Navigation Links
New stretchable electrodes created to study stresses on cardiac cells
Date:1/22/2009

WEST LAFAYETTE, Ind. - Engineers at Purdue and Stanford universities have created stretchable electrodes to study how cardiac muscle cells, neurons and other cells react to mechanical stresses from heart attacks, traumatic brain injuries and other diseases.

The devices are made by injecting a liquid alloy made of indium and gallium into thin microchannels between two sheets of a plastic polymer, said Babak Ziaie, a Purdue associate professor of electrical and computer engineering.

Cell cultures are grown on top of the new "stretchable cell culture platform."

"We designed a simple and cost-effective process for fabricating these stretchable platforms," said Ziaie, who is working with Beth L. Pruitt, an assistant professor of mechanical engineering at Stanford, along with graduate students and other researchers at both universities. "What's special about this technology is that it allows you to electrically stimulate or monitor the cell population using electrodes while you are applying stress to the cells."

Stretching the cell cultures causes mechanical stresses like those exerted on tissues during heart attacks and traumatic brain injuries. The researchers have grown mice cardiac muscle cells on the platform and may grow cell cultures of neurons in future work. Cultures of stem cells also could be tested using the system to determine how mechanical stresses prompt the cells to differentiate into specific types of tissues, Ziaie said.

"You cannot stretch solid metal beyond a few percent because it will break, but we've been able to stretch these liquid platforms more than 40 percent of their original size," Ziaie said.

Findings are detailed in a paper being presented Monday (Jan. 26) during the 22nd IEEE International Conference on Micro Electro Mechanical Systems. The conference, sponsored by the Institute of Electrical and Electronics Engineers, will be in Sorrento, Italy.

"We demonstrated that the platform is biocompatible with human aortic muscle cells and mice heart cells," Ziaie said. "The cells adhered well to the polymer surface during mechanical strain and survived near and on the electrodes after two days of incubation. The platform also maintained its electrical capabilities after being stretched 100 times."

Purdue researchers designed and fabricated the platform at the Birck Nanotechnology Center in Purdue's Discovery Park. Stanford researchers grew cardiac muscle cell cultures on the device and tested the platform.

"We now hold the record for how much you can stretch an electrical conductor," Ziaie said.


'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Related medicine news :

1. The Association for the Advancement of Wound Care has Created the Wound Care Specialty Council
2. Exstream Software by HP Announces 2008 Visionary Award Winners : Customers Showcase Innovative Applications Created using the HP Exstream Enterprise Document Automation Solution
3. Not All Smiles Are Created Equal
4. Test Results from Pharmacy Healthcare Solutions Show not all Prescription Packaging is Created Equal
5. Study finds not all hearing aids are created equal
6. 80 Million Americans Can Benefit from New Diabetes Resource : Free Educational Website Created by UCSF Diabetes Teaching Center Goes Live
7. Susan Byrne joins GHG Grey Healthcare Group as EVP, Strategy and Business Development, Europe, a Newly-Created Position
8. Hearts Stem Cells Not Created Equally
9. Not all smoke alarms created equal
10. Cancer Stem Cells Created in Lab
11. Basis created for directing and filming blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New stretchable electrodes created to study stresses on cardiac cells
(Date:8/20/2017)... ... August 20, 2017 , ... HIPAA Solutions, LC ... has assisted multiple clients in successfully passing audits such as Office of ... 2 (AICPA SOC Level 2), and State Data Use Agreement Audits. , ...
(Date:8/19/2017)... , ... August 19, 2017 , ... ... Begley, Jr., will feature the Aurum Group in an upcoming episode, slated to ... segment of Innovations will feature the Aurum Group; a company committed to supporting ...
(Date:8/19/2017)... ... August 18, 2017 , ... President ... of 2017, legislation that provides for greater public access to over-the-counter (OTC) hearing ... to access OTC hearing aids without being seen by a certified and licensed ...
(Date:8/19/2017)... ... August 19, 2017 , ... Praeclarus Press has ... These illustrations show the diversity of the breastfeeding mothers, using bright colors ... of sizes. These illustrations are also available on tote bags, notepads, smartphone cases, ...
(Date:8/19/2017)... ... August 19, 2017 , ... Physician Partners ... Orlando location as an interventional pain management physician. He brings a wealth of ... of migraine headaches, and significant experience in spinal cord stimulation for chronic pain. ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... , Aug. 3, 2017  Agragen, LLC, ... company active in the biopharmaceutical, nutraceutical, and aquacultural ... development of its lead drug candidates, AGR131.  This ... proinflammatory cytokine from the blood of patients suffering ... and inflammatory bowel disease. ...
(Date:8/2/2017)... 2, 2017 Fenita J. Caldwell ... a Pinnacle Lifetime Professional in the Field of ... at Turing Pharmaceuticals, AG. Her skills and areas ... building.                ... years of experience as a highly successful sales ...
(Date:8/2/2017)... , Aug. 2, 2017  Life Flight Network and ... The agreement improves patient care and operational efficiency for patients ... Springfield , Cottage Grove , and ... medical transportation. PeaceHealth and Life Flight Network work collaboratively to ... during transport, or when a time sensitive emergency exists. ...
Breaking Medicine Technology: