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New standards of care and novel treatment options for several forms of lymphoma unveiled
Date:12/6/2010

of 1,655 patients with early, unfavorable stages of Hodgkin lymphoma were randomized to one of two treatment arms. In the control arm, 818 patients received four cycles of ABVD chemotherapy. In the experimental arm, 805 patients received two cycles of an escalated dose of BEACOPP chemotherapy followed by two cycles of ABVD chemotherapy. Following the chemotherapy regimens, all patients received 30 Gy IF-RT.

After a median follow-up of 42.4 months (about 3.5 years), the estimated four-year freedom from treatment failure rate was significantly higher in the BEACOPP arm as compared with the control arm (94.7 percent and 89.3 percent, respectively). The overall response rate to treatment was 95 percent in each arm of the study. No significant difference in overall survival has been seen yet.

"Results from this study demonstrate that an early intensification treatment approach with an escalated regimen of BEACOPP chemotherapy results in better overall tumor control in patients with early, unfavorable Hodgkin lymphoma," said lead study author Andreas Engert, MD, Chairman, German Hodgkin Study Group, University Hospital Cologne in Germany. "The treatment regimen of two cycles of escalated BEACOPP followed by AVBD chemotherapy and involved-field radiation has become the new standard of care in a follow-up study we are currently conducting, and this approach continues to improve tumor control rates in these patients."

Dr. Engert will present this study in an oral presentation on Monday, December 6, at 4:30 p.m. in Auditorium 320.

Results of a Pivotal Phase 2 Study of Brentuximab Vedotin (SGN-35) in Patients With Relapsed or Refractory Hodgkin Lymphoma [Abstract 283]

While 70-80 percent of all newly diagnosed patients with adult Hodgkin lymphoma are typically cured w
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Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

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