Navigation Links
New study shows promise for developing new treatments for breast cancer
Date:3/14/2012

LEXINGTON, Ky. (March 14, 2012) A new study by University of Kentucky researchers provides insight into developing new treatment strategies for basal-like breast cancer, commonly known as triple-negative breast cancer. This cancer is associated with early metastasis and resistance to chemotherapy and occurs at women at a younger age.

Tumor cells can exploit a cellular program that promotes cell migration and reduces adhesion between cells to spread to distant sites in the body. This cellular program, known as the epithelial-mesenchymal transition, requires large-scale cell movement during embryonic development, tissue remodeling and wound healing. Tumor cells take over this developmental program for their cell movement during invasion and metastasis.

In this EMT process, expression of a cell-to-cell adhesion molecule called E-cadherin, which functions as a "molecular glue" that binds cells to one another, needs to be downregulated in order for cells to disassociate from each other and spread throughout the body. A protein called Snail acts as a master switch in the cell's nucleus to suppress E-cadherin expression and induce EMT in the cell. However, how Snail achieves this task remains unclear. Understanding this molecular mechanism will help to develop novel agents to disrupt this EMT event for treating metastatic breast cancer.

The study, recently published online in the Journal of Clinical Investigation, identified that Snail interacted with a chromatin modifying enzyme G9a and recruited G9a to the E-cadherin promoter. This action closes the gene structure of E-cadherin and thus results in the suppression of "molecular glue" E-cadherin expression. The findings establish that the interaction of Snail with G9a is an important determinant of metastasis in triple-negative breast cancer.

"This finding has significant clinical ramification, because chemical compounds or agents that can disrupt the interaction of Snail with G9a will have a great therapeutic potential of treating triple-negative breast cancer," said UK's Peter Zhou, principal investigator for the study. "Investigators at the Markey Cancer Center are currently exploring this idea and are keen to develop drugs that can treat triple-negative breast cancer."

Triple-negative breast cancer is the worst subtype of breast cancer. This subtype of breast cancer has poor clinical outcome due to the early metastasis of tumor cells and the lack of specific drugs that target it.

"An understanding of the mechanism underlying the biology of metastasis in triple-negative breast cancer will provide novel therapeutic approaches to combat this life-threatening disease," Zhou said.


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2017)... ... 27, 2017 , ... For bicycling enthusiasts around the globe, Germany's famous Rad ... place against a backdrop of tree-lined hills at the Nürburgring, a Formula One arena ... am Ring consists of some 73 curves, stretching out over more than 500 meters ...
(Date:7/27/2017)... ... July 27, 2017 , ... ... secure cloud-based polysomnography (PSG) distributed scoring solution to its healthcare management platform. This ... care management. The speed and functionality of scoring in the cloud is on ...
(Date:7/27/2017)... Plano, TX (PRWEB) , ... July 27, 2017 ... ... technology and outsourced services, announces the internal promotion of Elrene Clinkscales to Vice ... Operations – Claims & Remittance Management, reporting to Derek Morkel, chief executive officer ...
(Date:7/27/2017)... , ... July 27, 2017 , ... ... as a finalist in this year’s Fierce Innovation Awards: Healthcare Edition 2017, an ... finalist in the category of Population Health Management/Patient Engagement Solutions. , MAP ...
(Date:7/27/2017)... ... , ... Cremations recently surpassed traditional burials for the first time in the ... continue with over 70% of Americans projected to choose cremation by 2030. , In ... families to celebrate the life of a lost loved one in different ways using ...
Breaking Medicine News(10 mins):
(Date:7/27/2017)... 27, 2017  West Pharmaceutical Services, Inc. (NYSE: ... the second-quarter 2017 and updated financial guidance for the ... 2017 Highlights Reported net sales of ... prior-year quarter. Net sales at constant currency (organic) grew ... was $0.51, compared to $0.60 in the prior-year quarter. ...
(Date:7/25/2017)... Massachusetts , July 25, 2017 The med-tech ... rare nervous system diseases, has concluded a worldwide license agreement ... drug SOM0226 against transthyretin amyloidosis (ATTR). Before this licensing agreement ... a Phase 2 study conducted in Europe ... the United States ...
(Date:7/21/2017)... SILVER SPRING, Md. and RESEARCH ... -- United Therapeutics Corporation (NASDAQ: UTHR ) ... 2017 financial results before the market opens on Thursday, ... United Therapeutics will host a teleconference on Thursday, July ... is accessible by dialing 1-877-351-5881, with international callers dialing ...
Breaking Medicine Technology: