Navigation Links
New study shows promise for analyzing bladder pain syndrome
Date:2/23/2012

LEXINGTON, Ky. (Feb. 23, 2012) -- A pilot study led by University of Kentucky researchers shows that the gene expression analysis of urine sediment could provide a noninvasive way to analyze interstitial cystitis in some patients.

Interstitial cystitis, also known as bladder pain syndrome, is a debilitating disease of the urinary bladder. The disease can occur with or without bladder ulcers (called Hunner lesions). Interstitial cystitis is a difficult disease to study because animal models are limited, and human patients cannot ethically be subjected to invasive research procedures.

The researchers' goal was to develop a noninvasive method to analyze the bladder epithelium as objectively and directly as possible. During the study, the researchers used microarray technology to analyze cells shed into the urine as an alternative to bladder biopsies, which require anesthesia and have a small risk of bladder injury.

The results showed that urine cells from patients with Hunner lesions had a distinct gene signature for inflammation, similar to the results from a prior microarray study of bladder biopsies. The study was the first to show this inflammation objectively, but without biopsy, in Hunner lesion patients.

If these preliminary results are validated in future research, they may lead to a noninvasive biomarker for Hunner lesion-interstitial cystitis/bladder pain syndrome, says researcher Eric Blalock, associate professor in the Department of Molecular and Biomedical Pharmacology at the UK College of Medicine.

"A crucial next step will be to determine the stability of this set of biomarkers across larger samples of the population," Blalock said. "And to also see if similar procedures could be used for early diagnosis and intervention in the disease process."

For interstitial cystitis patients without Hunner lesions, the gene signatures were similar to healthy controls.

"This is important in vi
'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Medicare and Medicaid CT scan measure is unreliable according to new BWH study
2. Mammograms Can Save Lives of Women in Their 40s: Study
3. Study finds some insulin production in long-term Type 1 diabetes
4. Stronger intestinal barrier may prevent cancer in the rest of the body, new study suggests
5. Aspirin as Good as Plavix for Poor Leg Circulation: Study
6. Study: No Significant Rise in Seizure Risk From Common Kids Vaccine
7. Study: Brain makes call on which ear is used for cell phone
8. Cedars-Sinai awarded $2.5 million to study potential new drug treatments for Alzheimers disease
9. Worries About Colonoscopy Unfounded: Study
10. Perception, work-life balance key factors in workplace safety, says UGA study
11. Kids With Crohns Disease, Colitis Often Struggle at School: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... Pittsburgh, PA (PRWEB) October 20, 2014 ... new, minimally-invasive procedure that enables physicians to repair a ... , The MitraClip system, developed by ... regurgitation (MR), a progressive and life-threatening condition in which ... allowing blood to flow backward from the heart’s left ...
(Date:10/20/2014)... 2014 T.E.N., a technology and ... today that William H. Murray, renowned author and ... Luminary Leadership Award winner. Presented annually, the ISE® ... outstanding leader and industry practitioner for his or ... the information security industry. , Formerly with IBM, ...
(Date:10/20/2014)... 2014 My Clients Plus ( http://www.MyClientsPlus.com ... The new module enables easy administration and routing ... quality care. , This application allows users such as ... attach a to-do item to a specific client, categorize ... up reoccurring reminders for follow-ups. It's designed to ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Rockynol ... Living Center on Oct. 14. The $11 million project ... services, and a cooked-to-order kitchen with full-service restaurant style ... premier choice for first class Assisted Living apartments,” said ... residents deserve the highest quality of care and this ...
(Date:10/20/2014)... Final Cut Pro X Plugin developers from Pixel Film ... FCPX filmmakers . , “Fun, cool, and simple are ... Says Christina Austin, CEO of Pixel Film Studios. “It has ... comes with all the tools needed for a full ... added style, a title screen for an introduction, two lower ...
Breaking Medicine News(10 mins):Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2
... ... Pole Fitness, Women’s Answer to a Male Dominated Gym scene. Embody Pole gives the women ... ... notion of physical fitness were completely male-centered. Where do women go when they want to ...
... for spike between 2008 and 2009, analysis finds , ... injuries appear to be on the rise, warns the ... sports and baseball/softball are the main culprits. , The ... trends as they transpired between 2008 and 2009, based ...
... disease remission in patients with rheumatoid arthritis (RA) ... including work productivity and quality of life according ... Annual Congress of the European League Against Rheumatism ... reported in addition to improvements in measures of ...
... drinkers were 39% less likely to get these malignancies ... help protect against head and neck cancers, a new ... the International Head and Neck Cancer Epidemiology consortium. They ... a day) were 39 percent less likely to develop ...
... cost of brain-tumor surgery might both be reduced if surgery ... procedure, according to a new study conducted at The Ohio ... Richard J. Solove Research Institute. The study, published online June ... outcomes of 39 patients treated for glioma, a type of ...
... being a good dad, expert suggests , FRIDAY, June 18 ... new ties and other tokens of gratitude, they might think ... a promise that they,ll watch their health, suggests a family ... die younger than women and are more likely to die ...
Cached Medicine News:Health News:“Embody Pole Fitness” Puts a Sexy Spin on Fitness in the Inland Empire 2Health News:Bump in Head Injury Numbers Linked to Summer Play 2Health News:Targeting disease remission has socio-economic benefits over low disease activity 2Health News:Targeting disease remission has socio-economic benefits over low disease activity 3Health News:Awake sedation for brain surgery may shorten hospital stay 2Health News:On Father's Day, Give Dad Gift of Health 2
(Date:10/20/2014)... , Oct. 20, 2014  AnaptysBio, Inc., ... therapeutic antibodies, today announced the appointment of ... Dr. Londei will lead the preclinical and clinical ... "We are pleased to welcome Dr. Londei ... Suria , President and Chief Executive Officer of ...
(Date:10/20/2014)... 20, 2014   Mary,s Medicinals today announced ... a 4-Star Sponsor of Operation Grow4Vets , a ... products, programs and services to assist them in living ... Key Facts: , An ever-increasing number of ... and effective treatment for pain, Post-traumatic Stress Disorder (PTSD) ...
(Date:10/19/2014)... SEATTLE, Wash. , Oct. 20, 2014 ... today that it will report its third quarter 2014 ... close of the U.S. financial markets. Following the announcement, ... conference call to discuss the results and provide a ... PDT). Access to the event can be obtained as ...
Breaking Medicine Technology:AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 3CTI BioPharma to Report Third Quarter 2014 Financial Results on October 29, 2014 2
Heine Beta 200 Streak Retinoscope 2.5v...
Keeler Professional Combi Retinoscope with new slimline handle and lithium or dry cell option....
System, English (Continental cord), 230 VAC....
Micro-mini fiber optic light....
Medicine Products: