Navigation Links
New statistical method offers automatic mitotic cell detection for cancer diagnosis
Date:11/12/2012

Scientists have developed a statistical image analysis method which can assist in the grading of breast cancer by automatically segmenting tumour regions and detecting dividing cells in tissue samples.

The system, developed at the University of Warwick, promises to bring objectivity and automation to the cancer grading process which is used to determine the aggressiveness of the treatment offered to the patient.

Number of mitotic cells, cells which are dividing to create new cells, is a key indicator used by histopathologists for diagnosing and grading cancer.

At present the dominant system in the UK and much of the world the Nottingham Grading System - is based on expert analysis of tissue samples to determine the severity of the cancer.

As a subjective system dependent on visual analysis, it can produce substantial variability in diagnostic assessment, resulting in low agreement between pathologists.

A pilot study conducted by researchers at Warwick found there to be an agreement of 19 per cent between three pathologists in identifying the mitotic cells.

In response to the need for more objectivity, a team at the University of Warwick have developed a three-step method which takes an image of tissue samples and applies statistical modelling to detect mitotic cells in that image.

Dr Nasir Rajpoot from the Department of Computer Science at the University of Warwick said: "It has long been recognised that there is a need to increase objectivity in the cancer grading process.

"This grading process determines the treatment offered to people who have been diagnosed with cancer, so it's vital to get it right in order to prevent patients undergoing unnecessarily aggressive treatments.

"We believe our method takes a significant step towards this by offering an objective, automatic technique to assist the pathologists in grading of breast cancer."

The method consists of three key steps. Firstly it segments the tumour margins, a step which is critical to the accuracy of mitotic cell detection.

Secondly it statistically models the intensity distribution of mitotic and non-mitotic cells in tumour areas, ignoring the non-tumorous areas. This step therefore identifies potential mitotic cells in tumour areas.

Finally the method looks at the surrounding architecture of these potential mitotic cell candidates in order to confirm them as mitotic cells, thereby reducing the number of possible false alarms.

Although there are algorithms in existence which provide automation in some parts of the mitotic cell detection process, the method developed at Warwick is the first to offer a comprehensive solution addressing the entire process.

The method is outlined in a study focusing on breast cancer histology images presented at a major conference on the subject.

Although the research to date has centred on breast cancer histology images, the scientists believe the method can be applied to other types of cancer.

In a pilot study, the method has been successfully tested against two expert pathologists' identification of the mitotic cells. Larger scale trials are currently under way and a patent application has been filed. The researchers are also keen to collaborate with industrial partners.


'/>"/>

Contact: Anna Blackaby
44-024-765-75910
University of Warwick
Source:Eurekalert

Related medicine news :

1. Nonsurgical Method to Measure Brain Pressure Shows Promise
2. New Method to Reveal Alzheimers Marker Shows Promise
3. New method to measure work addiction
4. Advanced genetic screening method may speed vaccine development
5. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
6. Hear to see: New method for the treatment of visual field defects
7. Safer Grilling Methods Might Cut Cancer Risk
8. Quick-Reversal Method May Be at Hand for New Blood Thinner
9. New delivery method improves efficacy of 2 common Parkinsons disease medications
10. Electronic data methods research seeks to build a learning health care system
11. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for giving! Today, 20 creative ... National Family Partnership and the Drug Enforcement Administration as part of the National Red ... 10 winning schools who decorated their campuses with this year’s Red Ribbon Week theme: ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... they now offer a comprehensive in-house dental plan for all patients. Understanding that ... a plan that gives patients a number of perks, including discounts on many ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... Deloitte Wisconsin 75, an annual ranking and recognition of the largest closely held ... list, having ranked from 2008-2016. In addition, Standard Process was awarded the Talent ...
(Date:11/30/2016)... ... November 30, 2016 , ... Center For ... announced the opening of a new residential mental health treatment program in Chino ... issues such as severe anxiety, depression, bi-polar disorder, and other related issues. , ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... and stylish design wanted by today’s consumers at an affordable price, is now ... says the new watch is “a game changer” when it comes to the ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... bioLytical Laboratories, ein Weltführer bei schnellen Tests für ... Apothekenbundes von Kenia eingeführt. Continue Reading ... ... Test! (PRNewsFoto/bioLytical Laboratories) ... http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical wurde durch die ...
(Date:12/2/2016)... , December 2, 2016 Orthopedic Implants ... Support) is Expected to Gain a Significant Market Share Owing ... Ailments  ... According to a new ... Medical Implants Sterile Packaging: Clamshell Product Type Segment Projected to ...
(Date:12/2/2016)... December 2, 2016 On Thursday, the ... in red, while the Dow Jones Industrial Average managed to ... of US markets, which prompted Stock-callers this morning to look ... (NASDAQ: NUVA ), Smith & Nephew PLC (NYSE: ... NXTM ), and Cesca Therapeutics Inc. (NASDAQ: KOOL ...
Breaking Medicine Technology: