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New studies highlight obesity's impact on gastrointestinal health
Date:10/18/2010

ith the control group of patients with just CAD, implying that IBD is an independent risk factor for CAD.

"Recurrent flares of intestinal mucosal inflammation leads to the presence of excess pro-inflammatory cytokines and serum soluble adhesion molecules in IBD that could promote atherosclerosis-related inflammation, alter lipid metabolism, and contribute to plaque instability and rupture," said researcher Tarun Rustagi, M.D., of the Department of Internal Medicine, University of Connecticut. "Our results are in accordance with those published by smaller studies." Dr. Rustig also explained that further prospective cohort studies are needed to accurately investigate the incidence of CAD in patients with IBD.

In other findings, Crohn's disease patients who are overweight or obese (BMI>25) are more likely to have more severe disease characterized by a higher likelihood of Vitamin D deficiency, stricturing ileocolonic disease, and are more likely to require surgery compared to normal weight patients (BMI < 24.9) with Crohn's disease, according to the study, "The Clinical Phenotype of Obese and Overweight Crohn's Disease Patients."


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Contact: Jacqueline Gaulin
jgaulin@acg.gi.org
202-255-5541
American College of Gastroenterology
Source:Eurekalert

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