Navigation Links
New study confirms benefits of treating heart attack patients with a cheap drug
Date:3/30/2014

The initial results of this trial were published a few months ago (Circulation. 2013;128:1495-1503), and showed that patients who received this treatment during emergency transit to hospital had much smaller amounts of dead heart muscle than those randomly assigned to receive no treatment. The new study shows that the proportion of patients with a severely deteriorated heart contractile function is much less (60%) in the group that received metoprolol. Early treatment with metoprolol treatment also significantly reduced the rate of hospital readmission for chronic heart failure, and massively reduced the need to implant a cardioverter-defibrillator.

Borja Ibezjoint lead investigator on the study with Valentn Fusterexplains that "the possibility to reduce so dramatically the number of cases of chronic heart failure (with all the associated treatments and hospital readmissions) with such a cheap procedure (the metoprolol treatment costs less than two euros per patient) could generate enormous savings for health services across Europe."

An initial estimate indicates that if half the heart-attack patients in Europe received early treatment with this cheap drug, the savings in treatment for heart failure alone could exceed 10 billion a year. But as Dr. Fuster is careful to emphasize, it is important to remain cautious, and these estimates will need to be confirmed in a much larger study population across Europe. The research team is already preparing a new clinical trial, with more than 3000 patients in several European countries, which will be powered to demonstrate a reduction in mortality with this treatment. According to the authors, "The results presented today and published simultaneously in this issue of JACC are unprecedented and extremely promising, but rigorous clinical investigation requires corroboration in an independent population." The European consortium for this larger scale study, which will be led from Spain by the CNIC, is already being formed, and includes renowned researchers from Belgium, the Netherlands, Germany, France, Denmark, Serbia, Poland, Sweden, and the United Kingdom.

Dr. Borja Ibez, leader of the Imaging in Experimental Cardiology group at the CNIC and cardiologist at the Hospital Clnico San Carlos, emphasizes that the new study "will be a flagship project for our country that reinforces Spain's international leadership in research into cardiovascular diseases." The CNIC, a center dedicated to the study of cardiovascular diseases, has been led by internationally renowned cardiologist Dr. Valentn Fuster since 2007. Since Dr. Fuster's arrival, the CNIC has become an international reference center, and the leadership of studies such as the one published today demonstrates the high quality of cardiovascular research in our country.

Dr. Gonzalo Pizarro, one of the first authors on the study, comments that "it has been possible to demonstrate the beneficial and sustained effect of this acute treatment thanks to the realization of advanced cardiac magnetic resonance analysis of almost all the patients in this clinical trial." The CNIC is recognized for its expertise and research in different imaging technologies, particularly magnetic resonance imaging. The center runs a range of training programs in cardiovascular imaging in collaboration with the Mount Sinai School of Medicine, which is also directed by Dr. Fuster. Many of the cardiologists who contributed to the design, performance and analysis of the MRI scans in the METOCARD-CNIC trial, including Drs. Pizarro and Fernndez-Friera (joint first authors on the study), received training on these programs, and now work at the CNIC, combining their research activity and their clinical work in the Spanish hospital network.

This is one of the first studies to reveal extraordinary benefits from very early interventionin this case with metoprololduring the first contact with the emergency medical services. Dr. Vicente Snchez-Brunete, a doctor with the ambulance service SUMMA112 and a principal co-investigator on METOCARD-CNIC is in no doubt about the significance of the study, which has "highlighted the importance of the out-of-hospital emergency medical services, which are the first link in the chain of patient care. We have indirect data showing the earlier the patient receives metoprolol during a heart attack, the greater the benefit."

The active participation of the emergency medical services (SUMMA112, 061 Galicia and SAMUR) in METOCARD-CNIC has been voluntary. As Snchez-Brunete explained, "the professionals in the emergency medical services were motivated by the promise of this treatment to change clinical guidelines and the perception that the study was motivated purely by scientific interest."


'/>"/>
Contact: AInhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares
Source:Eurekalert

Related medicine news :

1. New study finds strong link between obesity and carb breakdown gene
2. Study compares heart valve systems
3. Study estimates proportion of adults affected by new blood pressure guideline
4. Study finds astronauts hearts become more spherical in space
5. Marriage linked to lower heart risks in study of 3.5+ million adults
6. Study shows promise of preserving fertility in boys with cancer
7. Scripps Florida scientist awarded $2.3 million to study dengue fever and related viruses
8. Hormone levels linked to survival of deer calves, study suggests
9. Study identifies key player in motor neuron death in Lou Gehrigs disease
10. Statins could ease coughing in lung disease patients, study finds
11. HPV eradicated by AHCC supplement, preclinical study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... August 21, 2017 , ... Duncan Insurance Agency debuts the ... of Michigan. The new initiative fundraises for the Kalamazoo Humane Society (KHS), which ... animal protection and welfare by addressing the root causes of pet overpopulation. As ...
(Date:8/21/2017)... ... August 21, 2017 , ... San Diego physician and surgeon Dr. James Veltmeyer, ... announced his candidacy for the 52nd Congressional District currently held by Representative Scott Peters. ... to this country at age eleven after suffering homelessness and hardship in a distant ...
(Date:8/20/2017)... ... August 20, 2017 , ... HIPAA ... Management System has assisted multiple clients in successfully passing audits such as ... Control Level 2 (AICPA SOC Level 2), and State Data Use Agreement Audits. ...
(Date:8/19/2017)... (PRWEB) , ... August 18, 2017 , ... Western University ... health and education to launch the University’s new Center for Innovation on Wednesday, September ... Health Education Center Lecture Hall 1, followed by a technology exhibition from 1 to ...
(Date:8/19/2017)... ... August 19, 2017 , ... Curl Keeper® is excited ... The Curl Leaders, Editors’ Choice 2017 Award for the second year in a row. ... stylists and curlies alike was voted Best Moisturizer for Type 2 Wavies and Best ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)...  Life Flight Network and PeaceHealth Oregon Network announced they ... and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, Oregon ... Flight Network work collaboratively to move patients who require the ... time sensitive emergency exists. ...
(Date:7/31/2017)... Pharmacy, Inc. (NYSE: DPLO), has been named one of the ... Crain,s Detroit Business . The annual Crain,s Fast ... growth. This year,s edition measures growth from 2013 to 2016. ... list, visit crainsdetroit.com/awards/fast_50/2017 .  "Being named ... Phil Hagerman , CEO and chairman of Diplomat. "We,ve made ...
(Date:7/28/2017)... 2017 Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... ended June 30, 2017, and updated its financial outlook ... For the fiscal third quarter, Hill-Rom reported earnings ... diluted share in the prior-year period. These results reflect ... diluted share primarily related to the non-cash write-down of ...
Breaking Medicine Technology: