San Antonio, Texas (October 18, 2010) The association between obesity and gastrointestinal-related cancers and coronary artery disease; the link between an overweight or obese body mass index and the severity of Crohn's disease; and whether inflammatory bowel disease is an independent risk factor for coronary artery disease, were among the highlights of new research that was presented this week at the American College of Gastroenterology's (ACG) 75th Annual Scientific meeting in San Antonio.
Obesity Linked to Increased Liver Cancer Risk, Adenoma Recurrence
Although liver cancer (hepatocellular carcinoma/HCC) in the absence of cirrhosis, fibrosis or hepatitis B is a rare occurrence, estimates show up to 10 percent of liver cancer occurs in non‐cirrhotic livers.
"Previous studies have suggested that obesity and insulin resistance may be risk factors for non-cirrhotic hepatocellular carcinoma, prompting us to analyze data from a cohort of 12 patients with non-cirrhotic HCC who underwent partial hepatectomy between January 2008 and September 2009 at a single center," said researcher Benjamin Mitlyng, M.D., a fellow with the University of Minnesota's Division of Gastroenterology, Hepatology and Nutrition. "We evaluated preoperative data including age, gender, presence of liver disease, body mass index (BMI), number of lesions and other comorbidities; data related to the resection, such as background history, tumor size, and vascular invasion; as well as post-operative complications and mortality," Dr. Mitlyng explained.
The study, "Hepatocellular Carcinoma in the Non-Cirrhotic Liver is Associated With a High Body Mass Index Independent of Steatosis," found that patients with non-cirrhotic HCC had a high prevalence of diabetes and elevated BMIs despite a lack of steatosis. However, even with advanced disease, patients tolerated resection very well with minimal complications, no operative mortality and average tumor-free follow-up of
|Contact: Jacqueline Gaulin|
American College of Gastroenterology