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New screening method can detect a range of clinical conditions from a single dried blood spot
Date:11/16/2011

has already been successfully used to provide rapid diagnosis of a comprehensive range of inherited metabolic diseases in acutely ill children admitted to intensive care with life-threatening symptoms.
  • Pre-symptomatic screening for chronic health problems will introduce personalised clinical diagnostics and cost-effective early detection and monitoring of diabetes and kidney and heart disease.

    Dried urine spots can also be used for the very early detection of kidney disease, particularly in patients with a high risk of developing renal complications, for example patients with type 1 or type 2 diabetes.

    The test works by converting proteins to peptides and then using a mass spectrometer to select and accurately measure diagnostic metabolites and/or peptides. Liquid blood and urine samples can also be screened using the method.

    Compared with conventional clinical laboratory diagnostics the major advantages of the new method are that the measurements for proteins and metabolites can be done simultaneously with both high accuracy and sensitivity. Dried blood spots and/or dried urine spots offer significant cost savings in the logistics of sample collection, transport to the laboratory, sample processing, and storage.

    Neil Dalton, Professor of Paediatric Biochemistry at King's, and co-founder of SpotOn, said: "The lessons we have learned from universal pre-symptomatic screening of newborn babies using dried blood spots can now be cost-effectively applied to provide a personalised medicine approach to the early diagnosis and clinical monitoring of major chronic health problems like diabetes and kidney and heart disease."


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  • Contact: Katherine Barnes
    katherine.barnes@kcl.ac.uk
    44-207-848-3076
    King's College London
    Source:Eurekalert

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