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New study shows potential to treat or prevent viral cancers
Date:6/16/2008

immunotherapy of infectious diseases and cancers. The study involved treating experimental cervical cancer and hepatocellular carcinoma in nude mice with antibodies to respective viral antigens expressed on these tumors. The antibodies were radiolabeled with 188-Rheniuma powerful beta-emitting radionuclide. "This study demonstrates a real possibility for more specifically targeted cancer treatments," said Dadachova. "Targeting those antigens with radiolabeled molecules offers exquisite specificityand will hopefully allow us to significantly increase the efficacy of treatment by administering more individualized doses while avoiding toxicity."

"Nuclear medicine and molecular imaging offer the ability to target disease on a truly molecular level that is unmatched by any other imaging or therapeutic modality," said Dadachova. "Targeting viral antigens with radiolabeled antibodies (or also with specific peptides or aptamers) will allow the extremely precise diagnosis of such cancers and their effective therapy. Furthermore, this approach will make possible 'molecular prevention' of viral cancers, when infected cells will be targeted before they become cancerous."


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Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

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