Navigation Links
New software tool identifies genetic mutations that influence disease risk
Date:5/30/2014

HOUSTON-Researchers at The University of Texas MD Anderson Cancer Center and other institutions have applied a newly developed software tool to identify genetic mutations that contribute to a person's increased risk for developing common, complex diseases, such as cancer. The research is published in the May 2014 edition of the journal Nature Biotechnology.

The technology, known as pVAAST (pedigree Variant Annotation, Analysis and Search Tool), combines two different statistical methods used for identifying disease-causing gene mutations. This combination approach outperforms individual familial analysis methods by increasing power or speed in which mutations are identified, and reducing complications through study design and analysis.

"This method allows for faster, more efficient identification and validation of genetic variants that influence disease risk," Chad Huff, Ph.D., professor of Epidemiology at MD Anderson. "This will eventually enable clinical labs to design genetic tests that provide better predictions of a person's individual risk of developing cancer."

The pVAAST tool combines two commonly used disease-gene identification methods, linkage analysis and association tests. Linkage analysis tracks the inheritance of genetic mutations in families to identify possible causal mutations. Association tests compare unrelated individuals with a specific disease to healthy individuals in search of a common mutation in one group or the other.

"Linkage analysis and association tests were initially designed for sparse genetic markers available from earlier genotyping techniques," said lead author of the study, Hao Hu, Ph.D., a postdoctoral fellow of Epidemiology at MD Anderson. "pVAAST integrates these two methods and repurposes them for next-generation DNA sequencing data, which is the state-of-art technique for genetics research. It fills in a genuine gap between molecular techniques and computational tools in
'/>"/>

Contact: Katrina Burton
kburton@mdanderson.org
713-792-8034
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses
2. CU-built software uses big data to battle forgetting with personalized content review
3. PowerSteering from Upland Software Earns High Marks in Review by GetApp
4. 2013 W2 1099 Forms Software by W2Mate.Com Updates Print / E-File Capability; Simplifies W2 1099 Filing
5. Silvertip Software Re-Launches RoomTime Room-Scheduling App; Early Adopter Program Expires Soon, Limited Space Remains
6. Zane Benefits Publishes New Information on Defined Contribution Admin Software
7. Olea Medical® Receives FDA 510(k) Clearance for Olea Sphere v2.3 Medical Imaging Software
8. IntelliSoft Group to Release New Version of Contract Management Software
9. 2013 1099 Software by W2Mate.com Brings Pressure-Seal 1099s, SSN Masking and Blank Paper Printing to QuickBooks Users
10. Successful and Busy Veterinary Clinics: Become More Efficient with Updated and Advanced Time Clock Software
11. RealTaxTools.com Reveals 1099-S Software for Filing 2013 1099-S Real Estate Forms; Print and E-File Updated
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New software tool identifies genetic mutations that influence disease risk
(Date:10/22/2014)... October 22, 2014 Richard Carlson, Managing ... industry leader with over 25 years experience. Mr. ... in the areas related to EDI, B2B Commerce, RFID ... an Editorial Advisory Board member for Pharmaceutical Commerce Magazine ... Blue Fin Group is a management and technology consulting ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... undergoing in vitro fertilization (IVF) are only about half as ... assisted reproduction technique, new research indicates, and the racial disparity ... study, about 31 percent of white patients became pregnant after ... Analyzing more than 4,000 IVF cycles over two years to ...
(Date:10/22/2014)... Maureen Salamon HealthDay ... A crucial part of conventional in vitro fertilization (IVF) -- ... instead take place in a device inside the vagina, new ... contend that the device, called an INVOcell, might sharply cut ... also make the technology more accessible to those who don,t ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... who was diagnosed with Ebola while working for NBC News ... can leave the special isolation unit at Nebraska Medical Center in ... the hospital said Tuesday. A blood test confirmed by the ... 33, can head home to Providence, R.I., NBC News ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute is offering ... a damaged mitral valve as the heart continues to ... Abbott Vascular , is designed to treat degenerative ... which the heart’s mitral valve leaflets fail to close ... left ventricle into the left atrium. The heart must ...
Breaking Medicine News(10 mins):Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3
... for weight loss alone, other plans also work well, studies ... diet helps people shed as many pounds as a low-fat ... plan may be better at helping lower blood pressure, researchers ... of the Archives of Internal Medicine , found that ...
... could raise risk for heart disease later , MONDAY, Jan. ... pregnancy have blood pressure problems at birth that persisted through ... "What is of concern is that the problems are present ... a senior research scientist in the department of women and ...
... ... Men Say They Feel Inadequate , ... January 25, 2010 -- Struggling to get pregnant can be a serious blow to the self-esteem ... (71 percent) women said that infertility makes them feel flawed, while half of men (50 percent) ...
... Jan. 25 During a visit today to Avonworth ... Secretary of Education Gerald Zahorchak commended the school for ... all Pennsylvania children are overweight or obese, putting them ... like Avonworth are making the health of children a top priority ...
... higher rates of specific musculoskeletal injuries and medical conditions ... Harber in the Faculty of Physical Education and Recreation ... paper, depending on the sport, there can be a ... between male and female athletes. That,s because many training ...
... ... Flu: No Waiting in Long Lines , ... San Diego, Calif. (Vocus) January 25, 2009 -- U.S. HealthWorks Medical Group, a ... they are offering H1N1 vaccine shots for $15 per shot for both walk-ins – no ...
Cached Medicine News:Health News:For Lower Blood Pressure, Low-Carb Diet May Be Best 2Health News:For Lower Blood Pressure, Low-Carb Diet May Be Best 3Health News:Newborns of Smokers Have Abnormal Blood Pressure 2Health News:Newborns of Smokers Have Abnormal Blood Pressure 3Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 2Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 3Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 4Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 5Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 6Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 7Health News:New Survey Finds Infertility Delivers a Serious Blow to Self-Esteem 8Health News:State Health, Education Leaders Hail Avonworth Middle School in Allegheny County for Boosting Physical Activity Among Students 2Health News:Female athletes injured more than male athletes 2Health News:U.S. HealthWorks in San Diego Region Offering $15 H1N1 Vaccinations for both Walk-Ins and On-Site 2
(Date:10/20/2014)... , 20 de octubre de 2014 /PRNewswire/ ... el campo de la pulmonología intervencional, anunció hoy ... RENEW, casi 3 meses antes de lo programado. El ... exención de dispositivo de investigación (IDE) aprobada por ... el sistema de espiral de reducción de volumen ...
(Date:10/20/2014)...  ResMed (NYSE: RMD ) today ... program, a comprehensive suite of software and service ... health care providers. ResMed Data ... information. It integrates valuable sleep and respiratory treatment ... platforms with customers, in-house or third-party electronic health ...
(Date:10/20/2014)...  AnaptysBio, Inc., a leader in the discovery ... appointment of Marco Londei , M.D. as ... preclinical and clinical development of AnaptysBio,s proprietary antibody ... welcome Dr. Londei to AnaptysBio,s executive leadership team," ... Executive Officer of AnaptysBio. "Dr. Londei,s extensive expertise ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3ResMed Launches ResMed Data Exchange 2AnaptysBio Appoints Dr. Marco Londei to Newly Created Chief Development Officer Position Clinical Immunologist to Lead AnaptysBio's Pipeline Advancement 2
... 2011  Seventeen of the 19 medical-surgical suppliers and healthcare ... 25 for 2011 work with GHX to automate and ... them achieve high-quality patient care at optimal economic cost. ... and providers recognized by Gartner in the Top 25 ...
... 2011 ULURU Inc. (NYSE AMEX: ... of the previously announced European license for Altrazeal®, with a ... Zealand. Extending the European territory to include ... is a common registration process and the marketing strategy and ...
Cached Medicine Technology:GHX Salutes 17 Healthcare Organizations That Use Its Technology for Inclusion on a Leading Analyst Firm's 2011 Healthcare Supply Chain Top 25 List 2ULURU Inc. Extends the European Altrazeal® License to Include Australia and New Zealand 2ULURU Inc. Extends the European Altrazeal® License to Include Australia and New Zealand 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: