Navigation Links
New study shows promise for analyzing bladder pain syndrome
Date:2/23/2012

LEXINGTON, Ky. (Feb. 23, 2012) -- A pilot study led by University of Kentucky researchers shows that the gene expression analysis of urine sediment could provide a noninvasive way to analyze interstitial cystitis in some patients.

Interstitial cystitis, also known as bladder pain syndrome, is a debilitating disease of the urinary bladder. The disease can occur with or without bladder ulcers (called Hunner lesions). Interstitial cystitis is a difficult disease to study because animal models are limited, and human patients cannot ethically be subjected to invasive research procedures.

The researchers' goal was to develop a noninvasive method to analyze the bladder epithelium as objectively and directly as possible. During the study, the researchers used microarray technology to analyze cells shed into the urine as an alternative to bladder biopsies, which require anesthesia and have a small risk of bladder injury.

The results showed that urine cells from patients with Hunner lesions had a distinct gene signature for inflammation, similar to the results from a prior microarray study of bladder biopsies. The study was the first to show this inflammation objectively, but without biopsy, in Hunner lesion patients.

If these preliminary results are validated in future research, they may lead to a noninvasive biomarker for Hunner lesion-interstitial cystitis/bladder pain syndrome, says researcher Eric Blalock, associate professor in the Department of Molecular and Biomedical Pharmacology at the UK College of Medicine.

"A crucial next step will be to determine the stability of this set of biomarkers across larger samples of the population," Blalock said. "And to also see if similar procedures could be used for early diagnosis and intervention in the disease process."

For interstitial cystitis patients without Hunner lesions, the gene signatures were similar to healthy controls.

"This is important in view of the ongoing debate whether the two types of interstitial cystitis really are different disorders," said UK urologist Deborah Erickson. "Prior studies showed the two patient types did have different findings on bladder biopsies. Our findings support the difference, but without the need for biopsy."

The study was published in the February issue of the Journal of Urology and was also selected for post-publication in the Faculty of 1000 (F1000), a global peer review group that identifies and evaluates the most important articles in biology and medical research publications. Selection places a researcher's work in F1000's library of the top 2 percent of published articles in biology and medicine.


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert

Related medicine news :

1. Medicare and Medicaid CT scan measure is unreliable according to new BWH study
2. Mammograms Can Save Lives of Women in Their 40s: Study
3. Study finds some insulin production in long-term Type 1 diabetes
4. Stronger intestinal barrier may prevent cancer in the rest of the body, new study suggests
5. Aspirin as Good as Plavix for Poor Leg Circulation: Study
6. Study: No Significant Rise in Seizure Risk From Common Kids Vaccine
7. Study: Brain makes call on which ear is used for cell phone
8. Cedars-Sinai awarded $2.5 million to study potential new drug treatments for Alzheimers disease
9. Worries About Colonoscopy Unfounded: Study
10. Perception, work-life balance key factors in workplace safety, says UGA study
11. Kids With Crohns Disease, Colitis Often Struggle at School: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... ... Mountains to Climb: A Journey of Love and Faith Through Trials”: a gripping ... shared to overcome struggles in life. “Our Mountains to Climb: A Journey of Love ... retired teacher and happily married since 1999; the author’s personal experiences drive this narrative. ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Beyond Our Imaginations: The ... “Beyond Our Imaginations: The Infinite God” is the creation of published author, Mark Lawrence, ... country. , Lawrence shares, “The problem with becoming a greater man of God is ...
(Date:8/18/2017)... ... 18, 2017 , ... “Kingdom Mandate for Kingdom Builders”: a call to walk ... Kingdom Builders” is the creation of published author, John F. McGeorge, Jr. Dr. ... missionary in 1983. He spent three decades training pastors and Christian leaders. ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Case #10-5411 Veterans Administration”: a ... “Case #10-5411 Veterans Administration” is the creation of published author, Carol Mulhern, ... 1990, Carol Mulhem started work at the Coatesville VAMC as a file clerk ...
(Date:8/17/2017)... ... August 17, 2017 , ... The award-winning producers of the ... National Council for Therapeutic Recreation Certification (NCTRC), slated to air nationwide, fourth quarter ... is a non-profit, international organization dedicated to professional excellence for the protection of ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... that its Board of Directors has approved the payment of ... of 2017. The cash ... about October 27, 2017 to stockholders of record as of ... of dividends are subject to approval of the Board of ...
(Date:8/7/2017)... Mich., Aug. 7, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), ... the quarter ended June 30, 2017.  All comparisons, unless otherwise ... Second Quarter 2017 Highlights ... to $1,089 million, an increase of 3.5% ... Gross margin of 7.5% versus 7.6% ...
(Date:8/4/2017)... Md. , Aug. 4, 2017 The ... or shortly after a physician/patient consult has long been ... and was a notable focus of the largest meeting ... is according to healthcare market research firm Kalorama Information. ... care testing (POCT) offerings or related supplies and software ...
Breaking Medicine Technology: