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New standards of care and novel treatment options for several forms of lymphoma unveiled
Date:12/6/2010

vier Hermine and Martin Dreyling, in which patients younger than 65 years with previously untreated stage 2, 3, or 4 mantle cell lymphoma were randomized to one of two treatment arms. In the control arm of the study, patients received six courses of rituximab and CHOP chemotherapy followed by high-dose myeloablative radiochemotherapy and an autologous stem cell transplant, a procedure in which patients receive an infusion of their own stem cells. In the experimental arm of the study, patients received alternating courses of CHOP chemotherapy and DHAP chemotherapy three times plus rituximab followed by a high-dose ARA-C myeloablative chemotherapy regimen and an autologous stem cell transplant.

The primary endpoint of the study was time to treatment failure (TTF). Stable disease after induction therapy as well as progression or death from any causes were considered treatment failures. Randomization in the study was stopped as soon as a significant difference was observed between the two study arms.

After a median follow up of 27 months, TTF had not yet been reached in the ARA-C arm as compared with 49 months in the control arm. At three years, the survival rate was 79 percent in the control arm and 80 percent in the ARA-C arm. Overall survival was found to be similar in both treatment arms with median overall survival not yet reached.

"Results of this study confirm that there is a new standard of care for the treatment of younger patients with previously untreated mantle cell lymphoma," said lead study author Olivier Hermine, MD, PhD, Professor, Head of the Hematological Department, Necker Hospital in Paris. "High-dose ARA-C chemotherapy should be part of the induction therapy along with rituximab and CHOP chemotherapy prior to an autologous stem cell transplant in order to improve outcomes without an increase in toxicity in these patients."

Dr. Hermine will present this study in an oral presentation on Sunday, December 5, at 4:
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Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

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