Navigation Links
New study sheds light on role of genetics in recovering from eating disorders
Date:7/26/2011

A substantial number of people with eating disorders, such as anorexia nervosa have a chronic course. They are severely underweight and have a high likelihood of dying from malnutrition. No treatment has been found that helps people who are chronically ill. Now, a new study sheds light on the reason that some people have poor outcome.

An international team of scientists, led by researchers at the University of California, San Diego (UCSD) School of Medicine and the Scripps Translational Science Institute (STSI) in La Jolla, CA, has identified possible genetic variations that could influence a patient's recovery from an eating disorder such as anorexia or bulimia. Their findings, reported online in the journal Neuropsychopharmcology, may provide new insights into development of effective interventions for the most treatment-resistant patients with these disorders.

"This study sheds light on important 'SNPs' or genetic variations within an individual's DNA, associated with long-term, chronic eating disorders," said Walter H. Kaye, MD, professor of psychiatry and director of UCSD's Eating Disorder Treatment and Research Program, who was senior author with Nicholas J. Schork, PhD, director of bioinformatics and biostatistics at STSI and professor at The Scripps Research Institute. "These variations suggest genetic predictors for patients who may be particularly susceptible to eating disorders and whose illnesses are most difficult to treat effectively."

Kaye said such genetic traits are also linked to individuals with higher anxiety and higher concern over mistakes traits associated with anorexia and bulimia.

Researchers from the Price Foundation Collaborative Study were responsible for the study's data collection, while scientists at STSI and UCSD led the design of the study and the analysis of its results.

According to the study's lead author, Cinnamon Bloss, PhD, assistant professor at STSI, the findings could eventually help pave the way toward a more individualized approach to treating patients with eating disorders. "Anorexia and bulimia likely stem from many different causes, such as culture, family, life changes and personality traits," said Bloss. "But we know biology and genetics are highly relevant in terms of cause and can also play a role in how people respond to treatment. Understanding the genetics behind these conditions is important, because it could eventually help us tailor treatment based on the person's genetic makeup, with the goal of more personalized and effective treatments."

Anorexia and bulimia are serious and complex psychiatric disorders. Anorexia nervosa is characterized by an inability to maintain normal body weight and a relentless pursuit of thinness; bulimia is characterized by recurrent episodes of binge eating. In recent studies, researchers including Kaye have theorized that anorexia and bulimia likely share some risk factors, and that patients may be genetically predetermined to possess personality traits and temperaments that make them susceptible to the eating disorders.

"Individuals with anorexia in particular are often resistant to treatment and lack awareness of the medical consequences of their behavior, which can result in chronic, protracted illness and even death," said Kaye. "The question for us became, 'Are there prognostic factors that might help clinicians identify good versus poor outcomes for treatments including medication or psychotherapies?'"

The research team studied a total of 1,878 women in the large-scale candidate gene association study, which was designed based on hypotheses regarding the genes, pathways and biological systems involved in susceptibility to eating disorders. Most were individuals with a lifetime diagnosis of either anorexia or both anorexia and bulimia, who also exhibited lower body mass index, higher anxiety and higher concern over mistakes than control subjects.

The scientists then identified the top 25 most statistically significant SNPs (single-nucleotide polymorphisms), after evaluating a total of 5,151 SNPs in about 350 genes. According to Bloss, 10 of the 25 most strongly associated "haplotypes" (combinations of alleles for different genes that are located closely together on the same chromosome and that tend to be inherited together) involved SNPs in GABA genes. An intronic SNP on chromosome 4 of the gene GABRGI showed the strongest correlation to chronic symptoms. "The study suggests genes that may pre-dispose individuals to a chronic course of an eating disorder," Bloss said, adding that additional studies are needed to confirm such associations.


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Afghan Medical Staff Face Ongoing Security Threats: Study
2. Lymph Node Test Doesnt Improve Breast Cancer Care, Study Finds
3. Study Finds Savings From Medicares Drug Plan Extend Beyond Cost of Meds
4. INFORMS study: OR models of hepatitis B prove decisive in treating millions in US, China
5. Worrying can impact interpersonal relationships, study finds
6. Returning vets alcohol abuse addressed in virtual reality study
7. Blood Test May Better Predict Diabetics Heart Risk: Study
8. Increased risk of Parkinsons disease in methamphetamine users, CAMH study finds
9. Human Brains Wired to Empathize, Study Finds
10. Antibiotics Beat Cranberries at Fighting Urinary Tract Infections in Study
11. Study finds important risk factors for death/transplantation in children with heart muscle disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
Breaking Medicine Technology: