Navigation Links
New study reveals how tumors remodel their surroundings to grow
Date:7/3/2014

e tumor, because tumor-suppressive activities would be inactivated. It also may explain why therapies aimed at blocking mTOR are showing limited clinical efficacy," added Diaz-Meco.

Unveiling the mechanism of p62

The initial hint that p62 in the stroma influences tumor growth came by analyzing more than 200 human prostate tumors with Gleason scores ranging from 2 to 10. Gleason scores are a numerical assignment given to prostate tumors based on pathology, with the highest scores (10 maximum) indicating that the cancer is very likely to spread. The research team found that p62 levels in the stroma were significantly lower in samples with the highest Gleason scores, suggesting a protective role for p62.

To understand how p62 works, the research team introduced prostate cancer cells and monitored tumor formation in normal mice, and mice genetically engineered to lack p62. The mice without p62, called p62 knockout (KO) mice, had larger prostate tumors compared to normal mice, supporting the notion that the absence of p62 in an organism promotes cancer growth.

The researchers went on to show that p62 KO mice had increased levels of IL-6, a pro-inflammatory cytokine (a signaling molecule) that enhances tumor cell proliferation and inhibits cell death. And, the genetic events that linked p62 depletion to increased levels of IL-6 in mice were mirrored in humans.

"Our observations support a more comprehensive approach to treating cancer, one that is based on our understanding of the communications between a tumor and its environment," added Moscat. "Conceivably, treatments that inhibit tumor-promoting inflammatory signals combined with tumor-specific targets may improve cancer outcomes."


'/>"/>

Contact: Susan Gammon
sgammon@sanfordburnham.org
858-795-5012
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... real-time monitoring and analysis of pet vital signs and activity, today announced its ... one of the most popular and widely-adopted veterinary hospital Practice Management Software packages ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... Royal River ... new study that followed men and women for 19 years and found that, among ... did not take multivitamins. , The report is part of the September 2015 issue ...
(Date:9/1/2015)... ... ... Two of Washington D.C.’s most respected chefs are using their global expertise ... named “the next big thing” in the culinary world by Elle Spain, award-winning culinary ... food and reclaiming culinary traditions on the brink of extinction. According to Amy and ...
(Date:9/1/2015)... ... 2015 , ... METTLER TOLEDO is pleased to announce that ... Kit, EasySampler data is automatically transferred to, and reported with, the referring chemical ... , EasySampler fully automates the sampling process including sampling capture, quench ...
(Date:9/1/2015)... ... ... Ogawa’s new massage chairs tout innovative functionality that change the way robotic ... With the goal of bringing wellness to the world, Ogawa introduces their new line ... in its name, the Ogawa Refresh aims to “refresh” and rejuvenate the ...
Breaking Medicine News(10 mins):Health News:Petpace-Cornerstone Integration Lowers Overhead, Raises Data Visibility for Veterinary Practices 2Health News:New Study Finds Multivitamins Extend Life After Stroke, Retailer Reports 2Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 2Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 4Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 2Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 3Health News:Ogawa World USA Releases New Massage Chairs to the US 2Health News:Ogawa World USA Releases New Massage Chairs to the US 3
... guide from Cleveland Clinic,s Department of Orthopaedic Surgery, available for download as ... ... Cleveland, OH (PRWEB) December 8, 2008 -- In 2008, 240,000 people in ... surgery is not inevitable. A new guide from Cleveland Clinic includes ...
... executives with reassurance their stress-related symptoms are treatable. , ... ... elite group of over 300 CEOs and businesspeople at the Warwick ... Texas physician, Dr. Mark Anderson said with a smile, "you,re ...
... Week runs Dec. 8 - 14 , ... of flu vaccine available, the Pennsylvania Department of Health today teamed ... fans attending the Hershey Bears-Norfolk game at the Giant Center. , ... down with the flu every year, resulting in 8,400 hospitalizations and ...
... Dec. 7 Contract negotiations between,the Ohio Nurses Association ... broke down after the 6th session of,negotiations on Friday, ... to,reach an agreement. , ... change to health,insurance premiums. University Hospitals Geneva has indicated ...
... Inc., announced today that RSI has completed moving its radiology services operations ... N.E., Ste. 200, Atlanta, GA 30307 , ... Atlants, GA (PRWEB) ... announced today that RSI has completed moving its radiology services operations to ...
... Greg Grunberg -- film and television actor,and star of the ... his,12-year-old son, Jake, who has been living with epilepsy, a ... Advocates,from around the country at the L.I.V.E. event in Seattle, ... the community of people living with,epilepsy in Seattle. , ...
Cached Medicine News:Health News:Cleveland Clinic Issues New Guide for Chronic Hip Pain 2Health News:Cleveland Clinic Issues New Guide for Chronic Hip Pain 3Health News:Top Executives Tap Top Docs for Recession-Proof Relief 2Health News:PA Department of Health Kicks Off National Influenza Immunization Week With Free Flu Shots at Hershey Bears Game 2Health News:University Hospitals Geneva Medical Center Registered Nurses to Strike on December 10 if Contract Agreement Cannot Be Reached 2Health News:RSI Expands into New State-of-the-Art Facility 2
(Date:9/1/2015)... 1, 2015 - ... R egistry data presented at ESC ... on the evolution of manag ing AF ... -   The first-ever two-year outcomes from the Global ... 2015 expose that all-cause death was the most frequent major event in more ...
(Date:9/1/2015)... Norway , September 1, 2015 ... biopharmaceutical company, today announces that it has appointed ... as Non-Executive Directors to its Board of Directors, effective ... 30 years of experience in pharma and biotech and ... Genzyme, a Sanofi company. Previously her role was Vice ...
(Date:8/31/2015)... The Indiana Medical Device Manufacturers Council and ... Sciences Policy Forum to state legislators. The new policy ... Diagnostics in Indianapolis and featured ... Ellspermann and State Sen. Brandt Hershman . ... new Learning & Development Center, which is under construction ...
Breaking Medicine Technology:Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 3Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 4Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 5Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 6Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 7Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 8Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 9BerGenBio Appoints Non-Executive Directors 2Indiana Lt. Gov. Sue Ellspermann and State Sen. Brandt Hershman Kick Off New Life Sciences Policy Series 2Indiana Lt. Gov. Sue Ellspermann and State Sen. Brandt Hershman Kick Off New Life Sciences Policy Series 3
... NEW YORK, Jan. 4, 2011 Reportlinker.com announces that a ... Cosmetic Surgery Products http://www.reportlinker.com/p060973/Cosmetic-Surgery-Products.html ... through 2014 Demand for products used in ... to $2.8 billion in 2014, when 16.1 million cosmetic procedures ...
... Jan. 3, 2011 Dynatronics Corporation (Nasdaq: ... of an agreement with Premier Purchasing Partners, L.P., the ... contracted supplier of physical therapy products and exercise equipment ... alternate market facilities.   Premier, Inc. is ...
Cached Medicine Technology:Reportlinker Adds Cosmetic Surgery Products 2Reportlinker Adds Cosmetic Surgery Products 3Dynatronics Named Contract Supplier to Premier, Inc. 2
... 1000 Power Instrument System is a ... versatility and convenience with modular and ... without hand throttle, for use with ... pedal. Accepts all 1000 and 2000 ...
... The Brasseler USA™ 2002 Battery Charger is manufactured ... The 2002 Battery Charger can charge up to ... minutes. The 2002 Charger is designed to operate ... there is a malfunction in the operation of ...
... diamond shaped teeth set the blade on a straight ... are very sharp, and the cut starts true, dancing ... with minimal force due to the sharp, smooth ground, ... , ,The troughs between the teeth provide ...
The High Speed Drill handpiece is a well-balanced, high performance drill that provides high speed for,bone sculpting, along with power for difficult osteotomies. Must be used with the 6401-000 foot ...
Medicine Products: