Navigation Links
New screening approach identifies small proteins unique to melanoma cells, Moffitt researcher says
Date:6/25/2013

Jamie K. Teer, Ph.D., assistant member of the Cancer Biology and Evolution Program at Moffitt Cancer Center, and colleagues have developed a new streamlined method to rapidly identify the genetic changes in small protein fragments unique to melanoma cancer cells. These fragments can be used as targets for tumor-infiltrating lymphocytes that have been shown to reduce cancerous lesions.

The new approach is outlined in an article published online by Nature Medicine in May.

A previous phase 2 clinical trial showed substantial regression of metastatic lesions in up to 70 percent of melanoma patients who were treated with self-donated tumor-infiltrating lymphocytes.

"The trial, which involved the adaptive transfer of a patient's own immune cells, showed a complete tumor regression lasting at least five years in nearly 40 percent of the patients," Teer said. "To better understand how this works, researchers needed to identify tumor-infiltrating lymphocytes. We developed a new method to help do that more quickly."

Tumor-infiltrating lymphocytes are white blood cells that have left the bloodstream and migrated into a tumor. When numerous tumor-infiltrating lymphocytes are present, it suggests an immune response against the tumor. Research into quantifying the tumor-infiltrating lymphocytes and relating those numbers to tumor characteristics and outcomes has been carried out across many types of cancer.

According to Teer, a better understanding of how tumor-infiltrating lymphocytes induce cancer cell regression should increase the effectiveness of patient-donated cell therapy and also potentially reveal novel mechanisms of tumor growth. The technique uses next-generation DNA sequencing technologies to identify the changes that lead to the unique protein fragments.

"Our new technique allowed us to more quickly and easily identify mutated gene antigens recognized by T-cells in the immune system," explained Teer. "Work such as this was previously done by generating and laboriously screening DNA libraries from tumors. The same screening technique may be applicable for identifying mutated antigens in a variety of tumor types."


'/>"/>

Contact: Kim Polacek
kim.polacek@moffitt.org
813-745-7408
H. Lee Moffitt Cancer Center & Research Institute
Source:Eurekalert

Related medicine news :

1. Depression screening in AF Clinics recommended by study
2. Kansas City Dermatologists at The Skin and Vein Center Offer Complimentary Vein Screening on July 9
3. Screening fails to affect breast cancer mortality statistics
4. Screening at-risk adolescents for celiac disease proves cost-effective
5. Amco Agency announce an Immediate Sale or Licensing Opportunity: Fluorescent Lifetime Test / Drug Screening Equipment and Consumables
6. Online Dementia and Alzheimer’s Screening Test Now Available to the Public on CognitiveTest.com
7. Digital chest tomosynthesis possible lung cancer screening tool
8. Colon cancer screening: Immunological tests are superior
9. New screening approach uncovers potential alternative drug therapies for neuroblastoma
10. Genetic screening could reveal hidden high risk for coronary heart disease
11. Pulse Oximetry Screening for Newborns a Reality in North Carolina
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... ... February 26, 2017 , ... ODH, Inc.™ announced today it ... at the Sheraton Pentagon City Hotel in Arlington, VA. ODH’s director of medical strategy, ... health analytics to improve Medicaid population health management. , ODH will also have an ...
(Date:2/26/2017)... ... February 26, 2017 , ... Occupational pesticide exposure ... a specific LRRK2 mutation, according to a study released today at the 1st ... of a link between pesticides and incidence of sporadic PD through occupational exposure. ...
(Date:2/24/2017)... ... February 24, 2017 , ... HealthPostures, expert standing desk ... and advantages built into the home office sit stand solution are bold colors, ... to gain the benefits embedded in the TaskMate Go are available 24/7 through ...
(Date:2/24/2017)... ... February 24, 2017 , ... Only two months after the ... Market (ILTM) show in Cannes (France), XO Private has initiated a second print-run of ... book measures almost a metre across when open, weighs in at more than six ...
(Date:2/24/2017)... ... February 24, 2017 , ... An in-depth computational analysis of ... of Pittsburgh points to eight genes that may explain why susceptibility to one of ... results of a study published today in the journal npj Schizophrenia. , “There ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... Feb. 27, 2017  A landmark study ... , MBBS, PhD, FRACS, of  Sydney Heart and ... Sydney will be published in the February 28, ... American College of Cardiology . According to the study, which ... bypass surgery technique (anOPCABG) reduced postoperative stroke ...
(Date:2/27/2017)...  International Biophysics Corporation, a global medical device manufacturer based ... 34% revenue growth in 2016 when compared to the previous ... growth was fueled by its AffloVest® sales in ... of its global sales of surgical product lines. ... enter our 25 th year in delivering high-quality, innovative ...
(Date:2/27/2017)... Md. , Feb. 27, 2017  RegeneRx ... a clinical-stage drug development company focused on tissue ... licensee for RGN-137, GtreeBNT Co., Ltd., received a ... Phase 3 clinical trial design for RGN-137 to ... wound healing gel that incorporates Thymosin beta 4 ...
Breaking Medicine Technology: