Navigation Links
New screening method can detect a range of clinical conditions from a single dried blood spot

Scientists have developed a rapid method that can be used to simultaneously screen patients for a range of genetic and acquired clinical conditions from a single dried blood spot.

The test uses a highly sensitive and specific technique, known as mass spectrometry, to simultaneously analyse proteins, enzymes and metabolites in the blood, without the need for the large liquid blood samples currently used. Collection of dried blood spots is less invasive for patients and the costs and biohazards associated with sample transport, processing and storage are minimised.

Researchers at King's College London, together with clinicians from Guy's and St Thomas' NHS Foundation Trust, as part of King's Health Partners Academic Health Sciences Centre, have built on their innovative approaches to dried blood spot screening for inherited metabolic disease and sickle cell disease in newborn babies. This approach can now be used in the early detection and clinical monitoring of chronic health problems, including kidney and heart disease and diabetes.

King's has today officially launched a spin-out company, SpotOn Clinical Diagnostics Ltd, to provide both analytical services and technical support for other clinical laboratories, many of which already have appropriate mass spectrometry instrumentation, to offer this new method.

Requiring only a drop of blood from a simple finger-prick, or heel-prick in newborns, this new blood spot analysis method has many potential applications:

  • The method is faster, more specific, and cheaper than the methods currently used to screen all 750,000 babies born each year in the UK for sickle cell disease and other clinically significant haemoglobinopathies (abnormalities in haemoglobin within the blood). The current methods for ante-natal screening for sickle cell disease and thalassaemia require fresh liquid blood samples, which are more expensive to process, store and transport.
  • The method has already been successfully used to provide rapid diagnosis of a comprehensive range of inherited metabolic diseases in acutely ill children admitted to intensive care with life-threatening symptoms.
  • Pre-symptomatic screening for chronic health problems will introduce personalised clinical diagnostics and cost-effective early detection and monitoring of diabetes and kidney and heart disease.

Dried urine spots can also be used for the very early detection of kidney disease, particularly in patients with a high risk of developing renal complications, for example patients with type 1 or type 2 diabetes.

The test works by converting proteins to peptides and then using a mass spectrometer to select and accurately measure diagnostic metabolites and/or peptides. Liquid blood and urine samples can also be screened using the method.

Compared with conventional clinical laboratory diagnostics the major advantages of the new method are that the measurements for proteins and metabolites can be done simultaneously with both high accuracy and sensitivity. Dried blood spots and/or dried urine spots offer significant cost savings in the logistics of sample collection, transport to the laboratory, sample processing, and storage.

Neil Dalton, Professor of Paediatric Biochemistry at King's, and co-founder of SpotOn, said: "The lessons we have learned from universal pre-symptomatic screening of newborn babies using dried blood spots can now be cost-effectively applied to provide a personalised medicine approach to the early diagnosis and clinical monitoring of major chronic health problems like diabetes and kidney and heart disease."


Contact: Katherine Barnes
King's College London

Related medicine news :

1. Population-specific community-based cancer screening may discourage smoking
2. Few doctors follow sudden cardiac death screening guidelines for athletes
3. Fecal occult blood testing effective in colonoscopy screenings
4. Birth cohort screening for hepatitis C is cost effective, could save thousands of lives each year
5. Change in Hepatitis Screening May Save Lives, Money
6. Research supports broader screening for sudden cardiac death
7. New research on improved treatment options and screening strategies for Hepatitis C
8. X-Ray Screening Doesnt Prevent Lung Cancer Deaths: Study
9. CT scans for lung cancer screening may be beneficial in detecting COPD
10. Probability model estimates proportion of women who survive breast cancer detected through screening
11. Cheaper and easier isnt necessarily better in new colon cancer screening procedures
Post Your Comments:
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... awareness about the dangers associated with chronic pain and the benefits of holistic treatments, ... for individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
Breaking Medicine Technology: