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New study finds resistant organisms at core of soft contact lens corneal infections
Date:1/28/2008

s, to put it simply, said Dr. Ghannoum.

We recommend that solutions be tested for biofilms produced by more recent clinical isolates, said Dr. Ghannoum. One of the underlying reasons for ReNu with MoistureLoc not being effective against the outbreak of keratitis is that the solution is not effective against biofilms and the organisms contained in biofilms.

The researchers tested six kinds of contact lenses made by three different manufacturers and two lens care solutions (Bausch & Lombs MoistureLoc and MultiPlus) against three fungal strains (two recent clinical strains and the one from the 1970s) of Fusarium and one strain of C. albicans.

Since biofilm contamination of contact lens cases is a common finding, and ReNu with MoistureLoc is ineffective against fungal biofilm, the industry must ensure that their multipurpose solutions are effective against biofilms, said Dr. Ghannoum. In the meantime, extreme caution must be taken to ensure the contact lens care case is not contaminated with biofilm.

Dr. Ghannoum recommends that soft contact lens wearers use only fresh lens care solution, not add fresh solution to old solution, a phenomenon known as topping off, and use solution by expiration dates written on the package. He also recommends a rub and rinse method, regardless of which cleaning or disinfecting solution used (which also is recommended by the Centers for Disease Control and Prevention). An additional preventative measure to prohibit the development of biofilms is to ensure that the bottle caps and tips of multipurpose solutions are clean.


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Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals of Cleveland
Source:Eurekalert

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