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New studies highlight obesity's impact on gastrointestinal health
Date:10/18/2010

tery disease (CAD) in patients with NAFLD. NAFLD is a very common disorder and refers to a group of conditions where there is accumulation of excess fat in the liver of people who drink little or no alcohol. Both NAFLD and CAD are complications of metabolic syndrome.

A total of 93 patients who had a suspicion of CAD and were scheduled for cardiac catheterization were included in the study, "High Prevalence of Coronary Artery Disease (CAD) in Patients with Non‐Alcoholic Fatty Liver Disease (NAFLD)," which found that among the 60 patients with available abdominal imaging, the prevalence of NAFLD was 30 percent.

"These patients who were found to have NAFLD were older, more commonly male, had higher weight and were also more commonly diabetic, hypertensive and had hyperlipidemia," explained researcher Noreen Hossain, M.D., of the Center for Liver Diseases, Inova Fairfax Hospital, Fairfax, Va. "The prevalence of angiographically-proven coronary disease in the NAFLD cohort was 61 percent compared to 26 percent in the non-NAFLD controls," said Dr. Hossain.

"As a result, NAFLD is strongly associated with angiographically-proven CAD," explained Dr. Hossain. "We found that diabetes is independently associated with both NAFLD and CAD."

Is Inflammatory Bowel Disease A Risk Factor for Coronary Artery Disease?

The link between chronic bowel inflammation and coronary artery disease (CAD) was explored in another study, "Is Inflammatory Bowel Disease a Risk Factor for Coronary Artery Disease," which focused on 79 patients who had confirmed inflammatory bowel disease (IBD) and CAD diagnosis. Forty-six patients had ulcerative colitis and 52 percent were males in the study group, compared to 40 percent males in the control group. Using the Framingham risk score FRS), which is calculated based on age, sex, hypertension, diabetes, tobacco use, total cholesterol and HDL values, the study found that FRS was lower in patients with IBD and CAD compared w
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Contact: Jacqueline Gaulin
jgaulin@acg.gi.org
202-255-5541
American College of Gastroenterology
Source:Eurekalert

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