Navigation Links
New screening halves the number of children born with Down syndrome
Date:11/27/2008

A new national screening strategy in Denmark has halved the number of infants born with Down's syndrome and increased the number of infants diagnosed before birth by 30%, according to a study published on bmj.com today.

Many countries, including England, Australia and New Zealand, are trying to introduce national screening strategies for Down's syndrome, but are facing a variety of problems because of a lack of consensus about the screening policy and logistical challenges.

In 2004, the Danish National Board of Health issued new guidelines for prenatal screening and diagnosis. These included the offer of a combined test for Down's syndrome (based on combination of maternal age, plus serum and nuchal screening) in the first trimester. This test gave women a risk assessment for Down's syndrome at an early stage in the pregnancy. Women whose risk was higher than a defined cut off were referred for invasive diagnostic tests (chorionic villus sampling or amniocentesis).

In the previous guidelines screening for Down's syndrome was based on maternal age and a diagnostic test was mainly offered to women above 35 years.

Professor Ann Tabor and colleagues from Denmark, evaluated the impact of the new national screening strategy on the number of infants born with Down's syndrome and the number of referrals for invasive procedures. They analysed data from the 19 Danish departments of gynaecology and obstetrics and the national cytogenetic registry, for an average of 65,000 births each year, between 2000 and 2007.

Uptake was good, by June 2006 all 15 Danish counties followed the guidelines from 2004 and offered the new screening strategy. In 2006 approximately 84% of pregnant women had a risk assessment for Down's syndrome.

The researchers found that the new strategy was associated with improved earlier detection of Down's syndrome, low false positive rates, and more than a 50% decrease in the number of invasive tests carried out each year.

They report that the number of infants born with Down's syndrome decreased from 55󈞭 per year during 2000𔃂, to 31 in 2005 and 32 in 2006. The total number of invasive tests fell sharply from 7524 in 2000 to 3510 in 2006.

The detection rate in the screened population was 86% in 2005 and 93% in 2006. With 3.9% (17) of women receiving a false positive result in 2005 and 3.3% (7) in 2006.

The authors point out that the value of this new screening strategy is that all women can be assessed early in pregnancy (in the first trimester). The national guidelines emphasise that risk assessment should only be done if women choose the test on the basis of informed choice, therefore despite the programme being available to all pregnant in women in Denmark, some will still choose not to be screened.

The authors conclude by emphasising Denmark's success at building a strong national organisation for fetal medicine and a national quality database that allows follow-up of all screened women at a national level and quality control of the new national screening programme.


'/>"/>

Contact: Rachael Davies
rdavies@bma.org.uk
44-020-738-36529
BMJ-British Medical Journal
Source:Eurekalert

Related medicine news :

1. When Is Screening for Renal Artery Stenosis Medically Necessary?
2. Mexican Department of Public Health to Launch Screening for Papillomavirus, Cause of Cervical Cancer
3. Fear, misconceptions about screenings keep many African-Americans from getting mammograms
4. Messages of hope work better in motivating black patients to seek early screening for cancer
5. New technology could revolutionize breast cancer screening
6. Study Questions Screening Heart Attack Patients for Depression
7. Transitions Optical to Provide Free Vision Screenings at the American Diabetes Associations Feria de Salud por tu Familia(TM)
8. Columbus Medicare Diabetes Screening Project Cited as Model for State by Lt. Governor Casey Cagle
9. Minority patients discouraged from cancer screening by negative messages
10. Research indicates need for effective HPV vaccine for women and men and a simple HPV screening test
11. Free Flu Shots, Health, Dental Screenings and Services Available to New Kensington Area Adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... Come to ... Hotel, 4200 Jim Walter Blvd, for an educational and exciting 2-day program. , ... our staff hearing this before they approach patients” about the course entitled Ain't Misbehavin': ...
(Date:4/24/2017)... ... April 24, 2017 , ... “Reflections of God’s Work”: an enlightening ... God’s Work” is the creation of published author, Jerri Broglin, a survivor of great ... “I believe this a great eye-opener for those searching for answers, as we are ...
(Date:4/24/2017)... ... April 24, 2017 , ... Life of Purpose Treatment is proud to present ... be held at 7:30 pm on May 10th at the University Auditorium. , This ... Hazel, will support the UF Collegiate Recovery Community (UFCRC). The concert will kick off ...
(Date:4/23/2017)... ... April 23, 2017 , ... "An event Horizon is a place ... rendered in my Art and Music. These are created as Metaphysical Transformations where music, ... of mystery culminate to the ultimate singularity.", -- Karen Salicath Jamali , Karen will ...
(Date:4/22/2017)... ... April 22, 2017 , ... ... U.S. consumers can save an average of 70% when buying medication online from ... 97%) are available when purchasing from other countries. The report (chart below) compares ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... DUBLIN , April 20, 2017 ... "Latin America Pharmaceutical Contract Manufacturing Services Market Analysis By Service ... And Segment Forecasts, 2014 - 2025" report to their ... The Latin ... USD 21.0 billion by 2025 Low drug registration ...
(Date:4/19/2017)... , April 19, 2017 The Mobile X-Ray product ... a healthy CAGR during the forecast period Mobile ... the global digital mobile X-Ray devices market, which is estimated ... 2017, expanding at a CAGR of 7% over the forecast ... opportunity of more than US$ 100 Mn in 2017 over ...
(Date:4/19/2017)... 19, 2017 Global Prostate Cancer Therapeutics ... the prostate cancer therapeutics market analyzes the current ... prevalence of prostate cancer, launch of promising emerging ... of new drugs & therapeutic biological products, and ... to lesser side effects are some of the ...
Breaking Medicine Technology: