Navigation Links
New study shows promise for analyzing bladder pain syndrome
Date:2/23/2012

LEXINGTON, Ky. (Feb. 23, 2012) -- A pilot study led by University of Kentucky researchers shows that the gene expression analysis of urine sediment could provide a noninvasive way to analyze interstitial cystitis in some patients.

Interstitial cystitis, also known as bladder pain syndrome, is a debilitating disease of the urinary bladder. The disease can occur with or without bladder ulcers (called Hunner lesions). Interstitial cystitis is a difficult disease to study because animal models are limited, and human patients cannot ethically be subjected to invasive research procedures.

The researchers' goal was to develop a noninvasive method to analyze the bladder epithelium as objectively and directly as possible. During the study, the researchers used microarray technology to analyze cells shed into the urine as an alternative to bladder biopsies, which require anesthesia and have a small risk of bladder injury.

The results showed that urine cells from patients with Hunner lesions had a distinct gene signature for inflammation, similar to the results from a prior microarray study of bladder biopsies. The study was the first to show this inflammation objectively, but without biopsy, in Hunner lesion patients.

If these preliminary results are validated in future research, they may lead to a noninvasive biomarker for Hunner lesion-interstitial cystitis/bladder pain syndrome, says researcher Eric Blalock, associate professor in the Department of Molecular and Biomedical Pharmacology at the UK College of Medicine.

"A crucial next step will be to determine the stability of this set of biomarkers across larger samples of the population," Blalock said. "And to also see if similar procedures could be used for early diagnosis and intervention in the disease process."

For interstitial cystitis patients without Hunner lesions, the gene signatures were similar to healthy controls.

"This is important in view of the ongoing debate whether the two types of interstitial cystitis really are different disorders," said UK urologist Deborah Erickson. "Prior studies showed the two patient types did have different findings on bladder biopsies. Our findings support the difference, but without the need for biopsy."

The study was published in the February issue of the Journal of Urology and was also selected for post-publication in the Faculty of 1000 (F1000), a global peer review group that identifies and evaluates the most important articles in biology and medical research publications. Selection places a researcher's work in F1000's library of the top 2 percent of published articles in biology and medicine.


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Related medicine news :

1. Medicare and Medicaid CT scan measure is unreliable according to new BWH study
2. Mammograms Can Save Lives of Women in Their 40s: Study
3. Study finds some insulin production in long-term Type 1 diabetes
4. Stronger intestinal barrier may prevent cancer in the rest of the body, new study suggests
5. Aspirin as Good as Plavix for Poor Leg Circulation: Study
6. Study: No Significant Rise in Seizure Risk From Common Kids Vaccine
7. Study: Brain makes call on which ear is used for cell phone
8. Cedars-Sinai awarded $2.5 million to study potential new drug treatments for Alzheimers disease
9. Worries About Colonoscopy Unfounded: Study
10. Perception, work-life balance key factors in workplace safety, says UGA study
11. Kids With Crohns Disease, Colitis Often Struggle at School: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... February 20, 2017 , ... Silverado today is pleased ... open and operate a state-of-the-art memory care community in Alexandria, Virginia. The new community ... site just outside of Old Town. , The three-story community with underground parking ...
(Date:2/20/2017)... Pittsburgh, PA (PRWEB) , ... February 20, 2017 , ... ... mechanism of thyroid cancer, as well as a marker that may predict response to ... those with many other types of cancer as well. The new findings were published ...
(Date:2/20/2017)... ... February 20, 2017 , ... Today, ... Document Router (BDR), the first IoT device from Biscom designed to deliver confidential ... will debut BDR at HIMSS17 and will be conducting demonstrations at ...
(Date:2/20/2017)... ... 2017 , ... ReportingMD, a Population Health Software Company, is pleased to announce a move to ... location will triple the size of the previous location while bringing life back to a ... , “We are excited to expand our footprint to better serve our growing client ...
(Date:2/20/2017)... , ... February 20, 2017 , ... Chuck E. Cheese’s® ... Sensitive Sundays, a joint event at Chuck E. Cheese’s locations throughout New England, New ... special needs, the opportunity to experience the fun of visiting Chuck E. Cheese’s in ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... , February 20, 2017 ...  is anticipated to reach USD 1.4 billion by ... View Research, Inc. Constant evaluation of various techniques ... expected to drive growth in this market. Moreover, ... development of novel and improved shunts in order ...
(Date:2/20/2017)... New York , February 20, 2017 ... regularized absorption of calcium and phosphorous minerals in one,s ... of vitamin D ingredients in maintaining a healthy composition ... medicines containing vitamin D ingredients is growing in the ... advantage of consuming vitamin D ingredients for treatment of ...
(Date:2/19/2017)... , Feb. 19, 2017   AC Group ... selection, and ranking of vendors in the PMS/EHR healthcare ... and implementational system requirements to succeed in this ecosystem ... Group gathered together information obtained from over 200 ACOs, ... technology software and services companies that are providing different ...
Breaking Medicine Technology: