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New stem cell research could aid in battle against bulging waistlines
Date:6/16/2011

on."

The researchers report that delta-decorin, a modification of a previously defined protein, interacts with another clinically important protein called resistin on the surface of adipose stem cells. "The decorin-resistin connection is particularly interesting because both decorin and resistin have been previously implicated in Type-2 diabetes and other inflammation-related disease," Kolonin said.

"The next step will involve preclinical tests to see if we can develop the identified peptide into compounds that target these adipose stem cells," Kolonin said. "By depleting the adipose tissue progenitors, we may be able to provide long-term control of white fat."

Kolonin believes this approach could complement an anti-obesity compound he developed at The University of Texas MD Anderson Cancer Center before joining the UTHealth faculty. The compound called "Adipotide" works by targeting the blood vessels in fat and is licensed to Ablaris Therapeutics, Inc.

"Helping people lose weight might also reduce their risk of cardiovascular diseases, certain types of cancer, Type 2 diabetes and other obesity-related diseases," said Kolonin. Previous studies in Kolonin's laboratory have demonstrated the role of adipose stem cells in cancer progression.


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Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert  

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