Navigation Links
New strategy to attack tumor-feeding blood vessels
Date:6/6/2011

Scientists at the Walter and Eliza Hall Institute have discovered a key molecule needed to kill the blood vessels that supply tumours.

The research team from the institute's Molecular Genetics of Cancer and Cancer and Haematology divisions found that for anti-cancer therapies that target tumour blood vessels to work the death- inducing molecule Bim is required. The finding could lead to improved anti-cancer treatments that are based on a two- or three-pronged attack on both the tumour and its blood supply. The research will be published online in the Journal of Experimental Medicine today.

The growth of solid tumours, such as lung cancer, breast cancer and melanoma, depends on nutrients and oxygen being provided by the tumour blood supply. Cancer cells encourage the growth of blood vessels to feed a tumour by producing the hormone-like protein, vascular endothelial growth factor (VEGF). The research by Drs Edwina Naik, Leigh Coultas and Lorraine O'Reilly, and Professors Jerry Adams and Andreas Strasser showed that VEGF produced by tumours blocks production of Bim in the cells that line the tumour blood vessels.

New 'anti-angiogenic' medications that attack the blood vessels within tumours are showing promise in starving many types of cancers by reducing their blood supply.

In this study, in experimental melanoma, lung cancer and breast cancer models, Bim levels increased in the cells lining the blood vessels when VEGF was depleted by anti-angiogenic drugs, ultimately killing the blood vessel cells. VEGF depletion reduced the number of blood vessels in tumours, making the tumours shrink. However, in mice in which the blood vessels do not express Bim, VEGF depletion did not affect the number of tumour-associated blood vessels, and tumours grown in Bim-deficient mice did not respond to anti-angiogenic treatments.

Dr Strasser said this finding suggests that strategies for treating tumours by attacking the tu
'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Researchers develop strategy to improve patient adherence
2. Potential new strategy to reduce catheter blockage
3. A Pacman strategy to boost the immune system to fight cancer
4. Scientists devise targeted therapy strategy for rare form of childhood cancer
5. Top scientists unite to develop global scientific strategy Towards An HIV Cure
6. Protective strategy shields primate ovaries from radiation-therapy-induced damage
7. Songbirds strategy for changing its tune could inform rehab efforts
8. Memory training explored as strategy for addiction treatment
9. Selective strategy recommended for CT scans in emergency departments
10. New Drug Strategy Shows Promise Against HIV
11. UNC scientists discover potential strategy to improve cancer vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New strategy to attack tumor-feeding blood vessels
(Date:7/29/2015)... Mary, FL (PRWEB) , ... July 29, 2015 , ... ... Healthcare Providers and Systems (CAHPS) for PQRS Survey. , The CAHPS for PQRS ... In 2015, practices of 100 or more eligible providers must participate or they will ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... Pharmacy Collaborative for retail healthcare providers begins in Kissimmee, Fla. The two-day ... and physician assistants can work together to expand access to affordable, high quality ...
(Date:7/29/2015)... ... July 29, 2015 , ... VideoLink , a leading ... located in New York, NY, selected the ReadyCam on-site video studio to support ... to immediately access worldwide TV and cable news networks and participate in live ...
(Date:7/29/2015)... FL (PRWEB) , ... July 29, 2015 , ... ... have become increasingly aware of the impact drinking and substance abuse is having ... illness. Financial loss is tagged in the billions per year. [1] Will Wesch, ...
(Date:7/29/2015)... ... July 29, 2015 , ... Today the nonprofit ... Expanding Prevention through Vaccination in Older Adults, that provides a comprehensive overview of ... industry, government, and health care experts can improve patient compliance. , Although influenza, ...
Breaking Medicine News(10 mins):Health News:Avatar Solutions Approved to Administer CAHPS for Physician Quality Reporting System (PQRS) 2Health News:Avatar Solutions Approved to Administer CAHPS for Physician Quality Reporting System (PQRS) 3Health News:Last Chance for Pharmacists, Nurse Practitioners, Physician Assistants in Retail Clinics to Register for Collaborative Learning Program 2Health News:Last Chance for Pharmacists, Nurse Practitioners, Physician Assistants in Retail Clinics to Register for Collaborative Learning Program 3Health News:Last Chance for Pharmacists, Nurse Practitioners, Physician Assistants in Retail Clinics to Register for Collaborative Learning Program 4Health News:Columbia University Medical Center Installs a VideoLink ReadyCam® Video Studio on Campus; Medical Experts Able to Appear on Live TV at a Moment's Notice 2Health News:Columbia University Medical Center Installs a VideoLink ReadyCam® Video Studio on Campus; Medical Experts Able to Appear on Live TV at a Moment's Notice 3Health News:Workplace Trouble: Survey Reveals Sharp Escalation in Restaurant/Food Service Employee Drug Abuse 2Health News:Workplace Trouble: Survey Reveals Sharp Escalation in Restaurant/Food Service Employee Drug Abuse 3Health News:Vaccination Rates in Older Adults Fall Short of Targets 2Health News:Vaccination Rates in Older Adults Fall Short of Targets 3
... ... County ,” Dr. Milind Ambe consulted with Lynne Curtin’s teen-age daughter about cosmetic surgery. ... with the 19 year-old. , ... (Vocus) December 29, 2009 -- Newport Beach plastic surgeon, Dr. Milind Ambe, ...
... With ... the silver screen’s ageless face has on mainstream America. , ... Anaheim, Calif. (PRWEB) December 29, 2009 -- ... Gugino, an actress of Night at the Museum, Race to Witch Mountain, and American ...
... Origins Recovery ... expanded its’ continuum of care with the addition of Origins Sober Living Facilities in major ... Dallas, Texas ... its’ continuum of care to include Origins owned and operated sober living facilities in select ...
... ... Health Care Act , ... the over 2000 pages contained within HR 3200, the House Bill that the recently passed ... for Americans thanks to a cooperative effort between Hearthebill.org and iScroll , developers of ...
... Urges All Pennsylvanians to Get Vaccinated , HARRISBURG, Pa., Dec. ... or CDC, has allocated a total of 4,003,100 doses of ... of Health said today. , The vaccine has been ... health centers. , The Department of Health will ...
... With the New Year just around the corner, people are ... Lose weight., Exercise more., ... Year,s resolutions is health-related, many tend to forget about the basics ... more so, we forgo the regular visits to the dentist. , ...
Cached Medicine News:Health News:Newport Beach Plastic Surgeon Educates About the Pros and Cons of Plastic Surgery 2Health News:Newport Beach Plastic Surgeon Educates About the Pros and Cons of Plastic Surgery 3Health News:Dermatologists Dissect Hollywood's Ageless Face Obsession 2Health News:Origins Recovery Centers Announces an Expansion of its Continuum of Care 2Health News:Origins Recovery Centers Announces an Expansion of its Continuum of Care 3Health News:House Health Care Bill Becomes Up To 38% More Understandable 2Health News:Celebrate the New Year With a New You 2
(Date:7/29/2015)... , July 29, 2015  Depomed, Inc. (NASDAQ: ... that its Board of Directors, after careful consideration ... and legal advisors, has unanimously rejected the purported ... Horizon Pharma plc (NASDAQ: HZNP ) ("Horizon") ... Depomed in an all-stock transaction (the "July 21 ...
(Date:7/29/2015)... 29, 2015 The U.S. Food and Drug ... the ReShape Integrated Dual Balloon System, that may help ... people with obesity and one or more obesity-related conditions, ... Surgery (ASMBS), the nation,s largest organization for bariatric surgeons. ... careful review the FDA has approved this new device ...
(Date:7/29/2015)... SAN DIEGO and WALTHAM, Mass., July 29, ... LLP is investigating whether certain officers ... breached their fiduciary duties to shareholders.  AMAG Pharmaceuticals ... on maternal health, anemia, and cancer supportive care.  ... to reduce the risk of preterm birth in ...
Breaking Medicine Technology:Depomed's Board of Directors Unanimously Rejects Purported Revised, Highly Conditional, Unsolicited Proposal from Horizon Pharma plc 2Depomed's Board of Directors Unanimously Rejects Purported Revised, Highly Conditional, Unsolicited Proposal from Horizon Pharma plc 3Depomed's Board of Directors Unanimously Rejects Purported Revised, Highly Conditional, Unsolicited Proposal from Horizon Pharma plc 4Depomed's Board of Directors Unanimously Rejects Purported Revised, Highly Conditional, Unsolicited Proposal from Horizon Pharma plc 5Depomed's Board of Directors Unanimously Rejects Purported Revised, Highly Conditional, Unsolicited Proposal from Horizon Pharma plc 6Depomed's Board of Directors Unanimously Rejects Purported Revised, Highly Conditional, Unsolicited Proposal from Horizon Pharma plc 7Depomed's Board of Directors Unanimously Rejects Purported Revised, Highly Conditional, Unsolicited Proposal from Horizon Pharma plc 8Depomed's Board of Directors Unanimously Rejects Purported Revised, Highly Conditional, Unsolicited Proposal from Horizon Pharma plc 9American Society for Metabolic and Bariatric Surgery Views New Balloon Device For Obesity As Bridge Between Medications And Bariatric Surgery 2American Society for Metabolic and Bariatric Surgery Views New Balloon Device For Obesity As Bridge Between Medications And Bariatric Surgery 3Robbins Arroyo LLP Is Investigating the Officers and Directors of AMAG Pharmaceuticals, Inc. (AMAG) on Behalf of Shareholders 2
... 2011 /PRNewswire-Asia-FirstCall/ -- 3SBio Inc. (NASDAQ: ... biotechnology company focused on researching, developing, manufacturing and ... general meeting of shareholders of 3SBio Inc. will ... a.m., Shenyang time, at our executive office, 15/A-D, ...
... U.S. Food and Drug Administration today approved Adcetris (brentuximab ... lymphoma known as systemic anaplastic large cell lymphoma (ALCL). ... cancers of the lymphatic system. Adcetris is an antibody-drug ... antibody to direct the drug to a target on ...
Cached Medicine Technology:3SBio Inc. to Hold 2011 Annual General Meeting on September 20, 2011 2FDA Approves Adcetris to Treat Two Types of Lymphoma 2FDA Approves Adcetris to Treat Two Types of Lymphoma 3
... temperature set by means of a ... button. A green LED indicates the ... amber LED indicates the unit has ... LED and an audible alarm indicates ...
Provides outstanding patient warming and safety throughout the hospital and is nearly half the size and one-third the weight of earlier units....
The QuickVue Advance® G. vaginalis test is an enzyme activity test for use in the detection of Gardnerella vaginalis Proline IminoPeptidase(PIP) activity in vaginal fluid specimens from women su...
The Affirm™ VPIII tests RNA probe technology offers a dependable, rapid means toward early identification and treatment of patients suffering from these pathogens....
Medicine Products: