Navigation Links
New study explains how organs coordinate their development with the whole body
Date:6/20/2014

This news release is available in Portuguese.

This news release is available in Portuguese.

A research group led by Christen Mirth at Instituto Gulbenkian de Cincia (Portugal) uncovered that the development of wings in fruit flies does not progress synchronously with the organism's development. Instead, it is coordinated with the whole body only at distinct 'milestones'. This study, published in the latest issue of the scientific journal PLOS Genetics*, helps explain how an organism facing environmental and physiological perturbations retains the ability to build correct functional organs and tissues in a proportional adult body.

For a growing organism it is essential to have robust developmental processes ensuring that the developing organs and tissues are formed correctly even in the face of environmental or physiological perturbations. To achieve robustness, the processes that generate individual organs must, at some level, be integrated across the whole body to ensure that a correctly patterned and proportioned adult is produced at the end of development. Christen Mirth and colleagues proposed to study how organ and whole-body development is coordinated, using the fruit fly, Drosophila melanogaster, as a model organism. The juvenile period in the fruit fly comprises three larval moults, followed by a wandering stage where larvae leave the food and search for a site to begin metamorphosis at a stage called pupariation. The research team focused on these so-called developmental events to study how the development of wings is coordinated with the whole body of the fruit fly larvae.

The researchers first analysed the expression of six genes involved in the development of wings in normal conditions of growth, i.e. at a temperature of 25C, and generated a detailed staging scheme. Next, the researchers changed the temperature to affect the growth conditions of the larvae and analyzed the rate of wing development compared to the whole-body development. It is known that flies grow faster at higher temperatures and grow slower at lower temperatures. However, the researchers observed that the development of the wings was slower at 29C, compared to flies growing in normal conditions or flies growing at 18C. "This result surprised us, as we could clearly observe a delay in the development of these wings in wandering stage larvae, but their progression accelerated towards the stage of pupariation. This means that development shows variability in its progression, but converges at the milestone of pupariation", explains Marisa Oliveira, first author of this study.

Next, researchers modified the larval physiology by interfering with the hormone ecdysone that regulates the different developmental events in the larvae, such as wandering and pupariation. Similar to the temperature manipulations, when they altered the timing of ecdysone synthesis, they found that the wings developed slowly at first, but accelerated their development to achieve coordination at the stage of pupariation.

These results support the hypothesis proposed by this research team, that the development of the wings, in the fruit fly, is aligned with the whole-body development at two milestones: moulting and pupariation.

Marisa Oliveira concludes: "With this work we propose a new paradigm for thinking about organ-organ and organ-body coordination during development. We suggest that organisms achieve this coordination not by continuous but rather by discrete communication focused on developmental milestones".

Christen Mirth adds: "The next challenge is to understand the nature of this communication at milestones."


'/>"/>

Contact: Ana Mena
anamena@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/17/2017)... ... February 17, 2017 , ... Corrective ... Warning Letter, **An FDAnews Webinar**, Feb. 23, 2017 — 1:30 p.m. – 3:00 ... corrective action (CA) and preventive action (PA)? , The methods share techniques and ...
(Date:2/17/2017)... ... February 17, 2017 , ... MAP ... today that Karen Pilley has been promoted to Chief Executive Officer. , ... healthcare paradigm – a shift that demands the transition from pay-for-service to pay-for-performance ...
(Date:2/17/2017)... ... ... Like most hospitals across the nation, Onslow Memorial Hospital is looking for more ... Program (HRRP), the return of a patient to the hospital within 30 days of ... providers are struggling to leverage limited resources and technology, Onslow Memorial Hospital has saved ...
(Date:2/16/2017)... ... February 17, 2017 , ... Harsha Chigurupati ... years of research, development and clinical trials, the founder of Chigurupati Technologies has ... compound of FDA approved ingredients that when infused into alcohol, protect the consumer’s ...
(Date:2/16/2017)... ... February 16, 2017 , ... As a reflection of ... care, NWH has achieved Magnet® recognition for the second time, announced ... The American Nurses Credentialing Center’s Magnet Recognition Program® distinguishes organizations that meet rigorous ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... DUBLIN , Feb. 17, 2017 ... ("Theravance Biopharma" or the "Company") today announced the ... novel, potent, and orally administered pan-Janus kinase (JAK) ... 12 th Congress of the European Crohn,s ... the Company reported further data from its completed ...
(Date:2/17/2017)... Research and Markets has announced the addition of the "Drug-Eluting ... ... for the US, Canada , Japan ... Latin America , and Rest of World. Annual estimates and ... historic analysis is provided for these markets. Market data and analytics are ...
(Date:2/17/2017)... LOUIS , Feb. 17, 2017   FormFast ... has announced a new partnership with Engage , ... the United States . FormFast will serve as ... of Engage,s implementations with MEDITECH .  ... provides essential functionality to complement and enhance the electronic ...
Breaking Medicine Technology: