development, supply and commercialization of ... biologic for the potential treatment of Dupuytren,s ...
Cached Medicine Technology:Arena Pharmaceuticals to Present at the Citi 2012 Global Health Care Conference 2Arena Pharmaceuticals to Present at the Citi 2012 Global Health Care Conference 3Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 2Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 3Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 4Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 5Auxilium Pharmaceuticals, Inc. and Actelion Pharmaceuticals Ltd. Enter a Collaboration Agreement for XIAFLEX® in Canada, Australia, Brazil and Mexico 6
These are the Reusable Components (minus cannula), to be used with the VersaStep™ Plus Reposable Short System....
The VersaStep™ 5 mm and VersaStep™ PLUS Reposable system components for creating each access port are supplied in separate packages....
VersaStep™ Reposable Sterilization Trays....
... Instrument for applications in ... ,The VERSASTEP™ Plus instrument ... length is a unique ... radial dilation. It is ...
Medicine Products: