Navigation Links
New study finds resistant organisms at core of soft contact lens corneal infections
Date:1/28/2008

In 2006, Bausch & Lomb withdrew its ReNu with MoistureLoc contact lens solution because a high proportion of corneal infections were associated with it. Now in a new study from University Hospitals Case Medical Center, researchers show that these infections were fueled and made resistant to treatment by the formation of a highly resistant structure of microbial cells held together with a glue-like matrix material. Scientists call this conglomeration of cells biofilms.

Once they live in that type of state, the cells become resistant to lens solutions and immune to the bodys own defense system, said Mahmoud A. Ghannoum, Ph.D., director of the Center for Medical Mycology at University Hospitals Case Medical Center and senior investigator of the study which appears in the January 2008 issue of the journal Antimicrobial Agents and Chemotherapy. This study should alert contact lens wearers to the importance of proper care for contact lenses to protect against potentially virulent eye infections, he said.

Biofilms are a constellation of resistant organisms, Dr. Ghannoum said. They were suspected with the spate of infections in 2005-2006, but until this study, there were no data to prove this. This is the first in-vitro model for cornea keratitis infections caused by the fungus Fusarium, which was one of the main culprits in the ReNu with Moisture Loc cases, and another fungus called Candida albicans.

The researchers also discovered that the strain of fungus (ATCC 36031) used for testing the effectiveness of lens care solutions is a strain that does not produce biofilms as the clinical fungal strains do. Lens care solutions currently are tested against an old and rare genotype fungal strain obtained in the 1970s from a patient from Nigeria. The contact lens solutions, therefore, are effective in the laboratory, but fail when faced with strains in real-world situations. The multipurpose contact lens solutions cannot kill these germs, to put it simply, said Dr. Ghannoum.

We recommend that solutions be tested for biofilms produced by more recent clinical isolates, said Dr. Ghannoum. One of the underlying reasons for ReNu with MoistureLoc not being effective against the outbreak of keratitis is that the solution is not effective against biofilms and the organisms contained in biofilms.

The researchers tested six kinds of contact lenses made by three different manufacturers and two lens care solutions (Bausch & Lombs MoistureLoc and MultiPlus) against three fungal strains (two recent clinical strains and the one from the 1970s) of Fusarium and one strain of C. albicans.

Since biofilm contamination of contact lens cases is a common finding, and ReNu with MoistureLoc is ineffective against fungal biofilm, the industry must ensure that their multipurpose solutions are effective against biofilms, said Dr. Ghannoum. In the meantime, extreme caution must be taken to ensure the contact lens care case is not contaminated with biofilm.

Dr. Ghannoum recommends that soft contact lens wearers use only fresh lens care solution, not add fresh solution to old solution, a phenomenon known as topping off, and use solution by expiration dates written on the package. He also recommends a rub and rinse method, regardless of which cleaning or disinfecting solution used (which also is recommended by the Centers for Disease Control and Prevention). An additional preventative measure to prohibit the development of biofilms is to ensure that the bottle caps and tips of multipurpose solutions are clean.


'/>"/>

Contact: George Stamatis
george.stamatis@uhhospitals.org
216-844-3667
University Hospitals of Cleveland
Source:Eurekalert

Related medicine news :

1. Feds fund study of drug that may prevent radiation injury
2. Study examines self-expanding plastic stents in the treatment of benign esophageal conditions
3. Amalgam Fillings Dont Affect Childrens Brain Development, Says Study in ADA Journal
4. Amalgam fillings dont affect childrens brain development, says study in ADA Journal
5. Global Health and Business Leaders Announce 36-Month Effort to Expand Malaria Control in Africa; 3.5 Million Lives Could be Saved in Five Years, Study Finds
6. From Research to Practice: Healthfitness, Eastman Chemical Company Case Study Demonstrates Real-World Health Gains and Productivity Savings
7. Study raises questions about diagnosis, medical treatment of ADHD
8. Another Study Links Western Diet to Heart, Health Risks
9. Nerites Receives NIH Grant to Study Novel Treatment for Preventing Dangerous Bacterial Infections on Urinary Stents and Catheters
10. New Kaiser Permanente study fortifies caffeines link to miscarriage
11. Kaiser Permanente study shows link between caffeine and miscarriage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ... 2017 , ... This morning, more than 275 medical doctors, ... for an independent Vaccine Safety Commission. Five of the signers of the letter, ... a press conference at 9:00 AM Friday, March 31 at the National ...
(Date:3/29/2017)... Georgia (PRWEB) , ... March 29, 2017 , ... Full ... Therilus, founder of Pet Protect Law that assists dog owners in creating ... assist new owners in taking the natural next step to protect their new companion. ...
(Date:3/29/2017)... ... 30, 2017 , ... Sports Brand EXOUS Bodygear announced today a special sale ... for the remaining days of March, the price will be only $19.97. The EXOUS ... of just $10 (regular retail price $19.97). , The special promotional prices are to ...
(Date:3/29/2017)... ... 29, 2017 , ... Patients interested in receiving quick and ... Jamie Cameron, with or without a referral. The FASTBRACES system is valued for ... each patient’s case, treatment with the FASTBRACES system could be completed in 120 ...
(Date:3/29/2017)... ... , ... Curio Wellness , a premium medical cannabis brand and trusted ... management team with prominent executives from both inside and outside the cannabis industry. ... Ted Dumbauld , who has more than twenty years of business leadership and investment ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... YORK , March 29, 2017 Global intravenous ... US$ 3 billion by 2021, growing at a CAGR of ... iron prescribed by a doctor to treat anemia or other ... iron level in the body. However, in some cases, oral ... the body and intravenous (IV) iron therapy comes into the ...
(Date:3/29/2017)... -- Research and Markets has announced the addition of the ... Forecast" report to their offering. ... Proton Therapy Market in Italy will ... There are currently three proton therapy centers in Italy ... Italy , the first patients were treated with proton ...
(Date:3/29/2017)... 2017  The Global Health Innovative Technology Fund ... to battle infectious diseases around the globe, today ... could help deliver a range of new innovative ... This latest round of targeted support ... testing a pediatric formulation of a drug considered ...
Breaking Medicine Technology: