Navigation Links
New study finds digoxin safe despite recent reports
Date:4/16/2013

CHICAGO --- A study published today in the European Heart Journal found no evidence that digoxin increases mortality in patients with atrial fibrillation (AF), the opposite of results just published by another group in the same journal analyzing the same data.

Older patients with AF also often have heart failure, and digoxin is approved to treat both conditions. AF is the most common kind of cardiac arrhythmia, an electrical malfunction that throws off the heart's rhythm and pumping rate. It may cause no symptoms or cause some patients to faint, but is seldom fatal. Heart failure, a gradual weakening of the heart's pumping strength, contributes to 280,000 U.S. deaths each year.

Both the earlier study that found digoxin increases mortality in AF and the study published today were re-analyses of data first collected as part of a clinical trial called Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) in 2002. The recent study that found digoxin increases mortality used an approach called "time-varying treatment," where patients who continued to receive digoxin over 3.4 years as part of the follow-up to AFFIRM were compared to those who did not.

According to current study, this "time-varying treatment" technique produced misleading results. By analyzing data from sicker patients who required continued digoxin treatment over the long term, it inadvertently introduced bias in its analysis of digoxin-related mortality.

"Digoxin is recommended by major national guidelines for use in heart failure and atrial fibrillation," said Mihai Gheorghiade, M.D., lead author of the study and professor of medicine and of surgery at Northwestern University Feinberg School of Medicine. "It is an inexpensive drug that is generally well tolerated at low doses, and there is no reason to question its usefulness or reassess its safety. We need to remember that although digoxin has been used for over two centuries, it
'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Babies Born Even Slightly Early May Lag Behind: Study
2. Study May Explain How Circumcision Reduces HIV Risk
3. New Study Links Air Pollution to Alzheimer’s Disease -- Says Cure Alzheimer's Fund
4. Study Questions Value of PSA Test for Older Men
5. Doctors Insight Into Patients Lives May Boost Care, Study Finds
6. Drug could improve working memory of people with autism, study finds
7. Freezing Treatment May Help Destroy Lung Tumors: Study
8. Age of Autism Diagnosis May Depend on Symptoms: Study
9. Laser Liposuction May Zap Fat Without Skin Sag: Study
10. In sex, happiness hinges on keeping up with the Joneses, CU-Boulder study finds
11. Vitamin D may reduce risk of uterine fibroids, according to NIH study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... WASHINGTON, DC (PRWEB) January 22, 2015 ... conditions in vulnerable communities and cause financial distress to ... report by analysts at Howard University’s Center on Race ... of dollars in economic activity, payday loans at the ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 As interest in ... health care gains momentum worldwide, Rev. Eric J. Hall ... Chaplaincy Network (HCCN), will be the keynote speaker on ... in Israel’s public health system. , The conference, “Hope and ...
(Date:1/22/2015)... a new blog post presenting a list of vehicles that cannot ... Some types of vehicles cannot be covered under an ordinary auto ... see if their vehicle qualifies for auto insurance coverage. , ... that cannot be covered by a plan. Clients have little options ...
(Date:1/22/2015)... Step into a macabre world where plants ... Virginia. Wicked Plants, the Museum’s latest featured exhibition, opens ... carnivorous and diabolical plants inside of a dilapidated, Victorian ... biochemical, physical and neurological processes between botanicals and the ...
(Date:12/26/2014)... December 26, 2014 The US represents the ... report. In 2013, GlobalData’s forecast estimates that sales of branded ... market due to the high incidence of the disease, high ... 5EU, Japan, and China. Increased sales of CRC therapies over ...
Breaking Medicine News(10 mins):Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
... Located and Successfully Treated, ASHEVILLE, N.C., Aug. 30 ... this afternoon and has returned to his,mountain home in ... vehicle and made the 20-minute drive home without incident. ... Hospitals in Asheville, NC,early on Saturday, August 18 for ...
... 30 Omnicell, Inc.,(Nasdaq: OMCL ) a leading ... operational efficiency in healthcare,facilities, today announced that Randall A. ... & CFO will present at the Thomas Weisel,Partners Healthcare ... Wednesday, September 5, 2007 at 11:30 a.m. Eastern Time. ...
... today announced that the Department is making available ... areas to help,strengthen their capacity to respond to ... will provide our nation,s health care community,with a ... equipment,for an effective pandemic response," Secretary Leavitt said. ...
... to October 15, 2007, RICHMOND, Va., Aug. 30 ... through organ and tissue donation in,2006, strongly held myths ... Hispanics from becoming organ and tissue donors. In,recognition of ... and encourage the Hispanic community, long celebrated for its,zest ...
... Va., Aug. 30 Ronald Honberg,director of policy and ... issued the following statement on today,s Virginia Tech,Panel Report: ... It exposes problems,that exist not just in Virginia but ... system received a ,D, grade in,a national survey. The ...
... 6-7, Mandarin Oriental, Washington, D.C., ARLINGTON, ... industry,CEOs, along with top Wall Street analysts ... other government officials, will headline the,Generic Pharmaceutical ... 2007. The conference, "Generics: Prescription for Affordable,Health ...
Cached Medicine News:Health News:Billy Graham Home After Hospitalization: 2Health News:Omnicell to Present at Thomas Weisel Healthcare Conference 2007 2Health News:HHS Announces $75 Million in Supplemental Funding to States for Pandemic Flu Preparedness 2Health News:Donate Life America Dispels Myths About Organ & Tissue Donation Among Hispanics During National Hispanic Heritage Month 2Health News:Virginia Tech Report Has National Importance 2Health News:GPhA's 2007 Annual Policy Conference Features Top Generic Industry CEOs; FDA, Government Officials; Wall Street Analysts 2
(Date:1/23/2015)... Pa. , Jan. 23, 2015  MedScope ( www.medscope.org ... been nominated for a 2015 Connected World ... Emergency Response System (mPERS), that can be used anywhere, ... technology partner.  In nominating MedScope, ...
(Date:1/23/2015)... /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) is investigating potential ... ("Advaxis" or the "Company") (NASDAQ: ADXS ), ... to shareholders. On January 21, 2015, an ... Advaxis had misrepresented the clinical data for its ADXS-HPV ...
(Date:1/23/2015)... Idaho , Jan. 23, 2015  Now available for ... No. 7,849,611) support that prevents ankle sprains by cushioning ... brace, it fits securely around the outside of any ... mobility & comfort while still offering protection against sprains. ...
Breaking Medicine Technology:MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2
... A particular challenge in transseptal left heart ... must be exchanged for a sheath with ... wall position. Traditionally, such an exchange has ... heparinized patient. Biosense Webster has overcome this ...
... of guiding introducers includes Swartz™ Series, ... piece steerable, all designed for the ... varying curves and longer sheath lengths ... Jude Medical guiding introducers are designed ...
Novus 30001 A fully-integrated and powerful 532 nm Operating Room Photocoagulator with reliable DPSS technology and simplified operation using a touch screen interface and remote control....
... 1064 nm Nd:YAG Base Platform ... ophthalmologists treating the anterior segment ... the elimination of secondary cataracts ... Selecta platform offers multiple upgrade ...
Medicine Products: