Navigation Links
New screening approach identifies small proteins unique to melanoma cells, Moffitt researcher says
Date:6/25/2013

Jamie K. Teer, Ph.D., assistant member of the Cancer Biology and Evolution Program at Moffitt Cancer Center, and colleagues have developed a new streamlined method to rapidly identify the genetic changes in small protein fragments unique to melanoma cancer cells. These fragments can be used as targets for tumor-infiltrating lymphocytes that have been shown to reduce cancerous lesions.

The new approach is outlined in an article published online by Nature Medicine in May.

A previous phase 2 clinical trial showed substantial regression of metastatic lesions in up to 70 percent of melanoma patients who were treated with self-donated tumor-infiltrating lymphocytes.

"The trial, which involved the adaptive transfer of a patient's own immune cells, showed a complete tumor regression lasting at least five years in nearly 40 percent of the patients," Teer said. "To better understand how this works, researchers needed to identify tumor-infiltrating lymphocytes. We developed a new method to help do that more quickly."

Tumor-infiltrating lymphocytes are white blood cells that have left the bloodstream and migrated into a tumor. When numerous tumor-infiltrating lymphocytes are present, it suggests an immune response against the tumor. Research into quantifying the tumor-infiltrating lymphocytes and relating those numbers to tumor characteristics and outcomes has been carried out across many types of cancer.

According to Teer, a better understanding of how tumor-infiltrating lymphocytes induce cancer cell regression should increase the effectiveness of patient-donated cell therapy and also potentially reveal novel mechanisms of tumor growth. The technique uses next-generation DNA sequencing technologies to identify the changes that lead to the unique protein fragments.

"Our new technique allowed us to more quickly and easily identify mutated gene antigens recognized by T-cells in the immune system," explained Teer. "Work such as this was previously done by generating and laboriously screening DNA libraries from tumors. The same screening technique may be applicable for identifying mutated antigens in a variety of tumor types."


'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Depression screening in AF Clinics recommended by study
2. Kansas City Dermatologists at The Skin and Vein Center Offer Complimentary Vein Screening on July 9
3. Screening fails to affect breast cancer mortality statistics
4. Screening at-risk adolescents for celiac disease proves cost-effective
5. Amco Agency announce an Immediate Sale or Licensing Opportunity: Fluorescent Lifetime Test / Drug Screening Equipment and Consumables
6. Online Dementia and Alzheimer’s Screening Test Now Available to the Public on CognitiveTest.com
7. Digital chest tomosynthesis possible lung cancer screening tool
8. Colon cancer screening: Immunological tests are superior
9. New screening approach uncovers potential alternative drug therapies for neuroblastoma
10. Genetic screening could reveal hidden high risk for coronary heart disease
11. Pulse Oximetry Screening for Newborns a Reality in North Carolina
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... MD (PRWEB) , ... January 18, 2017 , ... The ... consultations to families and business owners in central Maryland and the DC region, is ... Heart disease kills 787,000 people nationally every year, making it the #1 killer in ...
(Date:1/18/2017)... , ... January 18, 2017 , ... Dr. Farhan Qureshi ... cosmetic and implants dentistry. His modern dental practice has two convenient office locations in ... 2017 Top Rated Dentist for the Alexandria area. This award confirms the ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... time support an aid project with the donation of cochlear implants. In February ... of hearing and thus a fair chance of leading an independent life. This ...
(Date:1/18/2017)... ... ... Floundering on New Year’s resolutions? Need an excuse to get back on track? ... Apple Association agrees and recommends starting each day with apples, a habit proven ... , The U.S. Apple Association – which represents apple growers and producers nationwide – ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... Gym Source, ... of a new showroom at South Dixie Hwy in Miami, FL. , “We are ... Gym Source. “The new innovative in-store concept is designed to give clients a seamless ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... 17, 2017 Research and Markets has ... 2017 - 2024" report to their offering. ... This new report revisits the ... that was issued in May of 2015. Self-healing is an area ... previous analysis we projected a market potential of $2.7 billion ($US) ...
(Date:1/17/2017)... -- Paragon Bioservices received a multiple-award, indefinite-delivery, indefinite-quantity ... a variety of National Institute of Allergy ... activities. The IDIQ mechanism will allow Paragon to ... awards up to $159 million. Paragon ... development of biopharmaceuticals, is one of four awardees ...
(Date:1/17/2017)... Management to Discuss Acquisition of ... KIT-302 Development On Track For An NDA ... Q1 2017   ... Holdings Ltd. (NASDAQ: KTOV ; TASE: KTOV), an innovative biopharmaceutical company, ... rd at 8:30am Eastern Time to discuss the recent acquisition of a ...
Breaking Medicine Technology: