Navigation Links
New study shows potential to treat or prevent viral cancers
Date:6/16/2008

NEW ORLEANS, La.A new study, presented at the SNM 55th Annual Meeting, shows that radioimmunotherapy (RIT) targeting viral antigens offers a novel option to treator even preventmany viral cancers by targeting cancer cells expressing viral antigens or infected cells before they convert into malignancy.

"There is an urgent need to find new approaches to treating and preventing viral cancers," said Ekaterina (Kate) Dadachova, associate professor of nuclear medicine and microbiology and immunology at Albert Einstein College of Medicine, Bronx, N.Y. and lead researcher of the study, Viral Antigens as Novel Targets for Radioimmunotherapy of Viral Cancers. "The magnitude and global health-burden associated with viral cancers is only now being realized."

It is estimated that up to 25 percent of all cancers are currently linked to existing viral infections. Most of these cancers are extremely difficult to treat and cannot successfully be reduced or removed using conventional therapies or treatments. Viral cancers include cervical cancers caused by infection with a human papillomavirus (HPV), a sexually transmitted disease; hepatocellular carcinoma (HCC), a cancer of the liver; various lymphomas and carcomas in patients with AIDS/HIV; and other cancers.

According to Dadachova, this is the first time that researchers have attempted to target viral antigens on cancers, although the use of RIT for the treatment of cancer has been under development for thirty years. However, the targets of RIT therapy to date have included only "self" human antigens, which are overexpressed on the tumors but also expressed on normal tissues. Viral antigens, on the contrary, are expressed only on the tumors and nowhere else in the body.

The idea to perform the study was suggested by Dr. Arturo Casadevall, chair of the department of microbiology and immunology at Albert Einstein College of Medicine, who collaborates with Dadachova on developing radioimmunotherapy of infectious diseases and cancers. The study involved treating experimental cervical cancer and hepatocellular carcinoma in nude mice with antibodies to respective viral antigens expressed on these tumors. The antibodies were radiolabeled with 188-Rheniuma powerful beta-emitting radionuclide. "This study demonstrates a real possibility for more specifically targeted cancer treatments," said Dadachova. "Targeting those antigens with radiolabeled molecules offers exquisite specificityand will hopefully allow us to significantly increase the efficacy of treatment by administering more individualized doses while avoiding toxicity."

"Nuclear medicine and molecular imaging offer the ability to target disease on a truly molecular level that is unmatched by any other imaging or therapeutic modality," said Dadachova. "Targeting viral antigens with radiolabeled antibodies (or also with specific peptides or aptamers) will allow the extremely precise diagnosis of such cancers and their effective therapy. Furthermore, this approach will make possible 'molecular prevention' of viral cancers, when infected cells will be targeted before they become cancerous."


'/>"/>

Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related medicine news :

1. Harvard Study in Joint Commission Journal: Mortality Rates Lower in Leapfrog Hospitals
2. Emory study of syphilis bacteria yields valuable diagnostic tool
3. New NV Economic Study: Bush Medicare Cuts Undermine State and Local Economic, Jobs Base
4. Benchmarking Study Report on Sales Performance Management
5. UltraShape(R) Commences Pivotal Study for First Non-Invasive Fat Reduction and Body Contouring Device Using Non-Thermal Selective Focused Ultrasound
6. Study pinpoints strategies that protect older adults physical health
7. NIH study concludes next weeks summer chorus camp for seniors improves quality of life
8. Mayo Clinic study reveals rural, unmarried women at higher risk for depression
9. Study aims to improve sex education for deaf pupils
10. Pharmaceutical study: Less hemorrhaging after stroke, but not fewer deaths
11. Carnegie Mellon brain imaging study illustrates how remedial instruction helps poor readers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... VA (PRWEB) , ... March 24, 2017 , ... The ... 2017 Quest Awards . The annual awards, now in their 12th year, are ... peers selects the winners. , In 2016, the awards were retooled to recognize achievements ...
(Date:3/24/2017)... ... March 24, 2017 , ... Texas Physical Therapy Specialists (TexPTS) ... found at 9618 Huebner Road. The clinic is the group’s 7th location in San ... Dr. Ali Higgins, PT, will provide care from the clinic, which opened March 22, ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... and related services to families and business owners across eastern Michigan, is connecting ... regional families struggling with financial difficulties. , The Oxford/Orion FISH Food Pantry works ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... its innovative EcoQube Frame vertical micro-veggies garden on Kickstarter . Surpassing the ... product – with nearly 2,000 consumers (and counting) already backing the campaign. ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... are now offering treatments for sleep apnea and TMJ at their office. TMJ, ... apnea , specifically the obstructive type, is increasingly being treated at dental offices ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Research and Markets has announced the addition of ... report to their offering. ... Pain Management in the U.S.: Consumer ... pain, emphasizing consumer survey analysis, including trends over time. The ... have selected illnesses/conditions strongly associated with physical pain and pain ...
(Date:3/24/2017)... 2017 FinancialBuzz.com News Commentary  ... According to new ... market research, the legal cannabis market is projected to continue ... conflicting signals from the current presidential administration. The report created ... biggest drivers of growth in this industry are the passage ...
(Date:3/24/2017)... March 24, 2017 A ReportsnReports.com report says, ... growing rapidly as the global sales of Adcetris and Kadcyla have ... the antibody drug conjugates market is driven by large number of ... wider therapeutic window offered by ADCs. ... Browse 3 Tables and 94 Figures, 10 Major ...
Breaking Medicine Technology: