Navigation Links
New study explains how organs coordinate their development with the whole body
Date:6/20/2014

This news release is available in Portuguese.

This news release is available in Portuguese.

A research group led by Christen Mirth at Instituto Gulbenkian de Cincia (Portugal) uncovered that the development of wings in fruit flies does not progress synchronously with the organism's development. Instead, it is coordinated with the whole body only at distinct 'milestones'. This study, published in the latest issue of the scientific journal PLOS Genetics*, helps explain how an organism facing environmental and physiological perturbations retains the ability to build correct functional organs and tissues in a proportional adult body.

For a growing organism it is essential to have robust developmental processes ensuring that the developing organs and tissues are formed correctly even in the face of environmental or physiological perturbations. To achieve robustness, the processes that generate individual organs must, at some level, be integrated across the whole body to ensure that a correctly patterned and proportioned adult is produced at the end of development. Christen Mirth and colleagues proposed to study how organ and whole-body development is coordinated, using the fruit fly, Drosophila melanogaster, as a model organism. The juvenile period in the fruit fly comprises three larval moults, followed by a wandering stage where larvae leave the food and search for a site to begin metamorphosis at a stage called pupariation. The research team focused on these so-called developmental events to study how the development of wings is coordinated with the whole body of the fruit fly larvae.

The researchers first analysed the expression of six genes involved in the development of wings in normal conditions of growth, i.e. at a temperature of 25C, and generated a detailed staging scheme. Next, the researchers changed the temperature to affect the growth conditions of the larvae and analyzed the rate of wing development compared to the whole-body development. It is known that flies grow faster at higher temperatures and grow slower at lower temperatures. However, the researchers observed that the development of the wings was slower at 29C, compared to flies growing in normal conditions or flies growing at 18C. "This result surprised us, as we could clearly observe a delay in the development of these wings in wandering stage larvae, but their progression accelerated towards the stage of pupariation. This means that development shows variability in its progression, but converges at the milestone of pupariation", explains Marisa Oliveira, first author of this study.

Next, researchers modified the larval physiology by interfering with the hormone ecdysone that regulates the different developmental events in the larvae, such as wandering and pupariation. Similar to the temperature manipulations, when they altered the timing of ecdysone synthesis, they found that the wings developed slowly at first, but accelerated their development to achieve coordination at the stage of pupariation.

These results support the hypothesis proposed by this research team, that the development of the wings, in the fruit fly, is aligned with the whole-body development at two milestones: moulting and pupariation.

Marisa Oliveira concludes: "With this work we propose a new paradigm for thinking about organ-organ and organ-body coordination during development. We suggest that organisms achieve this coordination not by continuous but rather by discrete communication focused on developmental milestones".

Christen Mirth adds: "The next challenge is to understand the nature of this communication at milestones."


'/>"/>

Contact: Ana Mena
anamena@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a boisterous story about ... as God intended. “The Adventures of Joey, The Dog Who Barks at Puddles” is ... for writing, especially about truth and human behavior. , Published by Christian Faith Publishing, ...
(Date:3/23/2017)... ... 2017 , ... The physicians of KSF Orthopaedic Center PA are proud to ... location is located at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 ... provide patients living in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... Oklahoma City Convention Center at 10 North Broadway Avenue, will be an educational ... of relevant, practical instruction in the management of chronic pain. , Oklahoma is ...
(Date:3/23/2017)... ... ... are unaware of the dangers that infectious bacteria play in mouth disease, while 1 out ... that dentists recommend. The ramifications of improper oral upkeep go far beyond bad breath and ... hours of work each year due to dental issues. That is why Mediaplanet is proud ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... SmartBen NOW, an innovative mobile app and centralized benefits dashboard solving one of ... information securely from multiple locations. For the first time, employees can access up-to-date ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... SAN DIEGO , March 24, 2017  GenomeDx ... (Genomics Resource Information Database) and Decipher® Prostate Cancer Classifier ... Annual European Association of Urology (EAU) Congress held March ... . The Annual EAU Congress is ... and most comprehensive research in the urological field. ...
(Date:3/24/2017)... , March 23, 2017  Provectus Biopharmaceuticals, ... the "Company"), a clinical-stage oncology and dermatology biopharmaceutical ... Definitive Financing Commitment Term Sheet (the "Definitive Financing") ... group of the Company,s stockholders, who are referred ... in a Form 8-K filed with the Securities ...
(Date:3/23/2017)... , March 23, 2017 Mosaic Life Care, based in St. ... registration process across its network of 58 clinics, located in 22 cities, and its ... and innovative ways to improve the delivery of health care to its patients, including ... ... Mosaic Life Care St. Joseph Medical Center ...
Breaking Medicine Technology: