Navigation Links
New study aims to reduce risk of childhood leukemia
Date:1/25/2009

A study led by Dr Marcus Cooke at the University of Leicester and funded by World Cancer Research Fund (WCRF) UK is looking at whether consuming caffeine during pregnancy might affect the unborn baby's risk of developing leukaemia in childhood.

Dr Cooke sees the study as a unique opportunity to determine the sources of chromosomal alterations during pregnancy, with the ultimate aim of reducing the risk of childhood leukaemias.

Leukaemia is a cancer of the bone marrow and white blood cells. It can affect people of all ages and around 7,000 cases are diagnosed each year in the UK. While it is the most common type of childhood cancer, accounting for 35 per cent of cases, it is still rare. Only 1 in 10 of leukaemia patients are children, accounting for 500 child diagnoses a year in the UK.

"We want to find out whether consuming caffeine could lead to the sort of DNA changes in the baby that are linked to risk of leukaemia," said Dr Cooke. "This is an important area of research because it is vital that mothers are given the best advice possible."

While childhood leukaemia could be initiated by DNA alterations in the unborn child, it is thought that leukaemia would only develop if there was another secondary trigger. There is currently no single proven cause of childhood leukaemia, though exposure to radiation and/or a rare response to a common infection are thought likely to play a part.

Although there are currently no convincing links between caffeine and cancer risks, previous studies have found a link between alterations to DNA, which are sometimes found in newborn babies, to an increased risk of leukaemia. Caffeine has been shown to cause these kinds of changes to DNA.

Scientists know caffeine can pass back and forth across the placenta, meaning the unborn baby will come in contact with caffeine consumed by the mother. Dr Cooke and his team want to find out what impact this can have on the unborn baby.

Their research will involve working with a group of 1,340 pregnant women. After birth, a blood sample is routinely taken from each newborn baby's heel. It is these samples that will then be tested for DNA changes. By comparing any DNA changes to the levels of caffeine the mother consumed, the team will try to find out if the two are linked.

If a link is discovered, further research would be needed to see whether this meant babies with these DNA changes would be more likely to develop leukaemia, and to examine evidence of exposure to other DNA damaging agents. The study will also collect other lifestyle and dietary data to see if there are other factors which might increase the risk.

Dr. Marcus S. Cooke, of the Leicester Department of Cancer Studies, and the Department of Genetics, will be working with Drs. Roger Godschalk and Sahar Barjesteh van Waalwijk van Doorn-Khosrovani from the Department of Health Risk Analysis and Toxicology, Maastricht University.

This study is not the first research into the link between cancer risk and caffeine. In the past, research has suggested a possible link with cancers of the pancreas and kidney, but after examining all the research, the WCRF/AICR Expert Report found that a substantial effect on risk was unlikely.

The Food Standards Agency advises pregnant women not to consume more than 200mg of caffeine a day which is equivalent to two cups of coffee and WCRF UK supports this advice. Evidence suggests drinking a lot of caffeine during pregnancy could be a factor in low birth weight, which has been linked to future risk of heart disease and diabetes.


'/>"/>

Contact: Dr. Marcus Cooke
msc5@leicester.ac.uk
44-011-625-25825
University of Leicester
Source:Eurekalert

Related medicine news :

1. Children with inflammatory bowel disease have surprisingly high folate levels, study finds
2. Children with Inflammatory Bowel Disease Have Surprisingly High Folate Levels, Study Finds
3. UCI behind worlds first embryonic stem cell study in humans
4. First Study to Test Real-World Effects of Stun Gun Use Raises Questions about Safety
5. UNC study: Access to state childrens health insurance programs vital to disabled children
6. New stretchable electrodes created to study stresses on cardiac cells
7. MedX Health Announces Initiation of Laser Acupuncture Study for Controlling Addiction
8. AutoGenomics CYP 2C19 Test Used in Study to Personalize Clopidogrel (Plavix) Dosing in Patients
9. UNC study: Postmenopausal womens loss of sexual desire affects health, quality of life
10. MSU researcher receives $1.5 million grant for childhood obesity intervention study
11. UC Davis study links smoking with most male cancer deaths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... Russ ... announced the first national #QuackGivesBack campaign which supported local breast cancer organizations during ... franchise-wide Quack Gives Back initiative, and we’re very pleased with the ...
(Date:12/8/2016)... ... 08, 2016 , ... Mirixa Corporation , a leading ... pharmacist-delivered patient care services, has announced the promotions of Karen Litsinger to senior ... of sales. , Litsinger joined Mirixa in 2008 after serving as a ...
(Date:12/8/2016)... ... ... David J. Dykeman , Ginger Pigott , and J. Rick ... West, Dec. 12, 2016, at the Fairmont Newport Beach in California. Greenberg Traurig is ... Sciences & Medical Technology Group have been featured speakers at every DeviceTalks conference since ...
(Date:12/8/2016)... , ... December 08, 2016 ... ... Suite 10.2 version gives development continuity to its innovative Unified Instance Manager ... management capacity. In addition, this new version optimizes the unattended auto-dialing system ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... STAT courier ... to be a convenient service for Texas, they are expanding their presence in Dallas. ... a hiring spree that will bring new jobs to the Dallas and Forth Worth ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... and Markets has announced the addition of the "Endodontic Supplies - Global ... , ... markets for Endodontic Supplies in US$ Thousand. The report provides separate comprehensive analytics ... Europe , Asia-Pacific , Latin ... are provided for the period 2015 through 2022. Also, a six-year historic analysis ...
(Date:12/8/2016)... 2016 Bodycad announced it has been ... accuracy, reproducibility and speed for 3D constructs via ... bone orthopaedic applications. These patents are critical to ... restorations based on each patient,s distinct anatomy. ... harnesses the world,s first suite of orthopaedic CAD/CAM ...
(Date:12/8/2016)... True Health Diagnostics today announced a ... and management expertise to hospital systems throughout ... doctors and patients to benefit from state-of-the-art biomarker ... Logo - http://photos.prnewswire.com/prnh/20161208/447162LOGO ... to contain costs, have struggled to keep up ...
Breaking Medicine Technology: