Navigation Links
New study finds possible source of beta cell destruction that leads to Type 1 diabetes
Date:2/4/2010

NORFOLK, Va. Doctors at Eastern Virginia Medical School's Strelitz Diabetes Center have been stalking the culprit responsible for Type 1 diabetes. Now, they are one step closer.

Members of a research team at the center, led by Jerry Nadler, MD, professor and chair of internal medicine and director of the center, have been studying the role of the enzyme 12-Lipoxygenase (12-LO) in the development of Type 1 diabetes. They hope that targeting this enzyme will hold the key to a cure.

Dr. Nadler and several research colleagues in the EVMS Department of Internal Medicine, including Kaiwen Ma, PhD, research instructor; Swarup K. Chakrabarti, PhD, research assistant professor; and David A. Taylor-Fishwick, PhD, associate professor, recently published their findings in the February issue of The Journal of Clinical Endocrinology and Metabolism.

Type 1 diabetes is a chronic condition that develops when the pancreas stops generating enough insulin to maintain normal levels of glucose (sugar) in the blood. Insulin moves sugar from the bloodstream to cells so that it can be used to generate energy. In Type 1 diabetes, a person's immune system attacks the insulin-producing beta cells, found only in the pancreas. When the beta cells die, the body no longer can produce enough insulin to regulate blood-glucose levels, and this can lead to serious health complications, even death, without treatment.

It is generally understood that inflammation plays a vital role in beta-cell destruction. But the precise factors are not well known. A protein-based enzyme found in beta cells, 12-LO produces specific lipids that cause inflammation and can lead to the death of beta cells in laboratory models. In fact, EVMS researchers have demonstrated that deleting the gene that produces 12-LO prevents the development of Type 1 diabetes in mice.

The challenge has been to validate that 12-LO and its pro-inflammatory lipid products have a role in h
'/>"/>

Contact: Jina Gaines
gainesjn@evms.edu
757-446-7070
Eastern Virginia Medical School
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 25, 2014 The short film “Color of ... in honor of a true 9/11 hero, Welles Remy Crowther. ... including the 24 hours of Nuremberg International Short Film Festival ... , Actress, screenwriter and director Luciana Lagana plays ... together with her husband, Gregory Graham - Graham ...
(Date:12/25/2014)... FL (PRWEB) December 25, 2014 When head ... find themselves in a frenzy to get rid of it ... But families in Coral Gables now have the solution right ... second salon clinic location, Lice Troopers provides full spectrum head ... the Coral Gable area, including Sunset, Key Biscayne, Brickell, Coconut ...
(Date:12/25/2014)... THURSDAY, Dec. 25, 2014 (HealthDay News) -- Overeating is common ... you eat in moderation, an expert says. "Don,t arrive ... up calories if you know you,ll be attending a party, ... Jill Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount ... better to eat healthy during the day and even to ...
(Date:12/25/2014)... York, New York (PRWEB) December 25, 2014 ... ) continue to move forward in a number of ... District of West Virginia, Bernstein Liebhard LLP reports. According ... Court is scheduled to convene a Joint Status Conference ... at 10:00 a.m. Parties have been directed to submit ...
(Date:12/25/2014)... Each year trauma accounts for approximately ... admissions across the nation (according to the Centers ... National Hospital Ambulatory Medical Care Survey collected data ... 2010. They estimated that there were between 3.5 and ... primary diagnosis of broken bone or fracture. , ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... In the racy television hit show, Sex and the City, ... that "Men who are too good looking are never good ... just one of the many gender stereotypes that audiences were ... about sex and gender and refrained from the gender caricatures ...
... set up in London to bring the Cinderella area of medicine ... million centre of excellence has just begun at Queen Mary, University ... The aim is to fast-track new operations for bowel ... out to hospitals all over the UK. The NCBRSI ...
... Antiviral drugs used to target the herpes virus could be ... new study shows. The University of Manchester scientists have ... is a risk factor for Alzheimer,s when it is present ... risk to the disease. AD is an incurable neurodegenerative ...
... , MONDAY, Oct. 17 (HealthDay News) -- ,Fast ... the same vehicle are among the reasons why thousands of ... according to new research. The findings were to be ... Conference and Exhibition in Boston. According to the AAP, ...
... By Randy Dotinga HealthDay Reporter , MONDAY, ... into fountains of four-letter words? Maybe so, says a new ... profanity-ridden shows and video games. However, the research ... swearing among kids, nor does it explain why non-aggressive cussing ...
... children who live in a home with a swimming pool ... death among toddlers. A study abstract presented Monday, Oct. 17, ... Exhibition in Boston identifies three likely scenarios that precede the ... in an at-home swimming pool. In the study, "Patterns ...
Cached Medicine News:Health News:Women, men and the bedroom 2Health News:New national research center for bowel disease in London will be a UK first 2Health News:New national research center for bowel disease in London will be a UK first 3Health News:New national research center for bowel disease in London will be a UK first 4Health News:Antiviral drugs may slow Alzheimer's progression 2Health News:Too Many Kids Injured in ATV Crashes, Study Finds 2Health News:Profanity on TV Linked to Foul-Mouthed Kids 2Health News:Study identifies scenarios that precede at-home pool drownings of young children 2
(Date:12/22/2014)... Dec. 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), a ... blood purification technology to help fight deadly inflammation ... countries worldwide, today announced the appointment of Dr. ... as its Senior Vice President of Clinical Development, ... Di Russo is an accomplished pediatric ...
(Date:12/22/2014)... , Dec. 22, 2014   TRU-D SmartUVC ... no-touch UV disinfection robot, announced today that the General ... contract through November 2019.   This newly ... engage all levels of government purchasers, including Department of ... well as Homeland Security contacts purchasing solutions for the ...
(Date:12/22/2014)... STOCKHOLM , Dec. 22, 2014 Swedish ... Inc. today announced that the Committee for Medicinal Products ... (EMA) has adopted a positive opinion for the use ... adult men with Peyronie,s disease with a palpable plaque ... the start of therapy. The use of ...
Breaking Medicine Technology:CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6
... SEELZE, Germany, Dec. 3 Honeywell (NYSE: ... Pro-Lab Laboratuar Teknolojileri, which will distribute Honeywell,s Burdick & ... solvents are used extensively by biotechnology and pharmaceutical companies ... annual growth rate of the Turkish pharmaceutical market is ...
... , JERSUSALEM and NEEDHAM, ... ORIDN) today announced that the Bavarian Red Cross has chosen ... use of capnography can help paramedic teams to assess the ... to issues that affect respiratory status such as displaced endotracheal ...
Cached Medicine Technology:Honeywell and Pro-Lab Sign Distribution Agreement for Laboratory Chemicals in Turkey 2Honeywell and Pro-Lab Sign Distribution Agreement for Laboratory Chemicals in Turkey 3Oridion Microstream(R) Technology Chosen by the Bavarian Red Cross for Improved Patient Safety 2Oridion Microstream(R) Technology Chosen by the Bavarian Red Cross for Improved Patient Safety 3Oridion Microstream(R) Technology Chosen by the Bavarian Red Cross for Improved Patient Safety 4
... NCP-1, was designed to maximize patient comfort ... the first ever to feature Vacuum Pump ... augmentation and reduces the "slamming" effect commonly ... treatment platform maintains patients comfort and security ...
... The Arctic Sun 2000 represents a ... The Arctic Sun System rapidly induces mild ... from therapeutic hypothermia or rapidly reduces temperature ... monitors and maintains core body temperature in ...
... Artic Sun 100 monitors and controls patient ... hypothermia associated with surgery, trauma, or other ... response to feedback provided from a patient ... ambient (room air) and 42C (107.6F) to ...
... its professional AED offeringthe G3 Pro. ... ECG color display, provides manual override ... most advanced technology available to provide ... for emergency treatment of sudden cardiac ...
Medicine Products: