Navigation Links
New study finds no benefit to selecting dose of blood thinner based on patients' genetic makeup
Date:11/19/2013

DALLAS A new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania has determined that a gene-based method for selecting patients' doses of the popular heart medication warfarin is no better than standardized dosing methods. The study was presented today at the 2013 Scientific Sessions of the American Heart Association and published simultaneously in the New England Journal of Medicine.

"There has been much interest in the medical community about the utility of pharmacogenetics using information about a person's genetic makeup to choose the drugs and drug doses that are most likely to work well for that particular person to help better personalize treatments for patients and improve drug safety and efficacy," said lead study author Stephen Kimmel, MD, MSCE, professor of Medicine and Epidemiology at Penn Medicine. "Warfarin therapy has served as a model for the promise of a gene-based approach to patient care, but we needed a large, prospective clinical trial to determine if a patient's genetic information provides the added benefit above and beyond what can be obtained simply with clinical information."

Warfarin is a blood thinner used to prevent clots and is generally considered to be a very effective medication, but dosing must be properly adjusted for each patient, who are closely monitored for complications. Approximately 2 million Americans, primarily older patients, take warfarin to keep blood from excessive clotting, or coagulation. Currently, doctors face major challenges in determining the right dose of warfarin for each patient because individuals vary widely in how quickly their bodies' break down and respond to the drug. Taking too much warfarin could result in bleeding problems and taking too little warfarin will not stop clots from forming.

Previous research has shown that two genes, CYP2C9 and VKORC1, which vary among different individuals, can influence warfarin's eff
'/>"/>

Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-796-4829
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New study reports on the high cost of cardiac surgery healthcare associated infections
2. New Study May Impact Practice Guidelines for Mitral Valve Surgery for Severe Ischemic Mitral Regurgitation
3. Study may impact guidelines for mitral valve surgery for severe ischemic mitral regurgitation
4. Advanced CT imaging proves as accurate as invasive tests to assess heart blockages, study shows
5. Chicago man breathes again thanks to Northwestern Medicine study
6. Study finds youth prefer and benefit more from rapid point-of-care HIV testing
7. Study: Ureteral injury during robot-assisted prostate surgery
8. Study: Odds of rehospitalization of cognitively impaired varies by discharge destination
9. A CNIO study recreates the history of life through the genome
10. Dr. Joe Dentistry Promotes Dental Exams as New Study Links Heart Disease to Oral Health
11. Study questions hypothermia treatment for cardiac arrest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... Meadows, Ill. (PRWEB) , ... September 01, 2015 ... ... procedures done by members of the American Society for Dermatologic Surgery, according to ... , The 2015 ASDS Consumer Survey on Cosmetic Dermatologic Procedures – which reflects ...
(Date:9/1/2015)... Houston, TX (PRWEB) , ... September 01, 2015 ... ... announce that it is now offering the MonaLisa Touch® , an innovative ... , The MonaLisa Touch® is a new hormone-free treatment for atrophic vaginitis, a ...
(Date:9/1/2015)... NC (PRWEB) , ... September 01, 2015 , ... With ... Technology, Engineering and Math) disciplines since its inception more than 35 years ago. A ... high-school students and their teachers - and, not just those intent on pursuing careers ...
(Date:9/1/2015)... ... September 01, 2015 , ... WorkCare, Inc., a national ... medical management team as an Associate Medical Director. , WorkCare specializes in ... the U.S. and abroad. , Dr. Nelson has a diverse background. He ...
(Date:9/1/2015)... ... 01, 2015 , ... METTLER TOLEDO has announced an upcoming ... requirements“ , featuring Ed Szczesny (Quality Assurance, Rhodes Pharmaceuticals) as guest presenter. This ... , Calibration, qualification, and the appropriate level of routine testing for laboratory ...
Breaking Medicine News(10 mins):Health News:Survey: Consumers Prefer ASDS Members 2Health News:Survey: Consumers Prefer ASDS Members 3Health News:Houston's Plaza OB/GYN Now Offering the MonaLisa Touch® 2Health News:Houston's Plaza OB/GYN Now Offering the MonaLisa Touch® 3Health News:Inmar Announces Program to Fuel Student Passion for STEM – with an Unconventional Twist 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 3Health News:Live Webinar from Pharmaceutical Technology and METTLER TOLEDO on Calibration and Qualification of Laboratory Instruments 2
... for foreign markets and plans,Canadian rollout, ... (OTC,Bulletin Board: UKMA), a lifestyle multimedia and ... personal development, announced today that,its exclusive international ... Xflowsion DVD series at the Electronic,Retailer,s Association ...
... Determinations, WASHINGTON, Oct. 28 National ... Administration,s,new "Compassionate Allowances Process" for disability determinations, ... Before announcing this,proposal, Social Security held public ... information from experts. NPAF, in collaboration with ...
... could reduce the cost and time required for cancer ... 28 online issue of the Journal of the ... a multistep process that involves in vitro tests, animal ... Inadequately designed rodent studies have led to missteps and ...
... DURHAM, N.C. -- Popular cholesterol-busting drugs -- statins -- appear ... according to researchers in the Duke Prostate Center and the ... prevent prostate cancer growth or just mask it is not ... statins were less likely to develop advanced forms of prostate ...
... become a billion-dollar substitute for flying business people ... to make sound judgments about speakers being viewed ... in a journal of the Institute for Operations ... in the Field: A Heuristic Processing Model" is ...
... because it may worsen another is a treatment trade-off ... rather take part in, researchers at Yale School of ... Journal of the American Geriatrics Society . , ... least two chronic conditions, and 24 percent have four ...
Cached Medicine News:Health News:uKarma Reports Progress With International Distribution Agreement for Its Xflowsion DVD Series 2Health News:National Patient Advocate Foundation (NPAF) Commends SSA's New 'Compassionate Allowances Process' 2Health News:Cholesterol-lowering drugs may also lower PSA, but whether they cut cancer risk is still not known 2Health News:Videoconferencing more confusing for decision-makers than face-to-face meetings 2Health News:Elderly fare better when included in decisions on treatment trade-offs 2
(Date:9/1/2015)... --NOWDiagnostics Inc., based in Springdale, Ark. , ... Canada , a move that brings the company ... have greater access to information concerning their health. ... blood-based rapid tests that allow health care providers to ... ailments and diseases. ZBx Corporation, a Toronto ...
(Date:9/1/2015)... , Sept. 1, 2015 Konica Minolta ... Computed Radiography (CR) system, designed to deliver enterprise level ... utilizing the same Control Station as the Konica Minolta ... with an upgrade path from CR to DR. The ... to help improve workflow with unparalleled reliability and high ...
(Date:9/1/2015)... VEGAS , Sept. 1, 2015  Dr. ... DigiPath Labs , the cannabis testing subsidiary of DigiPath, ... Patients Group about the lack of consistency in ... the online resource for medical cannabis information, she explained ... patients because their lack of uniform requirements makes standardization ...
Breaking Medicine Technology:NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 3Konica Minolta Launches New CR System with Low-Cost Upgrade Path to DR 2DigiPath Labs CSO Dr. Cindy Orser Calls for Uniform Standards for Cannabis Safety Testing 2DigiPath Labs CSO Dr. Cindy Orser Calls for Uniform Standards for Cannabis Safety Testing 3
... the ADA,s Annual Scientific Sessions, SAN FRANCISCO, ... of the dose-finding study for its new,injectable diabetes ... American Diabetes Association,s (ADA) 68th Annual Scientific Sessions,meeting ... that AVE0010 was well tolerated and significantly,improved glycemic ...
... California, June 6 , - "ADVANCE Results ... the world,s largest ever study of diabetes treatments,show ... release,gliclazide and other drugs as required, protects patients ... treatment reduces,the risk of kidney disease by one-fifth. ...
Cached Medicine Technology:New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 2New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 3New Diabetes Compound AVE0010 Showed Clear Dose Response Results With Once-A-Day Injection in Phase IIb Study 4The Largest Ever Study of Diabetes Shows Intensive Glucose Control Reduces Serious Complications 2
... ergonomic chairs with concave seats ... support • Select options like ... and glides. • BTT/1P chairs ... environments: industry, education, laboratory, clean ...
... with concave seats and standard-sized ... Select options like seats, backrests, ... • BTT/1P chairs are recommended ... education, laboratory, clean room, static ...
... chairs with concave seats and large ... options like seats, backrests, armrests, and ... BE Series for top performance in ... education, laboratory, clean room, static control, ...
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... the BE Series for top performance ... industry, education, laboratory, clean room, static ...
Medicine Products: