Navigation Links
New study of targeted therapies for breast cancer -- model for global clinical trials
Date:2/28/2008

Two targeted medications designed to treat an aggressive form of breast cancer are being tested in a new study involving 8,000 participants in 50 countries across six continents -- a clinical trial that investigators hope will provide a new model for global cancer research. This trial, dubbed ALTTO (Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization study), will be one of the first global initiatives in which two large, academic breast cancer research networks covering different parts of the world have jointly developed a study in which all care and data collection are standardized, regardless of where patients are treated. The networks are The Breast Cancer Intergroup of North America (TBCI), based in the United States, and the Breast International Group (BIG) in Brussels, Belgium. TBCI consists of six National Cancer Institute (NCI)-funded clinical trials cooperative groups. NCI is part of the National Institutes of Health.

ALTTO is designed to answer the most pressing questions regarding use of two widely used cancer agents: whether one agent is more effective, which agent is safer for patients, and what benefit will be derived by taking the drugs separately, in tandem order, or together" The trial is a randomized, Phase III study, which is considered a gold standard method for proving drug effectiveness.

The two agents tested in ALTTO are drugs designed to treat HER2-positive tumors, which is a particularly aggressive form of cancer that affects approximately 20 percent to 25 percent of breast cancer patients. Both agents, trastuzumab (Herceptin) and lapatinib (Tykerb), have already been approved by the U.S. Food and Drug Administration for use for treatment of HER2-positive breast cancer. ALTTO will provide the first head-to-head comparison of trastuzumab and lapatinib in the earliest, most treatable stages of cancer. It will also be one of the first large-scale studies to evaluate lapatinibs effectiveness in treating early breast
'/>"/>

Contact: NCI Press Officers
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Study examines how men and women view marital and parental time pressures
2. Low-intensity exercise reduces fatigue symptoms by 65 percent, study finds
3. Leicester scientist announces unexpected and exciting advance in study of cancer type
4. UCLA launches network to study health care disparities affecting minorities
5. This is your brain on jazz: researchers use MRI to study spontaneity, creativity
6. U of Minnesota study finds thalidomide shows promise for treatment of recurrent ovarian cancer
7. Only Severely Depressed Benefit From Antidepressants: Study
8. Joslin study finds restricting insulin doses increases mortality risk
9. Study Finds Variations in Doses of Radiation Therapy
10. Study looks at new bladder cancer therapy for patients unresponsive to standard treatment
11. LSU researchers study coastal community bounce back
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... 2014 Recently, Skmen.com, an outstanding company in ... bohemian dresses . In addition to this, the company ... Now, all of them are available at low rates, up ... product design and quality. Its beautiful bohemian outfits are available ... many others. Owing to its top quality clothes, reasonable prices ...
(Date:8/19/2014)... 19, 2014 Kars4Kids , a ... announced today its partnership with New York State Senator ... in the Bronx. The giveaway will take place in ... Crotona Park on August 22. , “With a ... believe properly preparing children for school with the necessary ...
(Date:8/19/2014)... has recently compared many popular hosting suppliers and announced ... recommended companies for webmasters who want to buy high ... an affordable price. , Both GoDaddy and iPage ... the lowest upfront costs (including some Joomla hosting products ... of options. , GoDaddy is a famous supplier ...
(Date:8/19/2014)... 19, 2014 Grande Naturals, LLC ... winner of the 2014 Independent Cosmetics Manufacturers & ... first place position in “Product Innovation; Product Color ... which also includes a lash enhancement serum, GrandeLINER™. ... lash-boosting technology. , This all-new eyeliner ...
(Date:8/19/2014)... HealthDay Reporter TUESDAY, ... be added to the list of possible harms related ... treat behavioral symptoms of dementia in older adults, a ... olanzapine (Zyprexa) are approved by the U.S. Food and ... serious mental disorders. They are also frequently used "off-label" ...
Breaking Medicine News(10 mins):Health News:2014 Bohemian Dresses Now for Sale at Skmen.com 2Health News:Backpack Giveaway Kars4Kids Partners with New York State Senator Gustavo Rivera to Prepare Bronx Students for New School Year 2Health News:Top10BestSEOHosting.com: Cheap Joomla Hosting Reviews Unveiled 2Health News:GrandeLINER™ Wins Independent Cosmetics Manufacturers & Distributors Award 2Health News:GrandeLINER™ Wins Independent Cosmetics Manufacturers & Distributors Award 3Health News:Certain Antipsychotic Meds Tied to Kidney Problems in Elderly 2Health News:Certain Antipsychotic Meds Tied to Kidney Problems in Elderly 3
... June 17 NeoMend, Inc. today announced,that its ... from the U.S. Food and Drug Administration,s (FDA) ... panel,s recommendation will be considered by the FDA ... (PMA) for ProGEL. The,panel,s recommendation for FDA approval ...
... BOSTON--Patients diagnosed with colon cancer who had abundant vitamin D ... follow-up period than those who were deficient in the vitamin, ... Institute. , The findings of the study -- the first ... patients -- merit further research, but it is too early ...
... Access to Personal ... Enrolls Nearly 1,000 Police Officers in MedeFile System During National ... ... Board: MDFI), a company specializing in,portable electronic medical records management solutions, today announced,that ...
... -- Research findings and innovative approaches offer the promise ... adults living with type 1 diabetes, according to researchers ... Forum in Washington D.C. , Type 1 diabetes is ... insulin-producing beta cells in the pancreas. It renders ...
... June 18 A CI head once noted that,"Competitive ... but the only,time you realize you need it is ... marketing space, most companies need competitive,intelligence to effectively deal ... insights are lacking that people begin to realize how,critical ...
... 18 Sunrise Senior Living,Inc. (NYSE: SRZ ), ... will present at the 2008 Jefferies 2nd Annual,Healthcare Conference ... 1:30 p.m.,Eastern Time. Sunrise will Web cast the presentation ... http://www.sunriseseniorliving.com ). A replay of the Web cast will ...
Cached Medicine News:Health News:NeoMend Receives FDA Panel's Recommendation for Approval of ProGEL(TM) Surgical Sealant 2Health News:Study links vitamin D to colon cancer survival 2Health News:MedeFile International Teams with Newark Fraternal Order of Police 2Health News:MedeFile International Teams with Newark Fraternal Order of Police 3Health News:MedeFile International Teams with Newark Fraternal Order of Police 4Health News:Science, hope for adults with type 1 diabetes focus of JDRF's Annual Global Diabetes Research Forum 2Health News:Science, hope for adults with type 1 diabetes focus of JDRF's Annual Global Diabetes Research Forum 3Health News:Build and Maintain an Effective Competitive Intelligence Group 2
(Date:8/19/2014)... Aug. 19, 2014 Minimally Invasive Devices Inc. ... device company, announced today that Mitsubishi Corporation has formally ... visualization system in Japan . MID ... Japan in the second half ... exclusive distributor for Karl Storz GMBH & Co. (endoscopic ...
(Date:8/19/2014)... , Aug. 19, 2014  Tokyo-based Atonarp ... A funding round led by Walden Riverwood Ventures ... the development of Atonarp,s Smart Spectrometer technology platform, ... The company has targeted the oil & gas ... "We are excited to partner with Atonarp ...
(Date:8/19/2014)...  Boehringer Ingelheim today announced that the U.S. ... the New Drug Application (NDA) for the fixed-dose ... the Respimat ® inhaler for the proposed ... obstruction in patients with chronic obstructive pulmonary disease ... olodaterol FDC will not be indicated to treat ...
Breaking Medicine Technology:Minimally Invasive Devices and Mitsubishi Medical Japan Forge Exclusive Distribution Agreement 2Atonarp Inc. Raises $8M Series A Round Led by Walden Riverwood Ventures 2Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 2Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 3Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 4Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 5Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 6Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 7Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD 8
... Based on decades of experience, the SSD-1000 ... ultrasound system. It uses our advanced technologies ... experience. Using the same technology as our ... imaging capabilities in a compact and mobile ...
... Using pulsed radiofrequncy current, ... system quickly heats and ablates ... it in minimal time., RF ... in open surgery, percutaneously, or ...
... a biologically based adhesive supplied as ... consisting of a liquid substrate and ... internal bleeding. When combined ... to a prepared wound and tenaciously ...
... (Human) achieves a secure clot, targeted to ... for hemostasis is needed, when control of ... ligature, and cautery, is ineffective or impractical., ... formulation of human Biologically Active Component (BAC) ...
Medicine Products: