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New statistical method offers automatic mitotic cell detection for cancer diagnosis
Date:11/12/2012

step which is critical to the accuracy of mitotic cell detection.

Secondly it statistically models the intensity distribution of mitotic and non-mitotic cells in tumour areas, ignoring the non-tumorous areas. This step therefore identifies potential mitotic cells in tumour areas.

Finally the method looks at the surrounding architecture of these potential mitotic cell candidates in order to confirm them as mitotic cells, thereby reducing the number of possible false alarms.

Although there are algorithms in existence which provide automation in some parts of the mitotic cell detection process, the method developed at Warwick is the first to offer a comprehensive solution addressing the entire process.

The method is outlined in a study focusing on breast cancer histology images presented at a major conference on the subject.

Although the research to date has centred on breast cancer histology images, the scientists believe the method can be applied to other types of cancer.

In a pilot study, the method has been successfully tested against two expert pathologists' identification of the mitotic cells. Larger scale trials are currently under way and a patent application has been filed. The researchers are also keen to collaborate with industrial partners.


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Contact: Anna Blackaby
44-024-765-75910
University of Warwick
Source:Eurekalert

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