Navigation Links
New study shows how spikes in nitrite can have
Date:3/3/2009

(BOSTON) - A new study provides insight into how a short burst in nitrite can exert lasting beneficial effects on the heart, protecting it from stress and assaults such as heart attacks. In this study, just published in Circulation Research, researchers at Boston University School of Medicine have demonstrated for the first time that short elevations in circulating levels of this simple anion are sufficient to have a lasting impact on the heart by modulating its oxidation status and its protein machinery.

Nitrite, an oxidation product of the ubiquitous short-lived cell signaling molecule, nitric oxide (NO), was until recently thought to be biologically inert at the relatively low levels found in the body. Traces of nitrite are present in our diet and significant amounts are continuously produced from nitrate, another oxidation product of NO and a constituent of green, leafy vegetables. The suspicion that high levels of nitrite and nitrate may cause cancer, as well as concerns about their risk to compromise the ability of red blood cells to deliver oxygen to tissues, have led to strict regulations aimed at limiting our exposure to these substances through drinking water and food products.

In the past few years, however, multiple research groups have shown that low concentrations of nitrite exert numerous beneficial effects, ranging from anti-bacterial activities to increases in local blood flow, and that they can somehow protect tissues from damage when oxygen is suddenly cut off and then rapidly restored, as occurs during heart attacks and strokes.

To study the molecular underpinnings of this protective effect of nitrite, the researchers at Boston University School of Medicine used a rat model in which they administered nitrite only once, causing a short spike in circulating levels, as a way to simulate the types of naturally occurring increases in nitrite that follow exercise or consumption of a meal rich in nitrate.


'/>"/>
Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8491
Boston University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... ... , ... Certified Nutrition Businessman Reid Eckert agrees to extend his business relationship ... global sales and communications firm that offers U.S. brands a proven path to world ... Mr. Reid Eckert, as his interpretation of the nutritional needs of the human body ...
(Date:8/29/2015)... ... 30, 2015 , ... On September 30, 2015, the Career and Transfer Center ... accredited Maricopa Community Colleges , will be hosting a Job Expo to provide ... and opportunities. , The Expo has expanded to much more than just a typical ...
(Date:8/29/2015)... , ... August 29, 2015 , ... ... develops, may extend and improve the lives of patients, according to a newly ... Click here to read the full article. , The authors of the ...
(Date:8/29/2015)... ... August 29, 2015 , ... ... chronic obstructive pulmonary disease (including emphysema), or asthma, are at higher risk from ... previous heart attack, heart failure or heart-rhythm problems (arrhythmia or irregular heartbeat) are ...
(Date:8/28/2015)... ... August 28, 2015 , ... Joining a growing number ... recently transitioned management companies to partner with Wound Care Advantage (WCA) to utilize ... center. , Transitioning wound care management providers can be a complex undertaking. ...
Breaking Medicine News(10 mins):Health News:Nutrition Guru Continues Relationship With Renowned Health and Wellness Company 2Health News:Estrella Mountain Community College Expo Offers ‘One-Stop’ for Employers and Students Seeking Internships, Jobs, Careers and Service Learning Opportunities 2Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:Heart Fit Clinic Sounds the Alarm on Forest Fire Smoke and Chronic Heart Disease in Calgary Area 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4
... on finding the mechanism involved in sleep regulation, the ... to be head by Professor Tarja Porkka-Heiskanen, // Institute ... at finding the mechanisms involved in sleep regulation which ... sleep required for proper functioning of brain and will ...
... Health Association (CMHA) has called for better training for policemen ... The Alberta Police had used a Taser on a man, ... opinion that this could have been avoided if specialized training ... ,The victim was a well-dressed man who was apparently going ...
... feces as food for fish growth as increased the widespread fear ... // with the feces to pond farms which may infect wild ... flu virus. Researchers feel that the bird flu outbreak in china ... as feed for fishes in the river Qinghai, which would have ...
... University of Chicago are developing drugs which help in ... by developing mechanisms which helps// in maintaining the lung ... avoid inflammatory cells produced by the cytokines (immune cells) ... increased inflammation and leakage in blood vessels leading to ...
... Lupus erythematosus (lupus) is a disease in which the ... of the skin, joints and internal organs.// A study ... can take oral contraceptives safely without any complications like ... activity, that characterize the disease. ,The study ...
... has collected $2.3 million to be donated to a ... radio programs // . ,The money will be ... Brampton Hospital at Bovaird Drive and Bramalea Road, which ... event, Better Health Radiothon, was organized from Nov 15 ...
Cached Medicine News:
(Date:8/28/2015)... , Aug. 28, 2015 ... addition of the "Investigation Report on China,s Ranibizumab ... Developed by Novartis, ranibizumab was approved by CFDA to ... Currently, only Lucentis, a product of Novartis, is available ... the first self- developed drug for the treatment of ...
(Date:8/28/2015)... 28, 2015  IP Shakti, LLC, today announced that it ... Logo - http://photos.prnewswire.com/prnh/20150827/261551LOGO ... new corporate identity signifies our transformation into a company focused ... platform for patent claim validity." ... proprietary AIA Shield™ platform, the Company commenced a corporate re-branding ...
(Date:8/28/2015)...  Perrigo Company plc ("Perrigo") (NYSE: PRGO ; ... of leading OTC brands from GSK in an all ... a clear demonstration of Perrigo,s unique ability to maximize ... spanning 36 countries.  Perrigo Chairman, President ... are excited to complete this transaction, which clearly demonstrates ...
Breaking Medicine Technology:Investigation Report on China's Ranibizumab Market, 2012-2019 2IP Shakti, LLC Changes Company Name to Prediqtus, LLC 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4
... Now there is a more efficient ... first fully portable battery operated patient ... and surgical teams with a compact ... throughout the entire surgical process. Its ...
... CSZ safely provides effective air warming therapy ... patented design of our WarmAir® FilteredFlo® blankets, ... which supplies gently moving, clean air that ... contaminants to your patient or staff. All ...
Since 1964, in its plants of Sesto Fiorentino, Sbisà produces a wide and qualified range of instruments for ophthalmology and optometry....
Inquire...
Medicine Products: