Navigation Links
New study finds possible source of beta cell destruction that leads to Type 1 diabetes
Date:2/4/2010

NORFOLK, Va. Doctors at Eastern Virginia Medical School's Strelitz Diabetes Center have been stalking the culprit responsible for Type 1 diabetes. Now, they are one step closer.

Members of a research team at the center, led by Jerry Nadler, MD, professor and chair of internal medicine and director of the center, have been studying the role of the enzyme 12-Lipoxygenase (12-LO) in the development of Type 1 diabetes. They hope that targeting this enzyme will hold the key to a cure.

Dr. Nadler and several research colleagues in the EVMS Department of Internal Medicine, including Kaiwen Ma, PhD, research instructor; Swarup K. Chakrabarti, PhD, research assistant professor; and David A. Taylor-Fishwick, PhD, associate professor, recently published their findings in the February issue of The Journal of Clinical Endocrinology and Metabolism.

Type 1 diabetes is a chronic condition that develops when the pancreas stops generating enough insulin to maintain normal levels of glucose (sugar) in the blood. Insulin moves sugar from the bloodstream to cells so that it can be used to generate energy. In Type 1 diabetes, a person's immune system attacks the insulin-producing beta cells, found only in the pancreas. When the beta cells die, the body no longer can produce enough insulin to regulate blood-glucose levels, and this can lead to serious health complications, even death, without treatment.

It is generally understood that inflammation plays a vital role in beta-cell destruction. But the precise factors are not well known. A protein-based enzyme found in beta cells, 12-LO produces specific lipids that cause inflammation and can lead to the death of beta cells in laboratory models. In fact, EVMS researchers have demonstrated that deleting the gene that produces 12-LO prevents the development of Type 1 diabetes in mice.

The challenge has been to validate that 12-LO and its pro-inflammatory lipid products have a role in h
'/>"/>

Contact: Jina Gaines
gainesjn@evms.edu
757-446-7070
Eastern Virginia Medical School
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... York, New York (PRWEB) October 25, 2014 ... transvaginal mesh lawsuits ( http://www.vaginalmeshlawsuit2015.com/ ) filed ... litigation underway in U.S. District Court, Southern District ... for Summary Judgment on Punitive Damages in a ... plaintiffs. In a ruling issued on October 21st, ...
(Date:10/25/2014)... 2014 Limbkeepers® announced today that they ... with Ed Begley Jr, airing 1st QTR 2015 via ... this episode, Innovations will focus on Limbkeepers® non compression ... thinning skin on arms, hands, and legs from abrasion, ... versatile products, which help reduce injuries, allow for continued ...
(Date:10/25/2014)... HealthDay Reporter FRIDAY, Oct. 24, ... sores -- herpes simplex -- might increase the risk of ... fact, being a carrier of certain antibodies to the virus ... "The identification of a treatable cause [herpes simplex] ... lead researcher Dr. Hugo Lovheim, an associate professor in the ...
(Date:10/25/2014)... 2014 (HealthDay News) -- Researchers who discovered antibiotics ... are cause for concern. The use of ... for human consumption contribute to the development of ... background information from the study. Each year ... 2 million people and kill about 23,000, according ...
(Date:10/25/2014)... FRIDAY, Oct. 23, 2014 (HealthDay News) -- Current ... many younger postmenopausal women at risk for osteoporosis-related ... want to prevent fractures, we need tools that ... osteoporotic injuries so that we can target these ... Carolyn Crandall, professor of medicine in the division ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4Health News:Upcoming Episode of Innovations with Ed Begley, Jr. to Feature Limbkeepers® 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 2Health News:Studies Link Cold Sore Virus to Alzheimer's Risk 3Health News:Researchers Say Antibiotics in Fish a Health Concern 2Health News:Osteoporosis Screening Guidelines May Miss Younger Women at Risk 2
... 11 (HealthDay News) -- Naturally conceiving and giving birth to twins ... , The study found that among women who were born in ... to live longer than the mothers of singletons. University of ... Utah Population Database who were born between 1807 and 1899 and ...
... how well someone will control their emotions? To predict ... stress? To accept critical feedback stoically? ... University, finds clues in what psychologists call "hot" and "cold" ... can control their emotions, and one factor that predicts it ...
... By Steven Reinberg HealthDay Reporter , TUESDAY, ... as erythropoietin alfa after a heart attack may experience new ... a new study finds. The drug, which stimulates red ... because certain studies suggested it might reduce the extent of ...
... and uninformed media portrayals of weight not only can ... approach issues of weight and health. The result, according ... (STOP) Obesity Alliance and the National Eating Disorders Association ... largely a matter of personal responsibility and that little ...
... Reporter , TUESDAY, May 10 (HealthDay News) -- Scientists have ... predict which breast cancer patients can benefit from specific types ... treatment, according to a study in the May 11 issue ... The findings are exciting but need to be replicated, ...
... , TUESDAY, May 10 (HealthDay News) -- Shortages of ... results of a new survey. The findings revealed that ... than 1,350 from the United States) are experiencing a shortage ... 98 percent of the respondents encountered a similar problem, the ...
Cached Medicine News:Health News:Moms Who Have Twins May Live Longer: Study 2Health News:When words get hot, mental multitaskers collect cool 2Health News:When words get hot, mental multitaskers collect cool 3Health News:Anemia Drug May Worsen Heart Attacks 2Health News:Anemia Drug May Worsen Heart Attacks 3Health News:Are words weighing down the development of policy for better health? 2Health News:Are words weighing down the development of policy for better health? 3Health News:Genetic Test Shows Promise in Guiding Breast Cancer Care 2Health News:Genetic Test Shows Promise in Guiding Breast Cancer Care 3Health News:Shortage of Anesthetics Reported 2
(Date:10/22/2014)... SAN FRANCISCO , Oct. 22, 2014 ... fitness and health trackers for themselves and their kids, ... Mom 2014 Report: Health & Fitness Go Mobile for ... Mom® Insights Series. BabyCenter, the number 1 pregnancy and ... which found that 55 percent of moms surveyed say ...
(Date:10/22/2014)... -- A new report by Allied Market ... End user, Application and Geography) - Size, Share, Global ... Segmentation and Forecast, 2013 - 2020", considers commercial aspects ... trends tracked, it is anticipated that the market is ... registering a CAGR of 6.2% from 2014 to 2020. ...
(Date:10/22/2014)... 2014 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral ... results from its Phase IIa clinical trial of ... treat type 1 diabetes. The trial was conducted in ... a U.S. Food and Drug Administration (FDA) Investigational ...
Breaking Medicine Technology:BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 4
... GeoVax Labs, Inc. (OTC BB: GOVX), an Atlanta-based, biopharmaceutical ... Immunodeficiency Virus (HIV) infections, today announced its financial results and ... 30, 2011. GeoVax reported a net loss of ... 30, 2011, compared to $933,089 ($0.06 per share) for the ...
... Spherix Incorporated (NASDAQ: SPEX ) ... metabolic syndrome and atherosclerosis, and providers of technical and ... companies – today reported financial results for the three ... Recent and Upcoming Highlights ...
Cached Medicine Technology:GeoVax Labs, Inc. Announces Second Quarter Financial Results 2GeoVax Labs, Inc. Announces Second Quarter Financial Results 3GeoVax Labs, Inc. Announces Second Quarter Financial Results 4Spherix Announces Second Quarter Financial Results 2Spherix Announces Second Quarter Financial Results 3Spherix Announces Second Quarter Financial Results 4Spherix Announces Second Quarter Financial Results 5Spherix Announces Second Quarter Financial Results 6Spherix Announces Second Quarter Financial Results 7
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: