Navigation Links
New stress-related gene modulates high blood pressure in mice and men
Date:11/25/2009

Does stress increase blood pressure? This simple question has been the focus of intense research for many years. New Stress-related gene Modulates High Blood Pressure in Mice & Men

Does stress increase blood pressure? This simple question has been the focus of intense research for many years. Now new research has for the first time established a link between a novel gene, phosducin, and the blood pressure response to stress in mice as well as humans. The studies were directed by scientists at the University of Freiburg and Muenster in Germany, and the Medical College of Wisconsin in Milwaukee, in collaboration with other institutions in Europe and Canada. The results are published online in the Journal of Clinical Investigation in advance of the print publication. (http://www.jci.org/articles/view/38433).

The German team, led by Lutz Hein M.D., in collaboration with Monika Stoll, Ph.D., generated mice lacking the phosducin gene and compared them with normal mice. The mice lacking this gene developed high blood pressure under various conditions of stress. The mechanism of this gene's action appears to be directly involved with specific sympathetic nerve cells The cells show a distinct increase in their activity translating into an increase in blood pressure.

The findings were then tested using DNA from 342 African Americans enrolled in an ongoing high blood pressure study at the Medical College, and 810 French Canadians at the University of Montreal. The volunteers were then asked to perform certain standardized stress-related activities which confirmed the beneficial action of the gene in humans. In African Americans as well as French Canadians, certain phosducin DNA variants serve as markers and can identify patients with an increase blood pressure response, for example when taking a math test. Additional cohorts from Europe also confirm this relationship with regard to blood pressure.

"These studies provide us with unique insights into the mechanisms of blood pressure stress response and will provide a novel target for the treatment of this distinct form of high blood pressure," says Ulrich Broeckel, M.D., associate professor of pediatrics, medicine, and physiology, and chief of pediatric genomics at the Children's Research Institute.

Dr. Broeckel conducted these studies in collaboration with Ted Kotchen, M.D., associate dean for clinical research; Allen Cowley, Ph.D., Chairman and Harry & Gertrude Hack Term Professor in Physiology; and James J. Smith and Catherine Welsch Smith Professor in Physiology; and Howard Jacob, Ph.D., Warren P. Knowles Professor in Human and Molecular Genetics and director of the Center at the Medical College. Other collaborators were Michael Harrison, graduate physiology student, as well as Dr. P. Hamet at the University of Montreal.

In an accompanying commentary, Dr. Guido Grassi, at the Clinica Medica, Italy, notes that "the approaches employed in the present study, along with the nerve traffic recording technique, represent the most sophisticated and sensitive methodologies currently available to assess neuroadrenergic function in different experimental animal models." He further emphasizes the need for additional studies to determine the therapeutic implications.


'/>"/>

Contact: Toranj Marphetia
toranj@mcw.edu
414-456-4744
Medical College of Wisconsin
Source:Eurekalert

Related medicine news :

1. Memory Formation Different in Those With Stress-Related Psychiatric Disorders
2. Stress-related disorders affect brain’s processing of memory
3. Stress-Related and Emotional Eating Can Be Curbed With the Vitamin Code(TM) Perfect Weight Formula
4. Chiropractic Can Offer Relief from Stress-Related Pain, Health Problems
5. Gene Variant Boosts Risk for Stress-Related Ischemia
6. New Science Program Teaches High School Students About Blood and Career Opportunities in the Field of Hematology
7. New Science Program Teaches High School Students About Blood and Career Opportunities in the Field of Hematology
8. Doctor-Pharmacist Teams Boost Blood Pressure Control
9. Measuring and modeling blood flow in malaria
10. High blood pressure easy to miss in children with kidney disease
11. Blood Test Could Boost Clarity of Breast MRI Results for Some
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... ... February 19, 2017 , ... ... connected home healthcare, will join forces with Healthwise ® at HIMSS ... Healthwise, the industry leader in evidence-based health education, technology and services, will demonstrate ...
(Date:2/18/2017)... ... February 17, 2017 , ... Focused start-ups, not traditional health ... according to the recent NEJM Catalyst Insights Report on the New Marketplace. ... Insights Council, a qualified group of U.S. executives, clinical leaders, and clinicians at ...
(Date:2/18/2017)... ... February 17, 2017 , ... CONTACT:, Glenn ... Beverly Hills plastic surgeon Dr. Glenn Vallecillos experiments SculpSure, the hot, ... "Traditionally, plastic surgery has been centered around that idea that to achieve ones ...
(Date:2/18/2017)... ... February 18, 2017 , ... ProParagraph Fashion Volume 2 features ... ProParagraph Fashion Volume 2 for all multi-line FCPX project needs. Great for ... and choose from hand-crafted trend-setting designs with smooth animations that will add stylistic ...
(Date:2/17/2017)... ... February 17, 2017 , ... Smiles by Seese is a ... Davidson, NC. Dr. Brian Seese leads the practice as a skilled and highly credentialed ... roof. Smiles by Seese serves patients of all ages with excellence in general, restorative, ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... , Feb. 17, 2017  Perrigo Company plc (NYSE, TASE: ... U.S. Food and Drug Administration for hydrocodone bitartrate and homatropine ... Hydrocodone bitartrate and homatropine methylbromide oral solution ... the symptomatic relief of cough in adults and children 6 ... months ending January 2017 were approximately $16 million.   ...
(Date:2/17/2017)... Feb. 17, 2017   FormFast , the leader ... new partnership with Engage , one of the ... . FormFast will serve as the forms automation ... with MEDITECH .  FormFast is ... to complement and enhance the electronic health record. FormFast,s ...
(Date:2/16/2017)... Pa. , Feb. 16, 2017 Absorption ... biologics, and medical devices, is pleased to announce that ... has been selected as a winner of the 2017 ... SmartCEO Magazine and recognizes driven executives for their ... work ethic. The awards ceremony and celebration is on ...
Breaking Medicine Technology: