Navigation Links
New study finds that add-on therapy improves depressive symptoms in bipolar disorder
Date:9/2/2008

Philadelphia, PA, September 2, 2008 Lingering depression is a serious and common problem in bipolar disorder, and does not resolve well with existing treatments. Because individuals with both depression and bipolar disorder experience a glutathione deficiency, an antioxidant that protects cells from toxins, researchers in a new study scheduled for publication in the September 15th issue of Biological Psychiatry sought to evaluate whether N-acetyl cysteine (NAC), an over-the-counter supplement that increases brain glutathione, might help alleviate depressive symptoms.

Dr. Michael Berk and colleagues, in a randomized, double-blind, placebo-controlled trial, evaluated the mood symptoms of individuals with bipolar disorder, half of whom received placebo and half of whom received NAC, as an add-on therapy to their usual treatment. Over the 24 weeks of the study, NAC was well tolerated, and induced a marked and significant improvement in depressive symptoms. Ashley Bush, M.D., Ph.D., the article's corresponding author, further explains: "Glutathione is the brain's primary antioxidant defense, and there is evidence of increased oxidative stress in bipolar disorder. Therefore, we studied the potential benefit of NAC treatment in bipolar disorder and found that it impressively remedied residual depressive symptoms."

John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, comments: "The preliminary evidence of efficacy of NAC is very interesting. This study might suggest a number of novel approaches to treating depression. In subsequent efforts to replicate this preliminary finding, it will be important to determine how much NAC reaches the brain after oral administration." As noted by both the authors and Dr. Krystal, additional studies will be necessary to further evaluate and replicate these findings. However, as Dr. Berk observes, "Br
'/>"/>

Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... ... August 27, 2015 , ... According to an ... Heart Association have released new guidelines to educate doctors and patients on the best ... these particular guidelines came in 2007, so the new version is taking into account ...
(Date:8/27/2015)... ... August 27, 2015 , ... On May 30th, 2015, at the ... as sponsor of the “Music With A Mission” benefit concert. For the past two ... programs in the underfunded school districts of Mendon and neighboring town, Quincy, IL. Organized ...
(Date:8/27/2015)... , ... August 27, 2015 , ... ... today that its Krames Patient Education content is ICD-10 ready and available to ... for the new ICD-10 code sets, which are more targeted and return a ...
(Date:8/27/2015)... ... ... Banc Intranets recently entered into a strategic partnership with Bank ... Tenn.-based firms to work synergistically to promote similar products to the same market. ... in the financial, commercial and services sectors. The software, which is sold by a ...
(Date:8/27/2015)... ... 27, 2015 , ... Susan Harris and the team at LifeStream ... to pre- and post-menopause, chemotherapy, and child birth. , The MonaLisa Touch ... to the vaginal tissue, revitalizing cells so they make more collagen, an essential component ...
Breaking Medicine News(10 mins):Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 2Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 3Health News:Best Drug Rehabilitation Interviews Madd Hoss Jackson at the 2015 "Music With A Mission" Benefit Concert 2Health News:StayWell announces all health content is ICD-10 ready 2Health News:StayWell announces all health content is ICD-10 ready 3Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 2Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 3Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 4Health News:LifeStream Health Centre & MedSpa Announces New Treatment for Vaginal Discomfort 2Health News:LifeStream Health Centre & MedSpa Announces New Treatment for Vaginal Discomfort 3
... MDTH ) announced today that James E. Harris has ... become the Chief,Financial Officer for Charlotte, N.C. based Coca-Cola ... years, affiliation having,served on its Board of Directors and ... until near the end of January 2008, has been,with ...
... Allscripts, the leading,provider of clinical software, connectivity ... healthcare, today announced that the company,s,TouchWorks(TM) Electronic ... 1 product,in its market segment by the ... http://www.newscom.com/cgi-bin/prnh/20061005/ALLSCRIPTSLOGO-b ), TouchWorks earned the "Best ...
... Agency Adds 23 Clients in US, Europe and ... America,s largest and,fastest growing pay-for-placement public relations agency, ... businesses from South America to Asia.,The two-year old ... in a range of industries including financial services,healthcare, ...
... Officials, Legal Experts to Discuss Latest Criminal,Cases, Decrees and ... WASHINGTON, Dec. 20 In the last year,mainstream ... than $1.9,billion in fines, civil settlements and penalties. Top ... they did not,participate in or know about the crimes., ...
... ... heart disease patients, DETROIT, Dec. 20 Studies ... depression than those without heart,disease. The link between these two diseases ... heart patients is under-recognized and,even when diagnosed, under-treated., That,s why ...
... New Site Leadership Team at Cambridge Facility -, ... of its role as the global biologics unit ... D. Skibo has joined the company,as senior vice ... of the company, has been promoted to vice ...
Cached Medicine News:Health News:James E. Harris to Become Chief Financial Officer of Coca-Cola Bottling Co. Consolidated 2Health News:Allscripts Electronic Health Record Ranked No. 1 by Physician Groups in KLAS Year-End Report 2Health News:Allscripts Electronic Health Record Ranked No. 1 by Physician Groups in KLAS Year-End Report 3Health News:PayPerClip Grows 370% in 2007 2Health News:Food and Drug Law Institute Sponsors Major Enforcement Conference 2Health News:Blue Cross Blue Shield of Michigan Foundation Funds Study Exploring Link between Heart Disease and Depression 2Health News:MedImmune Expands Scientific and Engineering Leadership 2Health News:MedImmune Expands Scientific and Engineering Leadership 3Health News:MedImmune Expands Scientific and Engineering Leadership 4Health News:MedImmune Expands Scientific and Engineering Leadership 5
(Date:8/27/2015)... August 27, 2015 According to a new ... Toilet, Seating, Universal, Standing, Bariatric ), Material (Nylon, Padded, Canvas), Usage ... 2020", published by MarketsandMarkets, the Medical Lifting Sling Market is poised ... in 2015, at a CAGR of 11.4 % from 2015 to ... ma rket data T ables and 65 ...
(Date:8/27/2015)... Ala. , Aug. 27, 2015 /PRNewswire/ ... Outpatient Pharmacy Provider (IOPP™) is expanding its ... of a medication-focused transition of care program ... named "RxCare Management," provides hospitals with technology ... hospital performance measures that have been mandated ...
(Date:8/27/2015)... Aug. 27, 2015 NorthStar Anesthesia , one ... it has been selected by Mercy, based in ... four of their hospitals:  Mercy St. Vincent  Medical Center and ... , Mercy St. Charles  Hospital in Oregon ... Tiffin . "As we looked to ...
Breaking Medicine Technology:Medical Lifting Sling Market Worth USD 706.0 Million by 2020 2Medical Lifting Sling Market Worth USD 706.0 Million by 2020 3Medical Lifting Sling Market Worth USD 706.0 Million by 2020 4Rx Care Management by Proxsys Rx - Transition of Care Technology Helps Prevent Hospital Medication Errors 2Four Mercy Hospitals in Northwest Ohio Select NorthStar Anesthesia 2
... 2011 The ophthalmic therapeutics company Xcovery Vision announced ... and Dr. Ken Mandell, President and COO, will be ... Ophthalmology (ARVO) Annual Meeting in Fort Lauderdale Florida, May ... Serial Entrepreneur recounts his repeated success as founder ...
... Pharmacal Company, LLC has become aware of a broad ... Pads, manufactured by H&P Industries Inc. and marketed under ... Prep Pads were included in the Atwater Carey First ... interest of consumer safety, Wisconsin Pharmacal wants to ensure ...
Cached Medicine Technology:Xcovery Vision Founders to Speak at ARVO 2011 2Important Information for Atwater Carey First Aid Kit Consumers Regarding Triad Group's Povidone Iodine Prep Pads 2
... instrument is a self-contained, compact, easy-to-use, bedside ... reagents, the Ichor system provides a hematology ... count plus platelet aggregation within five minutes. ... blood sample is added to both an ...
... Immedia PT System is an in vitro ... (PT) results, expressed in seconds and INR ... blood. It is intended for use by ... care to monitor patients who are on ...
... family, which includes the world's smallest ... most advanced pacemaker technology available, including ... first and only U.S. commercially approved ... (AF). The AF Suppression algorithm in ...
... IntelliVue Information Center combines the ... station with sophisticated clinical analysis tools. ... with Philips innovative portal technology so ... side by side with digital radiology ...
Medicine Products: