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New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases
Date:2/24/2011

t always to our benefit," said St. Leger, who is widely recognized for research that employs insects and their pathogens as models for understanding how pathogens in general cause disease, adapt and evolve, and in the application of that understanding to the creation of new methods for safely reducing crop destruction, disease transmission and other damaging insect impacts.

The Malaria Challenge

Infection by malaria-causing parasites results in approximately 240 million cases around the globe annually, and causes more than 850,000 deaths each year, mostly children, according to the World Health Organization. Most of these cases occur in sub-Saharan Africa, but the disease is present in 108 countries in regions around the world. Treating bed nets and indoor walls with insecticides is the main prevention strategy in developing countries, but mosquitoes are slowly becoming resistant to these insecticides, rendering them ineffective.

Malaria prevention strategies can greatly reduce the worldwide burden of this disease, but, as mosquitoes continue to acquire resistance, new and innovative ways to prevent malaria will be needed, experts say.

One such new strategy is killing Anopheles mosquitoes by spraying them with the pathogenic fungus M. anisopliae. Previous studies by African, Dutch and British scientists have found that this method nearly eliminates disease transmission but only when mosquitoes are sprayed soon after being infected by the malaria parasite. The difficulties with this strategy are that it requires high coverage with fungal biopesticides to ensure early infection, and is not sustainable in the long term. If spraying mosquitoes with M. anisopliae kills them before they have a chance to reproduce and pass on their susceptibility, mosquitoes that are resistant to the fungus will soon become predominant and the spray will no longer be effective.

The approach developed by St. Leger and his colleagues avoid t
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Contact: Lee Tune
ltune@umd.edu
301-405-4679
University of Maryland
Source:Eurekalert

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