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New standards of care and novel treatment options for several forms of lymphoma unveiled
Date:12/6/2010

30 p.m. in Auditorium 320.

Dose-Escalation With BEACOPP Escalated Is Superior to ABVD in the Combined-Modality Treatment of Early Unfavorable Hodgkin Lymphoma: Final Analysis of the German Hodgkin Study Group (GHSG) HD14 Trial [Abstract 765]

Hodgkin lymphoma, a form of lymphoma characterized by the presence of Reed-Sternberg cells (a type of B cell), is estimated to represent 11.5 percent of all types of lymphoma diagnosed this year, including approximately 8,500 new cases in the United States alone.1,2 This type of cancer is also one of the most curable. Previous research of the HD8 trial by the German Hodgkin Study Group demonstrated that the standard treatment for early, unfavorable Hodgkin lymphoma is combination chemotherapy along with involved field radiation therapy (IF-RT) four cycles of ABVD chemotherapy (adriamycin, bleomycin, vinblastine, and dacarbazine) followed by IF-RT, a treatment in which radiation is delivered only to areas of the body affected by the lymphoma. Results from this study have shown that overall survival and freedom from treatment failure (time from random assignment to the occurrence of a Hodgkin lymphoma-specific event) at five years in patients treated with this particular regimen reached 91 percent and 83 percent, respectively.

In order to further improve the overall survival and freedom from treatment failure results, researchers from the German Hodgkin Study Group initiated a new study (HD14 trial) to determine whether an escalated dose of the BEACOPP chemotherapy regimen (cyclophosphamide, doxorubicin, etopodise, procarbazine, prednisone, bleomycin, and vincristine) added to standard ABVB chemotherapy would improve freedom from treatment failure in patients with early, unfavorable Hodgkin lymphoma.

In this study, a total
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Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

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