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New study finds no benefit to selecting dose of blood thinner based on patients' genetic makeup
Date:11/19/2013

for the clinical-guided dosing group 35.2 percent versus 43.5 percent, respectively. Pharmacogenetic-based dosing also led to more over-anticoagulation and a longer time to first therapeutic levels of the warfarin among African Americans.

The authors note that despite the positive results from other smaller studies analyzing the benefits of gene-based prescribing therapy, the results of this trial do not support the hypothesis that initiating warfarin therapy at a pharmacogenetic-predicted maintenance dose improves anticoagulation control over clinical methods. They point out that previous studies were primarily conducted at single clinical sites, were not blinded, and involved a limited number participants. They conclude that the COAG trial emphasizes the importance of performing large randomized trials for additional pharmacogenetics approaches, particularly for complex medicine regimens such as warfarin.


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Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-796-4829
University of Pennsylvania School of Medicine
Source:Eurekalert

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