Navigation Links
New sporadic prion protein disease identified by Case Western Reserve
Date:8/13/2010

and pathological features quite different from those of all known types of human prion diseases. Further, after being tested for prion proteins via the Western blot the gold standard of prion disease diagnosis the cases were negative. Dr. Gambetti then collaborated with Dr. Zou, associate director at the center, to solve the riddle of a disease that exhibited some features of a prion disease in histopathological examination but was negative using the standard Western blot test.

Dr. Zou's lab performed a full characterization of the disease and discovered that the VPSPr-associated abnormal prion protein formed a ladder-like electrophoretic profile on Western blot. "When I obtained the first Western blot result of these cases with a different antibody against prions, I was surprised that these cases consistently exhibited this particular profile; one that I had never seen in my more than 10 years of work on human prion diseases," Dr. Zou, assistant professor of pathology at Case Western Reserve School of Medicine, recalls. This ladder-like profile is quite distinctive and very different from the profile of common prion diseases. "Discovery of this unique type of prion provides solid evidence that this novel disease may possess a pathogenesis that is different from that of the major prion diseases currently known," Dr. Zou adds.

Despite extensive research, a relatively large group of neurodegenerative diseases associated with dementia remain undefined. Before being discovered and characterized, VPSPr was one of the undefined dementing diseases. The discovery of VPSPr is chipping away at that group. In the two years since its discovery, more than 30 cases have been reported.

"If, as the current evidence indicates, the VPSPr mechanism of affecting the brain is different from that of other sporadic prion diseases, such as sCJD, the discovery of VPSPr would also provide the first example that the prion protein may spontaneously damage the brai
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Veterans Affairs Researchers Induce a New Transmissible Prion Disease
2. Prion Disease in Mice May Help Advance Alzheimers Research
3. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
4. Research highlights role of protein pair in obesity regulation
5. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
6. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
7. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
8. Protein Appears Key to Intestinal Balance
9. SIBLING proteins may predict oral cancer
10. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
11. Cells of aggressive leukemia hijack normal protein to grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... -- For patients infected with both HIV and hepatitis ... viruses, a small study suggests. Researchers said doctors ... people with the two diseases. "The findings ... important role in the management of individuals with [hepatitis ... Sherman, a professor of medicine at the University of ...
(Date:7/23/2014)... Cancer is a disease of the genome resulting from ... from our parents strong or weak predispositions to developing ... new mutations in our cells throughout our lifetime. Although ... a long time, researchers were not able to measure ... now. A team of geneticists from the University of ...
(Date:7/23/2014)... MI (PRWEB) July 23, 2014 Ticket ... Madrid vs. Manchester United tickets at Michigan Stadium . ... International Champions Cup will be held at the Big House ... of Michigan Wolverines, will be home to a game between ... from La Liga. The game will be held on August ...
(Date:7/23/2014)... NJ (PRWEB) July 23, 2014 CarePoint ... the first hospital in New Jersey to receive the ... advanced robotics platform in the da Vinci series. This ... a profound step forward in innovation. The intuitive da ... across a wide spectrum of minimally invasive and complex ...
(Date:7/23/2014)... This report defines and segments the "EHV ... Middle East & Africa, and Americas) - Global Trends ... analysis and forecasts of the global revenue. The global ... $10 billion in 2014 to nearly $14 billion by ... browse 49 Market Tables and 10 Figures Spread Through ...
Breaking Medicine News(10 mins):Health News:HIV Meds May Also Help Control Hepatitis C, Study Finds 2Health News:Genetics of cancer: Non-coding DNA can finally be decoded 2Health News:Real Madrid vs. Manchester United Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for ManU vs. Real Madrid Guinness International Champions Cup Tickets 2Health News:Real Madrid vs. Manchester United Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for ManU vs. Real Madrid Guinness International Champions Cup Tickets 3Health News:CarePoint Health is First in New Jersey to Receive Newest Surgical Robot Platform 2Health News:CarePoint Health is First in New Jersey to Receive Newest Surgical Robot Platform 3Health News:CarePoint Health is First in New Jersey to Receive Newest Surgical Robot Platform 4Health News:EHV Transmission Market $14 Billion by 2019 - Report by MarketsandMarkets 2Health News:EHV Transmission Market $14 Billion by 2019 - Report by MarketsandMarkets 3Health News:EHV Transmission Market $14 Billion by 2019 - Report by MarketsandMarkets 4
... Mass., Oct. 30 Repligen Corporation,(Nasdaq: RGEN ) ... Walter C. Herlihy, Ph.D., will host a conference call,and ... EST, to report,second quarter fiscal year 2009 financial results ... This call is being webcast by Thomson/CCBN and can ...
... Prices, According To New Data ... from Arlington Medical Resources, MALVERN, Penn., Oct. 30 ... the pharmaceutical and,diagnostic imaging industries, finds that echinocandins show growth in ... courses,in the January - June 2008 time period compared to 9 ...
... Visit Washington D.C. to Rally Residents to Eat Right, Move ... More and Milk Their ... by,the ups and downs of different fad diets -- which seem to ... success has been,slim. Two out of three Americans -- including 22% of ...
... Mid-Atlantic Region, ATLANTA, Oct. 30 AmeriCare ( ... the opening of its,latest franchises serving Howard, Montgomery, and ... states in the union, Maryland is in the,top 20 ... Marylanders is over the,age of 60. AmeriCare of Maryland ...
... MIAMI, Oct. 30 Physicians Healthcare,Management Group, Inc. (Phyhealth) ... in partnership with physicians,today announced that its board of ... to 5% of the Company,s outstanding Common Stock., ... at the market price.,The purchases will be made at ...
... MED ) announced today that it will release third quarter ... 30, 2008 on,Thursday, November 6, 2008. The Company will hold ... Thursday, November 6, at 11:00 a.m. ET., Interested parties ... or can listen via a live Internet web cast, which ...
Cached Medicine News:Health News:Repligen Announces Conference Call of Second Quarter Fiscal Year 2009 Results Thursday, November 6th, 10:00 a.m. EST 2Health News:Repligen Announces Conference Call of Second Quarter Fiscal Year 2009 Results Thursday, November 6th, 10:00 a.m. EST 3Health News:Echinocandins Show Growth Among All Antifungal Classes 2Health News:Echinocandins Show Growth Among All Antifungal Classes 3Health News:Message to Washington D.C. Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 2Health News:Message to Washington D.C. Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 3Health News:Caregiving Company AmeriCare Adds Franchise in Maryland 2Health News:Phyhealth Announces Stock Buyback Program 2Health News:Phyhealth Announces Stock Buyback Program 3Health News:Medifast, Inc. to Announce Third Quarter of Fiscal Year 2008 Financial Results on Thursday, November 6, 2008 2
(Date:7/23/2014)... LONDON , July 23, 2014  Lightlake ... developing addiction treatments based on its expertise in ... an investigational new drug application ("IND") with respect ... Lightlake also announced today that it has received ... Drug Abuse ("NIDA"), part of the National Institutes ...
(Date:7/23/2014)... , July 23, 2014  Silk Road ... the transcarotid treatment of intra- and extra-cranial cerebrovascular ... P. Wallace to the position of Chief ... lead the company,s Research and Development efforts across ... Prior to joining Silk Road ...
(Date:7/23/2014)... , July 23, 2014  ACON Equity Partners III, ... Investments, L.L.C. ("ACON") announced it has completed the purchase ... from Audax Group and Parthenon Capital Partners. IWP is ... billion Workers, Compensation, Automobile Personal Injury Protection and Personal ... . As part of this ...
Breaking Medicine Technology:Lightlake Therapeutics Inc. Files Investigational New Drug Application For Naloxone Nasal Spray For Reversing Opioid Overdose And Announces A Further Collaboration With The National Institute On Drug Abuse 2Lightlake Therapeutics Inc. Files Investigational New Drug Application For Naloxone Nasal Spray For Reversing Opioid Overdose And Announces A Further Collaboration With The National Institute On Drug Abuse 3Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 2Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 3ACON Investments Acquires Injured Workers Pharmacy 2ACON Investments Acquires Injured Workers Pharmacy 3
... Therapeutics, Inc. (Nasdaq: ECTE ), a company ... wireless, transdermal continuous glucose monitoring system and its Prelude® ... results for the year ended December 31, 2011.  Echo,s ... website at www.echotx.com . 2011 ...
...   Avanir Pharmaceuticals, Inc. (NASDAQ: AVNR ) ... of senior vice president and chief commercial officer. Mr. Palekar ... activities. "Rohan has an outstanding track record of ... president and CEO of Avanir. "I am delighted that we ...
Cached Medicine Technology:Echo Therapeutics, Inc. Announces 2011 Financial Results 2Echo Therapeutics, Inc. Announces 2011 Financial Results 3Echo Therapeutics, Inc. Announces 2011 Financial Results 4Echo Therapeutics, Inc. Announces 2011 Financial Results 5Avanir Pharmaceuticals Announces Appointment of Rohan Palekar as Chief Commercial Officer 2Avanir Pharmaceuticals Announces Appointment of Rohan Palekar as Chief Commercial Officer 3
... drive system which eliminates many of ... out. There are no motor brushes, ... drive belts - resulting in a ... carry weights up to 400 pounds. ...
... The Quinton Q-Stress Cardiac Stress ... baseline wander and muscle artifact ... second to provide the highest ... Leads can be displayed in ...
... ECT WS 2000 is designed to monitor, ... cardiovascular provocative tests, (stress-testing). The system can organize ... and provide them for a quick review and ... ,The recorded ECG is transmitted via a small ...
... compact BioStress 2000 is a software driven, ... testing system. The BioStress 2000 program is ... viewing, permanent ECG strorage and retrieval and ... printer. BioStress 2000 allows a wide range ...
Medicine Products: