Navigation Links
New stem cell research, transplant strategies show promise to improve outcomes, reduce complications
Date:12/9/2012

ation (HSCT) may safely reduce the incidence and severity of a challenging complication called graft-versus-host disease (GVHD).

HSCT is the primary form of treatment for many patients with blood disorders; it involves the transplantation of healthy blood-forming stem cells from the bone marrow, circulating blood, or umbilical cord blood to replace damaged, disease-causing cells in recipients. Despite the therapeutic benefits of HSCT, half of all patients who receive transplants from a related donor (allogeneic HCT) develop acute GVHD, a life-threatening condition occurring when the newly transplanted cells identify the recipient's body as foreign and attack the recipient's own cells.

Currently, HSCT patients receive prophylactic therapy before and after transplant to prepare their bodies for the procedure and to help manage their subsequent immune response. While this series of drugs is designed to help reduce patients' risk of developing GVHD, it also compromises their immune systems, leaving them vulnerable to serious infections and complications. Recent research has sought to determine ways to improve patients' initial immune response to transplanted cells as well as promote faster immune recovery after transplant.

Recent early-stage studies have demonstrated that a class of anti-cancer drugs known as histone deacetylase inhibitors (HDACi) may safely reduce the risk of GVHD in patients. These drugs have demonstrated an ability to "turn off" an enzyme that leads to inflammation, a major contributor to GVHD that develops as a byproduct of patients' intense immune response to HSCT. Based on those early results, researchers initiated the current study to evaluate whether one drug in this class, vorinostat, might reduce the risk of acute GVHD when added to current regimens.

To test this hypothesis, researchers enrolled 45 patients undergoing matched related donor HSCT from transplant centers at the University of Michigan in An
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Networks it takes a village approach improves dementia care and informs research, study shows
2. Doctors Biased Against Drug Company Research, Study Finds
3. US risks losing out to Asia in medical research, U-M team warns
4. Deadly outbreak of West Nile virus highlights urgent need for more research, funding
5. Clinical trials start for stroke drug developed by Scripps Research, USC, and ZZ Biotech
6. Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
7. NYU Langone experts present research, clinical advances at neurosurgeons meeting
8. Aging hepatitis C population escalates demand for liver transplantation
9. Rejected hearts now viable for transplantation after stress echo
10. University of Cincinnati leads first trial on steroid and CNI withdrawal post-transplant
11. Brain cell transplants in early 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... July 30, 2015 , ... The ... BioPharma, Inc. are pleased to announce that data standards for clinical research in ... on the CDISC website . These three Therapeutic Area (TA) standards were ...
(Date:7/30/2015)... ... July 30, 2015 , ... In an effort to provide ... Aggarwal is making a change in his practice. , The decision will also allow ... 2015, Dr. Aggarwal will be transferring his in-patient admissions to the hospitalists at East ...
(Date:7/30/2015)... ... July 30, 2015 , ... Women's dating ... Lines ." It's for women interested in improving their love lives using specific ... which officially launched to the public early this morning, has drawn praise from ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... In a ... clients at Serenity Palms Drug Addiction Treatment Center have created an addiction graveyard. Sharing ... one of its most beloved residents, Rocky Hudson . Hudson (1945-2015) fell in ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... is the recipient of three awards in the Service Industry Advertising Awards 12th ... for Choptank Transport, KRM Development Corporation and University of Maryland Shore Regional Health. ...
Breaking Medicine News(10 mins):Health News:CDISC Releases Clinical Research Data Standards for Schizophrenia, Hepatitis C and Dyslipidemia 2Health News:CDISC Releases Clinical Research Data Standards for Schizophrenia, Hepatitis C and Dyslipidemia 3Health News:CDISC Releases Clinical Research Data Standards for Schizophrenia, Hepatitis C and Dyslipidemia 4Health News:CDISC Releases Clinical Research Data Standards for Schizophrenia, Hepatitis C and Dyslipidemia 5Health News:River Valley Physician Dr. Aggarwal is Making Changes to his Practice 2Health News:Lovetraction Lines - Review Examining Simone Myers' New Online Course Released 2Health News:Serenity Palms Honors Rocky Hudson, an Advocate of AA and a Beloved Resident of Palm Springs 2Health News:Serenity Palms Honors Rocky Hudson, an Advocate of AA and a Beloved Resident of Palm Springs 3Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 2Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 3
... the all-natural weight management program, opened in Ottawa with the ... began their weight-loss journey on the Smart for Life(TM) program ... for 6 family members. As friends and relatives joined the ... exciting business opportunity. , "Smart for Life(TM) is ...
... and services company focused on global eClinical solutions for the clinical ... studies from European Sponsor clients. These new studies will seek to ... as the Indian subcontinent. , "We ... to be a direct result of our continued hard work in ...
... ... and CEO of Abraxis Health, will receive the Adaptive Business Leaders Organization,s 2009 ... Awards Event on October 28, in Newport Beach. , ... Santa Ana, CA (PRWEB) October ...
... ... launch of their "Tats for Tatas" fundraising campaign that will take place ... the company,s concerted efforts to raise awareness and funds for Breast Cancer ... the company will be donating 10% of all proceeds from sales throughout ...
... Pa., Oct. 15 Herley Industries, Inc. (Nasdaq: HRLY ... Fiscal Year ended August 2, 2009. , Fourth Quarter ... quarter of fiscal 2009 were $43.0 million compared to $37.9 ... fourth quarter of fiscal 2009, the Company recorded several significant ...
... Minnesota Nurses Point to Benefits for Patients, Nurse Staffing and ... A new Senate bill introduced today by Sen. Al ... of RNs in hospitals and other health care facilities, but ... transported and moved in the safest way possible, all while ...
Cached Medicine News:Health News:Smart for Life(TM) Center Opens in Ottawa 2Health News:DATATRAK Announces the Award of New Studies from European Pharmaceutical Clients 2Health News:DATATRAK Announces the Award of New Studies from European Pharmaceutical Clients 3Health News:Patrick Soon-Shiong, World Renowned Healthcare Visionary & Philanthropist, to Receive ABL's Leadership Award & Make Keynote Presentation, October 28, in Newport Beach 2Health News:Patrick Soon-Shiong, World Renowned Healthcare Visionary & Philanthropist, to Receive ABL's Leadership Award & Make Keynote Presentation, October 28, in Newport Beach 3Health News:Patrick Soon-Shiong, World Renowned Healthcare Visionary & Philanthropist, to Receive ABL's Leadership Award & Make Keynote Presentation, October 28, in Newport Beach 4Health News:Atomic Tattoos Announces "Tats for Tatas" October Fundraising Event to Benefit Local Breast Cancer Research 2Health News:Herley Reports Fourth Quarter and Year-End Results 2Health News:Herley Reports Fourth Quarter and Year-End Results 3Health News:Herley Reports Fourth Quarter and Year-End Results 4Health News:Herley Reports Fourth Quarter and Year-End Results 5Health News:Herley Reports Fourth Quarter and Year-End Results 6Health News:Herley Reports Fourth Quarter and Year-End Results 7Health News:Herley Reports Fourth Quarter and Year-End Results 8Health News:Herley Reports Fourth Quarter and Year-End Results 9Health News:Herley Reports Fourth Quarter and Year-End Results 10Health News:Herley Reports Fourth Quarter and Year-End Results 11Health News:Herley Reports Fourth Quarter and Year-End Results 12Health News:Nation's RNs Hail Sen. Franken's Support for Safe Patient Handling Measure 2
(Date:7/30/2015)... SAN DIEGO , July 30, 2015 ... announced it has signed a definitive agreement ... provider of non-invasive ventilation and sleep-disordered breathing ... strong clinical, innovation and market reputation in China, combined with ResMed,s global leadership ... of people in China ...
(Date:7/30/2015)... 2015  EP Global Communications, Inc. (Public OTC: EPGL) announced ... the Company about discussing EPGL,s electronic contact lens ... August 3, 2015.  Novartis CEO Joe Jimenez ... coming electronic contact lens market could be worth ... several years.  Novartis partnered with Google in 2014 ...
(Date:7/30/2015)... 30, 2015  Amgen (NASDAQ: AMGN ) ... of 2015. Key results include: , Total ... of 2014 to $5,370 million, with 6 percent ... (etanercept), Prolia ® (denosumab), Sensipar ® ... ® (denosumab). Unfavorable changes in foreign exchange ...
Breaking Medicine Technology:ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 2Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 4Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 5Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 6Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 7Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 8Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 9Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 10Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 11Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 12Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 13Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 14Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 15Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 16Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 17Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 18Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 19Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 20Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 21Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 22Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 23
... Calif., Feb. 25, 2011 Accuray Incorporated ... the field of radiosurgery, announced today that its Senior Vice ... was named "Best General Counsel, Small Public Company" by the ... San Francisco Business Times as part of their ,Best ...
... Landauer, Inc. (NYSE: LDR ) announced today that ... $0.55 per share for the second quarter of fiscal 2011.  The ... record on March 11, 2011. About Landauer ... analytical services to determine occupational and environmental radiation exposure and is ...
Cached Medicine Technology:Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 2Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 3Accuray's General Counsel Wins Best Bay Area Corporate Counsel Award 4
... opticians in a store environment. Optizone ... retail store industry by opticians. Optizone ... for Optizone 2000. It is written ... User friendly screen interfaces make learning ...
This product offers patient, product and practice cash management to ease the strain of practice administration....
... MaximEyes by First Insight is the ... records solution for eye care professionals. ... with Eyefinitys online servicesrequest VSP authorizations, ... MaximEyes offers EMR, scheduling, billing, demographics, ...
... software for eyecare professionals- Winx ... multi-office practice management system, using ... Winx Pro is a complete ... in effectively managing the administrative, ...
Medicine Products: