Navigation Links
New study resolves the mysterious origin of Merkel cells
Date:9/28/2009

A new study resolves a 130-year-old mystery over the developmental origin of specialized skin cells involved in touch sensation. The findings will appear in the October 5, 2009 issue of the Journal of Cell Biology (online September 28).

First described in 1875, Merkel cells are neuroendocrine cells that reside in the vertebrate epidermis, passing mechanical stimuli on to sensory neurons. In mice, they are mainly found in the paws and around the whiskers but, because they express proteins characteristic of both epithelial and neuronal cells, scientists have long debated whether Merkel cells develop from the epidermis or neural crest.

Van Keymeulen et al. traced the lineage of Merkel cells by fluorescently labeling cells derived from either epidermal or neural crest progenitors. This revealed that Merkel cells originally emerge from the embryonic epidermis. In addition, epidermal stem cells in adult mouse skin replenish the Merkel cell population as they slowly die off over time. The researchers also found that a transcription factor called Atoh1 is required for epidermal progenitors to differentiate into Merkel cellsmice lacking Atoh1 in their skin failed to develop any of the mechanotransducing cells.

Atoh1 acts as a tumor suppressor to prevent an aggressive skin cancer called Merkel cell carcinoma, says senior author Cdric Blanpain. His team now wants to investigate the precise function of the transcription factor in Merkel cell differentiation, as well as the signaling pathways that regulate the process.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New study resolves the mysterious origin of Merkel cells
(Date:5/5/2016)... ... May 05, 2016 , ... Vitenas Cosmetic Surgery has been ... presented by the American Institute of Architects and the Academy of Architecture for Health. ... Perkins+Will and Harrell Architects, opened to patients in October of 2014. ...
(Date:5/5/2016)... ... 05, 2016 , ... Dr. Benjamin Stong of Kalos Facial Plastic Surgery, LLC ... Stong is double board certified and the only facial plastic surgeon in Atlanta to ... Non-surgical therapies such as stem cells can be used to provide stabilization to hair ...
(Date:5/5/2016)... ... May 05, 2016 , ... In honor of National Nurses Week 2016, ... the United States to thank a nurse who's made a difference in their life. ... the American Red Cross of San Diego/Imperial Counties (up to $10,000) every time someone ...
(Date:5/5/2016)... Boston, MA (PRWEB) , ... May 05, 2016 , ... ... stress becomes a constant presence, it can weaken the immune system and increase inflammation, ... Ami B. Bhatt, director of the adult congenital heart disease program at Harvard-affiliated Massachusetts ...
(Date:5/5/2016)... PLAINSBORO, N.J. (PRWEB) , ... May 05, 2016 , ... ... on patients with cancer, today announced a new collaboration with Imerman Angels ... of cancer anywhere in the world. , “Imerman Angels provides an emotional lifeline to ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016 Research ... PET Imaging in Top 5 EU Markets"  report to their ... This report provides information on the current Positron Emission Tomography ... European Markets (T5 EU), which includes France ... , Spain and the ...
(Date:5/4/2016)...  Compass Diversified Holdings (NYSE: CODI ) ... leading middle market businesses, announced today its consolidated operating ... First Quarter 2016 Highlights , Generated ... "Cash Flow") of $13.6 million for the first quarter ... million for the first quarter of 2016; , ...
(Date:5/4/2016)... Yissum Research Development Company of the ... had signed an exclusive world-wide licensing and research agreement ... degradation and immunomodulatory drugs for cancer and immune dysfunction, ... first-in-class therapy for hematologic and solid malignancies. Financial terms ... novel technology was developed by Yinon Ben-Neriah , ...
Breaking Medicine Technology: