Navigation Links
New stem cell research, transplant strategies show promise to improve outcomes, reduce complications
Date:12/9/2012

ation (HSCT) may safely reduce the incidence and severity of a challenging complication called graft-versus-host disease (GVHD).

HSCT is the primary form of treatment for many patients with blood disorders; it involves the transplantation of healthy blood-forming stem cells from the bone marrow, circulating blood, or umbilical cord blood to replace damaged, disease-causing cells in recipients. Despite the therapeutic benefits of HSCT, half of all patients who receive transplants from a related donor (allogeneic HCT) develop acute GVHD, a life-threatening condition occurring when the newly transplanted cells identify the recipient's body as foreign and attack the recipient's own cells.

Currently, HSCT patients receive prophylactic therapy before and after transplant to prepare their bodies for the procedure and to help manage their subsequent immune response. While this series of drugs is designed to help reduce patients' risk of developing GVHD, it also compromises their immune systems, leaving them vulnerable to serious infections and complications. Recent research has sought to determine ways to improve patients' initial immune response to transplanted cells as well as promote faster immune recovery after transplant.

Recent early-stage studies have demonstrated that a class of anti-cancer drugs known as histone deacetylase inhibitors (HDACi) may safely reduce the risk of GVHD in patients. These drugs have demonstrated an ability to "turn off" an enzyme that leads to inflammation, a major contributor to GVHD that develops as a byproduct of patients' intense immune response to HSCT. Based on those early results, researchers initiated the current study to evaluate whether one drug in this class, vorinostat, might reduce the risk of acute GVHD when added to current regimens.

To test this hypothesis, researchers enrolled 45 patients undergoing matched related donor HSCT from transplant centers at the University of Michigan in An
'/>"/>

Contact: Andrea Slesinski
aslesinski@hematology.org
614-352-5096
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Networks it takes a village approach improves dementia care and informs research, study shows
2. Doctors Biased Against Drug Company Research, Study Finds
3. US risks losing out to Asia in medical research, U-M team warns
4. Deadly outbreak of West Nile virus highlights urgent need for more research, funding
5. Clinical trials start for stroke drug developed by Scripps Research, USC, and ZZ Biotech
6. Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO
7. NYU Langone experts present research, clinical advances at neurosurgeons meeting
8. Aging hepatitis C population escalates demand for liver transplantation
9. Rejected hearts now viable for transplantation after stress echo
10. University of Cincinnati leads first trial on steroid and CNI withdrawal post-transplant
11. Brain cell transplants in early 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Daily Gossip writes in its Xtreme Fat ... the fastest fat loss program ever developed. It promises to ... , There is no wonder after all that this has ... The new nutrition and workout fat loss program was created ... , According to the author of this fat loss system, ...
(Date:10/31/2014)... 2014 This Method to get ... effects for practitioners. , The Hypopresive (aka ... Science and Movement specializing in physical rehabilitation. Dr. ... floor reeducation that traditional abdominal exercises after pregnancy ... Prolepses, etc. , The Hipopressives exercises pull back ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 With all ... one Midwest optometrist feels they may overlook one critical ... affect areas like concentration, school performance and even behavior. ... too brief to identify progressive vision problems, and to ... Mo., announces a new initiative: The Awesome Eyes Student ...
(Date:10/31/2014)... FL (PRWEB) October 31, 2014 Energy ... compression gear. The new gear is now available online, ... on the benefits of Celliant infrared-active athletic gear over ... reported that another contract has been signed for Under ... speedskaters for the next eight years. In light of ...
(Date:10/31/2014)... Oct. 31, 2014 (HealthDay News) -- Sleep apnea may make ... where you parked your car or left your house keys, ... severe sleep apnea showed that this ability -- called spatial ... movement (REM) sleep, even when other stages of sleep weren,t ... which dreams typically occur. "We,ve shown for the first ...
Breaking Medicine News(10 mins):Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 3Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Sleep Apnea May Steal Some of Your Memory: Study 2
... 16 In this tough economy many,Americans are losing ... looking,at alternative health insurance options. Not only ... for most individuals and families, the loss of,health care ... the mortgage and,banking crisis, medical bills remain the leading ...
... Medical,International Limited (NYSE: MR ), a leading ... that it will present at,the 27th Annual J.P. Morgan ... The conference will ... Ronald Ede, Group Vice President of International,Operations and May ...
... can no longer be ignored. Treadmill desks offer a unique solution that ... ... America,s fixation on low carb diets has been shown to be ineffective ... it may have harmful effects on brain function as well. The study ...
... the unrivaled success of the diabetes pill DBCare®, Healing Power has ... alleviate physical and mental ailments such as blood pressure, allergies and ... ... December 16, 2008 - Healing Power Inc., a leader in all-natural ...
... large, multicenter clinical trial has shown that a diet ... in fat compared to standard federal dietary recommendations cuts ... breast cancer survivors women who didn,t have hot ... have higher recurrence and lower survival rates than breast ...
... Dec. 15 /PRNewswire-FirstCall/ - Labopharm Inc. (TSX: DDS; NASDAQ: ... on, Tuesday, December 16, 2008, at 10:00 am (ET) ... the product profile, clinical and regulatory progress and the ... (DDS-04A), a serotonin antagonist reuptake inhibitor (SARI), for the ...
Cached Medicine News:Health News:HealthInsuranceFinders.com Publishes Health Insurance Guide for the Recently Unemployed 2Health News:HealthInsuranceFinders.com Publishes Health Insurance Guide for the Recently Unemployed 3Health News:HealthInsuranceFinders.com Publishes Health Insurance Guide for the Recently Unemployed 4Health News:Mindray Medical to Present at the 27th Annual J.P. Morgan Healthcare Conference 2Health News:Low Carb Diets Shown to Impair Cognitive Function, Treadmill Desks Improve It 2Health News:Low Carb Diets Shown to Impair Cognitive Function, Treadmill Desks Improve It 3Health News:Healing Power Inc. Introduces New Web Site with 14 New Ayurvedic Products to Promote a Healthier Life 2Health News:Healing Power Inc. Introduces New Web Site with 14 New Ayurvedic Products to Promote a Healthier Life 3Health News:Diet may cut risk of breast cancer recurrence in women without hot flashes 2Health News:Diet may cut risk of breast cancer recurrence in women without hot flashes 3Health News:Labopharm to host webcast presentation on novel trazodone formulation - tomorrow (Dec.16/08) at 10:00 a.m. ET 2Health News:Labopharm to host webcast presentation on novel trazodone formulation - tomorrow (Dec.16/08) at 10:00 a.m. ET 3Health News:Labopharm to host webcast presentation on novel trazodone formulation - tomorrow (Dec.16/08) at 10:00 a.m. ET 4
(Date:10/31/2014)... 30, 2014 Migranade, Inc. announced today the ... to the 36 million U.S. migraine sufferers November, 2014. ... targets the actual cause of migraines and not just ... not the source Migranade is assured to be a ... Relief is available at http://www.migranade.com and will ...
(Date:10/31/2014)... 31, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ... , Isis Pharmaceuticals, Third Quarter 2014 Financial Results ... at 11:30 a.m. ET / 8:30 a.m. PTWhere: ... Internet. Simply log onto our website listed above. If ... a replay of the webcast will be available for ...
(Date:10/30/2014)... CHARLOTTETOWN , Oct. 30, 2014 /CNW/ - Atlantic ... three-year agreement reached between Canada,s ... Jim Keon , President of the Canadian Generic Pharmaceutical ... made the comments while speaking at the Atlantic Summit ... Charlottetown , which is being hosted by the ...
Breaking Medicine Technology:Game Changing Migraine Medication To Be Available November 2014 2Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 2Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 3Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 3
... N.J., Aug. 1, 2011 Social stigma is the ... care physicians, according to a survey commissioned by Janssen ... the National Medical Association (NMA).(1) Despite the belief by ... very serious or a crisis in the African-American community, ...
... Reportlinker.com announces that a new market research ... Prefilled Syringes: Devices, Therapeutics, Players, ... http://www.reportlinker.com/p0581168/Prefilled-Syringes-Devices-Therapeutics-Players-Markets-and-Prospects .html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... continues to grow, the issue of prefilled ...
Cached Medicine Technology:Stigma Remains a Significant Barrier to Routine HIV Testing by African-American Physicians, Survey Finds 2Stigma Remains a Significant Barrier to Routine HIV Testing by African-American Physicians, Survey Finds 3Stigma Remains a Significant Barrier to Routine HIV Testing by African-American Physicians, Survey Finds 4Prefilled Syringes: Devices, Therapeutics, Players, Markets and Prospects 2Prefilled Syringes: Devices, Therapeutics, Players, Markets and Prospects 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: