Navigation Links
New strategies to improve treatment and ultimately prevent heart failure in children
Date:7/7/2009

INDIANAPOLIS Structural cardiovascular abnormalities present at birth are the leading cause of heart failure in children. Nearly half a million children in the United States have structural heart problems ranging in severity from relatively simple issues, such as small holes between chambers of the heart, to very severe malformations, including complete absence of one or more chambers or valves.

The July issue of the journal Pediatric Cardiology focuses on a recent meeting of pediatric cardiology experts from around the world who gathered at the Indiana University School of Medicine and Riley Hospital for Children for the inaugural Riley Heart Center Symposium on Cardiac Development. The experts presented new basic science and clinical research to improve treatment of, and ultimately to prevent, the congenital defects and damage acquired after birth that cause heart failure in children.

The symposium focused on the growth of the ventricular wall in development and disease, and on the diagnosis and treatment of non-compaction of the left ventricle - an abnormality of the major pumping chamber of the heart which often leads to heart failure. Both are areas of ongoing study by the Riley Heart Research Center.

"A wide spectrum of congenital and acquired cardiac injuries can give rise to childhood heart failure. To advance our ability to treat heart failure in children, it is of critical importance to develop an understanding of the cellular and molecular mechanisms underlying the genesis of congenital heart defects, and to develop an understanding of the molecular processes that negatively impact upon heart muscle cell function and survival during the progression of childhood heart failure," wrote symposium organizer Loren Field, Ph.D., professor of medicine, and pediatrics, who directs the Riley Heart Research Center and convened the symposium. The Riley Heart Research Center is located in the Herman B Wells Center for Pediatric Research in the Department of Pediatrics at the IU School of Medicine and Riley Hospital.

Although there are fewer children than adults with this serious and sometimes fatal condition, the societal issues and health-care costs of heart failure, are more significant in young patients given the longer lifespan of children.

Growth of the heart during development is characterized by the differentiation and proliferation of beating cardiac muscle cells. After birth there is a transition which limits the ability of the heart to regenerate itself following injury or disease. In his presentation and paper, Dr. Field described the innovative cell cycle-based strategies he employs in the laboratory to stimulate heart muscle tissue to repair itself resulting in regeneration of damaged tissue.

Designing and testing genetically engineered mice, Weinian Shou, Ph.D., associate professor of pediatrics, reported that he and colleagues are gaining a greater understanding of the molecular and genetic mechanisms of noncompaction of the left ventricle, with the ultimate goal of finding potential new therapies.

In a study designed to evaluate the outcomes of children with noncompaction of the left ventricle, Eric Ebenroth, M.D., associate clinical professor of pediatrics, followed 46 Riley Hospital patients with this type of heart failure. He found that when the disease presents before the child reaches his first birthday, the child has a much lower chance for survival. Dr. Ebenroth and colleagues now are working to identify additional risk factors associated with the increased likelihood of death in these patients in the hopes of improving their outcomes.

"It is hoped that these proceedings, as well as those from future Riley Heart Center Symposia, will foster collaborative projects between clinical and basic researchers who are dedicated to improving the treatment, and ultimately preventing the onset, of heart failure in the young," said Dr. Field.


'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University
Source:Eurekalert

Related medicine news :

1. Health Care Reform May Force U.S. Pharmaceutical Companies to Overhaul Sales Strategies, Says New Report From ZS Associates and eyeforpharma
2. As college drinking problems rise, new studies identify effective prevention strategies
3. Johnson & Johnson Highlights Pharmaceutical Growth Strategies and Robust Pipeline to Address Unmet Medical Needs
4. Computer modeling shows strategies to rein in epidemics need to be retooled for rural populations
5. Strategies to Rein in Epidemics Need to be Retooled for Rural Populations, Say K-State Engineers Using Computers to Model Disease Outbreaks in Rural Areas
6. BurrellesLuce Sponsoring Track on 'Advanced PR Strategies' At Annual Industry Summit to Be Held May 17-19 in New York
7. AUDIO from Medialink and the Alzheimers Foundation of America: Strategies for Healthy Aging
8. GAA Applauds Global Funds Decision to Accelerate Support for Treatment Strategies to Prevent Mother-to-Child Transmission of HIV
9. Alzheimers Foundation of America Lays Out Strategies for Healthy Aging
10. The Road to Career Success and Happiness: New Book Offers Practical Strategies for Achieving Desired Results in Work and Life
11. Quality of life may impact coping strategies of young women with breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... ... May 28, 2016 , ... SuperCloset is proud to officially ... the day to day issues, struggles and obstacles veterans’ need to overcome in order ... Project provides active or retired military veteran(s) with a donated SuperCloset product based on ...
(Date:5/28/2016)... ... ... year and a half of planning the Multiple Pathways of Recovery Conference , CCAR ... Conference was held May 2 -4, 2016 at the Mystic Marriott Hotel & Spa ... the many pathways individuals use to get into and sustain their recovery. Pathways of ...
(Date:5/27/2016)... ... May 27, 2016 , ... Southland Log Homes , designer ... timber frame barn kits, which can be found on its website at SouthlandLogHomes.com. , ... barn plans, and they highlight the craftsmanship of timber post and beam construction. ...
(Date:5/27/2016)... ... May 27, 2016 , ... An influential resource amongst nurses and professionals in ... lights on the variety of topics detailing why we appreciate nurses in so many ... career has gone from being in a major recession to one of the hottest ...
(Date:5/27/2016)... ... May 27, 2016 , ... An educational campaign aimed at ... stories, courtesy of awareness-driven celebrities and thought leaders. It also provides insight to ... industry leaders such as Bioness. , As patients feel increasingly concerned about ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 Inivata, ... precision of circulating tumour DNA (ctDNA) analysis to ... appointment of Professor Clive Morris as ... across the clinical development programme, scientific collaborations, and ... deliver significant improvements in clinical outcomes for patients. ...
(Date:5/24/2016)... -- Niederländische Chirurgen haben eine innovative ... erlaubt, ihre Expertise weltweit zu teilen und so ... mit einer Instant-Messaging-Funktion und der Möglichkeit, in einem ... Afrika, Asien und den USA ... Information und Weiterbildung   "MDLinking ...
(Date:5/24/2016)... LONDON , May 24, 2016 ... erfüllt beide primären Endpunkte ... und Überlegenheit in ‚ausgezeichneter plus guter ... aufsteigenden Colons    ,      (Logo: ... B.V. gab heute neue positive Daten von der ...
Breaking Medicine Technology: