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New standards of care and novel treatment options for several forms of lymphoma unveiled
Date:12/6/2010

loablative Radiochemotherapy and ASCT in Mantle Cell Lymphoma: Results of the MCL Younger Trial of the European Mantle Cell Lymphoma Network (MCL net) [Abstract 110]

While recent treatment advances have improved outcomes over the last several decades for patients with mantle cell lymphoma (a fast-growing form of B-cell non-Hodgkin lymphoma found in the lymph nodes, bone marrow, blood, spleen, and gastrointestinal system), it is still associated with an overall poor prognosis and a median survival of three to four years. A previous study conducted by the European Mantle Cell Lymphoma Network (MCL net) found that high-dose chemotherapy followed by an autologous stem cell transplant resulted in a significant increase in progression-free survival in patients with advanced stage mantle cell lymphoma. Additionally, other studies have found that the addition of rituximab to CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without high dose ARA-C (cytarabine) prior to an autologous stem cell transplant may significantly improve remission rates and progression-free survival. One specific study from the GELA (Groupe d'Etude des Lymphomes de I'Adulte) that evaluated a regimen of rituximab and CHOP chemotherapy followed by rituximab and DHAP chemotherapy (dexamethasone, cytarabine, and cisplatin) prior to an autologous stem cell transplant resulted in an overall response rate of 95 percent and a complete response rate of 61 percent, which translated into a median event-free survival rate of 83 months (6.9 years) and an overall survival rate of 75 percent at five years.

In order to confirm the hypothesis that a high-dose ARA-C (cytarabine)-based chemotherapy induction regimen prior to an autologous stem cell transplant provides superior outcomes, researchers from MCL Net initiated a randomized study, led by Professors Oli
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Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

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